Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Nitric oxide concentration elevating agent

A nitric oxide and concentration technology, which is applied in metabolic diseases, extracellular fluid diseases, peptide/protein components, etc., can solve the problems of unclear NO concentration and increase, so as to improve shoulder stiffness, increase muscle metabolism, and improve fear of cold disease effect

Pending Publication Date: 2015-09-30
KYOWA HAKKO BIO CO LTD
View PDF8 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] However, these prior reports are limited by specific experimental conditions such as exogenous addition of NO donors, evaluation of isolated blood vessels, and depletion of intrinsic glutathione concentrations by inhibition of glutathione synthesis. So far, it is not at all clear that the concentration of NO in vivo is increased by glutathione alone in individual animals

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Nitric oxide concentration elevating agent
  • Nitric oxide concentration elevating agent

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0086] Manufacture of tablets containing glutathione

[0087] 120kg of reduced glutathione, 19kg of cyclic oligosaccharides, 57kg of cellulose and 1kg of amylopectin were granulated with a fluidized bed granulation dryer. The obtained granules and 3 kg of calcium stearate were mixed with a cone mixer, and then compression-molded with a rotary compression molding machine to manufacture tablets.

Embodiment 2

[0089] Manufacture of enteric-coated tablets containing glutathione

[0090] Enteric-coated tablets were produced by coating the surface of the tablets produced in Example 1 with a shellac solution.

Embodiment 3

[0092] Manufacture of enteric-coated capsules containing glutathione

[0093] 120kg of reduced glutathione, 19kg of cyclic oligosaccharides, 57kg of cellulose, 3kg of calcium stearate and 1kg of pullulan were mixed with a cone mixer. The mixture obtained by mixing and stirring 20 kg of the obtained mixture and 0.2 kg of silicon dioxide was put into a capsule filling machine, and filled into hard capsules to obtain hard capsules. Enteric-coated capsules were produced by coating the surface of the obtained hard capsules with a zein solution.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

A nitric oxide (NO) concentration elevating agent containing glutathione or a salt thereof as an active ingredient, an NO concentration elevating agent containing glutathione or a salt thereof as an active ingredient for preventing or alleviating symptoms related to decreased vascular endothelial function or promoting vasodilation or blood flow by elevating NO concentration, and a method for elevating NO concentration by taking in glutathione or a salt thereof.

Description

technical field [0001] The present invention relates to an agent for increasing NO concentration, which contains glutathione or a salt thereof as an active ingredient, and which can be expected to prevent or improve the reduction of vascular endothelial function through a higher action of increasing nitric oxide (NO) in a living body Symptoms or effects of dilating blood vessels and promoting blood flow. Background technique [0002] NO is a gaseous substance that has various physiological functions as a signal. NO produced from vascular endothelial cells is called endothelium-derived relaxing factor (EDRF: Endothelium-derived relaxing factor), which has a vasodilation effect, an oxidized LDL inhibitory effect, a platelet aggregation inhibitory effect, an anti-smooth muscle cell proliferation effect, and an antioxidant effect various physiological activities for maintaining normal vascular function (Non-Patent Document 1). [0003] Arteriosclerosis is a state in which the ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K38/00A61P3/04A61P3/06A61P9/00A61P9/10A61P13/12A61P15/10A61P17/00A61P25/28A61P27/02A61P43/00
CPCA61K38/063A61K31/198A61P11/00A61P13/12A61P15/10A61P17/00A61P21/02A61P25/28A61P27/02A61P3/00A61P3/02A61P3/04A61P3/06A61P43/00A61P7/10A61P9/00A61P9/10A61P9/12
Inventor 森田匡彦神村彩子
Owner KYOWA HAKKO BIO CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com