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Preparation and application of effective parts of platycladi seeds

A technology of effective parts and baiziren, applied in the field of medicine, can solve the problems of easy formation of drug resistance, obvious adverse reactions, and small toxic and side effects.

Inactive Publication Date: 2017-10-24
南京惠宝生物医药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above drugs can improve the symptoms of AD patients in the short term, but cannot alleviate the development of the disease, and are prone to drug resistance, with obvious adverse reactions; while traditional Chinese medicine has good clinical effects in the prevention and treatment of mild cognitive impairment and senile dementia. The characteristics of pathways and multi-link overall regulation, and the use of natural medicines has less toxic and side effects

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Example 1: Preparation process of the effective part of Baiziren

[0026] (1) Take 1000g of Boziren medicinal material, wash, dry, crush and pass through a 60-mesh sieve to obtain a coarse powder;

[0027] (2) Extract 10 times the amount of 75% ethanol with 75% ethanol, reflux at 60°C for 4 times, 4 hours each time, filter, combine the two filtrates, and concentrate the filtrate to obtain the extract;

[0028] (3) Add 4 times the amount of water to dissolve the obtained extract, and then adsorb it on a D101 macroporous resin column, then wash it with deionized water until the effluent is colorless, and then elute it with 95% ethanol solution;

[0029] (4) Combine the eluate purified by the macroporous resin, concentrate with a rotary evaporator, and evaporate to dryness under vacuum at 60°C to obtain the effective fraction of Cypress kernel.

Embodiment 2

[0030] Example 2: In vivo study proves that the effective part of Baiziren has therapeutic effect on APP / PS1 double transgenic dementia mice

[0031] 1 material

[0032] 1.1 Experimental animals

[0033] Forty-eight 5-month-old APP / PS1 double transgenic mice, male, weighing 25±2g, SPF grade, and 8 C57BL / 6J mice with the same genetic background were normal controls.

[0034] 1.2 Experimental drugs and reagents

[0035] The positive control drug is donepezil hydrochloride (trade name: Aricept), 5 mg / tablet, the tablet is ground into powder before use, and double-distilled water is used to make a drug solution for oral administration of 0.65 mg / kg d - 1 ; Huperzine A Capsules were prepared with double distilled water to make a drug solution for gastric administration, and the prepared concentration was 0.026mg / kg·d - 1 . Acetylcholinesterase (AChE) kit, choline acetyltransferase (ChAT) kit, SOD activity kit, MDA content kit, GSH content kit. The effective part of Baiziren is...

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Abstract

The invention relates to preparation and application of an effective parts of platycladi seeds. The invention is characterized in the application of the effective parts of the platycladi seeds to preparation of senile dementia preventing and treating medicines and health products, wherein the content of the effective part of the platycladi seed is not lower than 60%. Experimental research proves that the effective part of the platycladi seed can improve the memory disorder of a model animal and improve the learning and memory capability thereof; the effective part of the platycladi seed has the effects of reducing formation of senile plaques, effectively improving and regulating the central cholinergic nervous system, regulating metabolism of free radicals and the like; the effective part of the platycladi seed has an exact therapeutic effect on senile dementia, including Alzheimer's disease, vascular dementia, mixed dementia and the like.

Description

technical field [0001] The invention relates to the preparation and application of the effective part of the cypress kernel, in particular to the application of the effective part of the cypress kernel in medicines and health care products for preventing or treating senile dementia, belonging to the field of medicine. Background technique [0002] Senile dementia mainly includes Alzheimer's disease (AD) and vascular dementia (VD). Alzheimer's disease accounts for about 60-70%, and vascular dementia accounts for about 20-30%. Alzheimer's disease (AD) is a degenerative disease of the central nervous system mainly characterized by progressive dementia. Its clinical features are memory and other cognitive dysfunction, and early clinical symptoms include motor, sensory or coordination deficits. The main pathological changes in AD patients are senile plaques formed by extracellular amyloid deposition, neurofibrillary tangles, and loss of extensive neuronal synapses, inflammation,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/14A61P25/28A23L33/105
CPCA23V2002/00A61K36/14A61K2236/333A61K2236/39A61K2236/51A61K2236/53A61K2236/55A23V2200/30A23V2200/322A23V2250/21
Inventor 不公告发明人
Owner 南京惠宝生物医药有限公司
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