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Application of icaritin to medicine for treating Alzheimer disease

An icariin, senile technology, applied in the field of medicine, can solve the problems of senile dementia without icariin, can not delay the course of the disease, etc.

Inactive Publication Date: 2015-09-09
ZUNYI NO 1 PEOPLES HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Cholinesterase inhibitors are currently the main drugs used to treat AD, which can significantly reduce the symptoms of AD, but cannot delay the course of the disease
At present, there is no research report on the effect of icariin on the treatment of senile dementia

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Embodiment 1 of the present invention: the application of icariin:

[0027] Take 200-2000 mg of icariin, 0.1-0.4 mg of sodium lauryl sulfate, 6-10 mg of starch, and 60-80 mg of microcrystalline cellulose, mix icariin with starch and microcrystalline cellulose, Sieve, mix well, add appropriate amount of water or ethanol to make granules, after drying, granulate, add sodium lauryl sulfate, and then press the granules into tablets with a punching device to obtain tablets for treating senile dementia. The tablet is taken orally, 3 times a day, 1-3 tablets each time.

Embodiment 2

[0028] Embodiment 2 of the present invention: the application of icariin:

[0029] Take 200-2000 mg of icariin, 0.1-0.3 mg of sodium lauryl sulfate, 6-10 mg of starch, and 60-80 mg of microcrystalline cellulose, and mix the icariin with starch and microcrystalline cellulose , adding an appropriate amount of ethanol to granulate, after drying, granulate, add sodium lauryl sulfate, and then add into gelatin capsules to obtain capsules for treating senile dementia. The capsules are taken orally, 3 times a day, 1-3 capsules each time.

Embodiment 3

[0030] Embodiment 3 of the present invention: the application of icariin:

[0031] Take 200-2000mg of icariin, add water to 1000ml, add 0.5% activated carbon, keep the pH value at 7.0, heat to a slight boil for 15 minutes, cool, filter, add water for injection to the full amount, fill, and sterilize at 115°C for 30 minutes Minutes, refrigerated for 48 hours, filtered, the filtrate was concentrated, spray-dried, subpackaged, and the injection for treating senile dementia was obtained. The preparation is for injection, once a day, 10-15 ml each time.

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PUM

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Abstract

The invention relates to an application of icaritin to a medicine for treating the Alzheimer disease. Icaritin is taken as a main raw herb, and a proper amount of auxiliary materials are added to prepare an oral preparation or an injection. By deep and detailed research of icaritin on aspects, such as a pharmacological action and an action mechanism, it is found that icaritin can obviously reduce Abeta aggregation and cholinergic nerve functional impairment, due to Abeta<25-35>, of a dementia rat model, and obviously improves the learning and memory dysfunction of the dementia rat model. Icaritin can reduce Abeta aggregation and improves the function of brain cholinergic nerve, produces a function of resisting Abeta<25-35> neurotoxicity, and obviously improves the learning and memory ability of the dementia rat model. According to the invention, by researching the effects of icaritin on the learning and memory ability, the cholinergic system, and an Abeta metabolic pathway of the dementia rat model, the pharmacological action mechanism of icaritin on treating the Alzheimer disease is illustrated, and pharmacological foundations on application of further developing icaritin are provided.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to the application of icariin in medicine for treating senile dementia. Background technique [0002] Alzheimer's disease (Alzheimer's Disease, AD) is a progressive brain degenerative disease that is common in the presenile and old age. The high mortality rate is the main cause of senile dementia, which seriously destroys the health of the elderly and adds a huge burden to the family and society. Previous studies have shown that the pathogenesis of AD may be related to gene defects, immune inflammation, metabolic disorders, cholinergic defects, free radical damage, neuronal apoptosis, and environmental toxins. The research on its pathogenesis mainly focuses on amyloid- β, Aβ) cascade reaction theory, cholinergic theory, excitotoxicity theory, etc. Among them, the Aβ cascade theory has been studied the most and can best reveal the main pathological features of AD, incl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/352A61P25/28
Inventor 罗勇
Owner ZUNYI NO 1 PEOPLES HOSPITAL
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