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Application of litchi peel polyphenols in the preparation of drugs or health products for lowering liver cholesterol

A lychee skin and cholesterol technology, which can be used in drug combinations, medical preparations containing active ingredients, food science, etc., and can solve problems such as failure to be effectively developed and utilized

Active Publication Date: 2018-05-04
GUANGXI INST OF BOTANY THE CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

During the deep processing of lychee, about 40% of the fresh fruit’s peel and stone waste are produced, and a large amount of lychee peel has not been effectively developed and utilized as a bulk agricultural product waste.

Method used

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  • Application of litchi peel polyphenols in the preparation of drugs or health products for lowering liver cholesterol
  • Application of litchi peel polyphenols in the preparation of drugs or health products for lowering liver cholesterol
  • Application of litchi peel polyphenols in the preparation of drugs or health products for lowering liver cholesterol

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0019] 1. Experimental materials and methods

[0020] 1.1 Drugs and reagents

[0021] Fresh litchi peel: purchased in Yanshan District, Guilin City, Guangxi in July 2013, identified as the peel of Sapindaceae litchi (litchi chinensis); simvastatin tablets: Guangdong Bidi Pharmaceutical Co., Ltd., batch number 20141002; total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDLC), low-density lipoprotein cholesterol (LDLC) assay kit: Changchun Huili; superoxide dismutase (SOD), malondialdehyde (MDA ), alanine aminotransferase (ALT), aspartate aminotransferase (AST), blood glucose (FBG), insulin (INS) assay kits: Nanjing Jiancheng; the rest of the reagents are domestic analytical grade.

[0022] 1.2 Instruments

[0023] TGL-16R high-speed refrigerated centrifuge, Zhuhai Heima Company; RT-9100 semi-automatic biochemical analyzer, Shenzhen Leidu Life Science Co., Ltd.; MK3 automatic microplate reader, Thermo Fisher (Shanghai) Instrument Co., Ltd. ; Ele...

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Abstract

The invention discloses the application of litchi peel polyphenols in the preparation of medicines or health care products for lowering liver cholesterol. The inventor found through a large number of experiments that polyphenols from lychee peel can effectively reduce liver cholesterol, liver triglyceride, and liver low-density lipoprotein cholesterol, thereby effectively reducing fat accumulation in the liver, and can be used to treat non-alcoholic fatty liver and other related liver diseases.

Description

technical field [0001] The invention belongs to the technical field of medical application of litchi, and in particular relates to the application of litchi skin polyphenols in the preparation of medicines or health care products for lowering liver cholesterol. Background technique [0002] Non-alcoholic fatty liver disease refers to a hereditary-metabolic-pathological clinical syndrome characterized by diffuse hepatic bullous steatosis, which is caused by alcohol and other definite liver-damaging factors. , The characteristics of continuous progression of the disease. The pathogenesis of non-alcoholic fatty liver is extremely complex, and the second-hit theory is more recognized. The first hit is insulin resistance, and the second hit mainly refers to oxidative stress and lipid peroxidation damage caused by various reasons. The formation of fatty liver is closely related to lipid metabolism disorder: the unbalanced synthesis and excretion of triglyceride (TG) and very low-...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/77A23L33/00A61P1/16A61K131/00
Inventor 李典鹏杨子明黄永林陈月圆张利刘金磊王磊颜小捷卢凤来
Owner GUANGXI INST OF BOTANY THE CHINESE ACAD OF SCI
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