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Pharmaceutical composition for treating diabetic retinopathy caused by deficiency of both vital energy and yin and preparation method of pharmaceutical composition

A technology for retinopathy and diabetes, which is applied in the field of pharmaceutical preparations, can solve the problems of treating the symptoms but not the root cause, unfavorable treatment, and dependence, etc., and achieve the effect of definite curative effect, no toxic side effects, low price, and fast onset of effect

Inactive Publication Date: 2015-10-07
吴强
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0016] However, the above-mentioned western medicines treat the symptoms but not the root cause, which is not conducive to treatment, and is commonly used with dependence and side effects

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0071] When the dosage form of the pharmaceutical composition is a granule, its preparation method comprises the following steps:

[0072] The first step is to mix the raw materials of the pharmaceutical composition according to the stated ratio, add ethanol with an alcohol concentration of 85% to 95% that is 4 to 8 times that of the mixture, heat to boiling and reflux for 3 to 5 hours, and filter. Use the percolation method to percolate slowly at a rate of 1-2ml per minute, collect the percolation liquid, and then concentrate under reduced pressure at a vacuum of 0.06-0.09Mpa to a paste with a relative density of 1.04-1.10 at 50-60°C. Spray drying, the air inlet temperature of the spray dryer is 160-175°C, the outlet air temperature is 80-85°C, and then crushed into powder to make dry paste powder;

[0073] In the second step, 0.2-0.4 times of sucrose powder and 0.1-0.2 times of dextrin are added to the obtained dry paste powder to form granules, and dried at 40-50° C. to obt...

Embodiment 1

[0082] Example 1 Granules

[0083] The preparation process of the granule of the present invention is: get Tremella 150g, Smilax smilax 300g, Panlong ginseng 200g, Amaranth 320g, Tibetan green fruit 180g, Caragana root 330g, Dendrobium 140g, Tortoise shell 300g, Tribulus terrestris 220g, Black ginseng 30g, 130g Hovenia dulcis, 350g Daxueteng, 200g Paicaoxiang, 160g fruit leaves, 170g Shixiantao, 150g persimmon cream, 220g Ligustrum lucidum, 300g Bai Wei, 150g angelica, 320g tartar chrysanthemum, 200g ginseng, 130g Ulva , Ophiopogon japonicus 180g, Shudai fern 320g, Schisandra chinensis 150g, Gingeria chinensis 240g, Habitat 140g and Predict 300g;

[0084] The first step is to mix the raw materials of the pharmaceutical composition according to the stated ratio, add ethanol with an alcohol concentration of 90% that is 7 times that of the mixture, heat to boiling and reflux for 4 hours, filter, and use the percolation method at a rate of 90% per minute. Slowly percolate at a sp...

Embodiment 2

[0086] Example 2 Capsules

[0087] The preparation process of the capsule of the present invention is: get Tremella 160g, Smilax smilax 220g, Panlong ginseng 150g, Amaranth 340g, Tibetan green fruit 200g, Caragana root 330g, Dendrobium 200g, Tortoise shell 300g, Tribulus terrestris 320g, Black ginseng 30g, 140g of Hovenia dulcis, 250g of Daxueteng, 160g of Paicaoxiang, 200g of upper leaves, 250g of Shixiantao, 120g of persimmon cream, 220g of Ligustrum lucidum, 300g of Bai Wei, 250g of angelica, 330g of tartar chrysanthemum, 160g of ginseng, 150g of Ulva , Ophiopogon japonicus 210g, Shudai fern 300g, Schisandra chinensis 200g, Gingeria chinensis 300g, Habitat 180g, and Zhizhizi 330g;

[0088] The first step is to mix the raw materials of the pharmaceutical composition in proportion, add ethanol with an alcohol concentration of 95% that is 3 times the mass of the mixture, heat and reflux for 2 hours, extract, and filter to obtain the first extract; Add 90% ethanol with an alco...

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Abstract

The invention discloses a pharmaceutical composition for treating diabetic retinopathy caused by deficiency of both vital energy and yin and a preparation method of the pharmaceutical composition. The pharmaceutical composition comprises the following medicinal materials: tremella, smilax starts, spiranthes sinensis ames, alligator weed, myrobalan, intermediate peashrub root, dendrobe, carapax eretmochelyos, atriplex centralasiatica, dunn antiotrema root, hovenia dulcis thumb, sargentgloryvine stem, hairystalk loosestrife herb, denseflower bulbophyllum herb, pholidota cantonensis, persimmon frost, glossy privet fruit, blackend swallowwort root, angelica sinensis, west szechwan pyrethrum flower, ginseng, ulva, radix ophiopogonis, vittaria flexuosa, schisandra chinensis, semen thlaspi, dried radix rehmanniae and akebia quinata. The pharmaceutical composition has the efficacies of tonifying qi, nourishing yin, promoting blood circulation, improving eyesight, clearing heat, moistening dryness, helping production of saliva and slaking thirst, is mainly used for treating diabetic retinopathy caused by deficiency of both vital energy and yin; scientific combination is carried out by employing the traditional Chinese medicines with different medicine properties; microcirculation of ocular tissues, nerves and blood vessels can be prompted to be normal; the metabolic cycle of cells is delayed; eye diseases leading to blindness is prevented; and the pharmaceutical composition has the advantages of fast acting, high effective rate, accurate curative effect, short treatment course, no a toxic or side effect and low price.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparations, in particular to a pharmaceutical composition for treating diabetic retinopathy of deficiency of both qi and yin and a preparation method thereof. Background technique [0002] Diabetic retinopathy (DR) is the most important manifestation of diabetic microangiopathy, a fundus lesion with specific changes, and one of the serious complications of diabetes. Clinically, according to the presence or absence of retinal neovascularization as a sign, diabetic retinopathy without retinal neovascularization is called non-proliferative diabetic retinopathy (NPDR) or called simple or background type, while those with retinal neovascularization are called non-proliferative diabetic retinopathy (NPDR). Diabetic retinopathy is called proliferative diabetic retinopathy (PDR). [0003] The etiology of diabetic retinopathy: Diabetic patients mainly have abnormal insulin hormone and cell meta...

Claims

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Application Information

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IPC IPC(8): A61K36/8984A61K36/90A61P3/10A61P9/10A61P27/02A61K35/586
Inventor 吴强
Owner 吴强
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