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Pharmaceutical composition for treating alzheimer disease

A technology for Alzheimer's disease and composition, applied in the field of medicine, to achieve the effect of increasing ACh content, reducing inflammation in the brain, and inhibiting the rate of apoptosis

Active Publication Date: 2015-05-13
南通大学技术转移中心有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The technical problem to be solved by the present invention is to combine the traditional Chinese medicine theory and the clinical characteristics of Alzheimer's disease in traditional Chinese medicine, according to the complex pathogenesis of Alzheimer's disease, aiming at its multiple pathogenesis links, to provide a drug with multi-target A traditional Chinese medicine composition that can effectively treat Alzheimer's disease

Method used

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  • Pharmaceutical composition for treating alzheimer disease
  • Pharmaceutical composition for treating alzheimer disease
  • Pharmaceutical composition for treating alzheimer disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] The preparation of embodiment 1 powder

[0031] Weigh 300g of Shouwu, 300g of Ganoderma lucidum, 200g of leeches, and 200g of Anemarrhena, add water and decoct twice, the first time for 2 hours, and the second time for 1.5 hours, combine the decoctions and let stand for precipitation, filter, and put the filtrate at 80°C Concentrate under reduced pressure to form a thick paste, dry below 80°C, pulverize, and sieve to obtain extract powder, add dextrin in an appropriate amount to dry, each g extract powder contains 2.5g of crude drug, and powder is obtained after crushing, the following "Yijing" Turn into turbid powder".

Embodiment 2

[0032] The preparation of embodiment 2 capsules

[0033] Weigh 300g of Shouwu, 200g of Ganoderma lucidum, 200g of leech, and 150g of Anemarrhena, add water and decoct twice, the first time for 2 hours, and the second time for 1.5 hours, combine the decoctions and let stand for precipitation, filter, and put the filtrate at 80°C Concentrate under reduced pressure to form a thick paste, dry below 80°C, pulverize, and sieve to obtain extract powder, add appropriate amount of auxiliary materials to dry, pulverize and put into gelatin capsules.

Embodiment 3

[0034] The preparation of embodiment 3 tablet

[0035] Weigh 100g of Shouwu, 100g of Ganoderma lucidum, 100g of leeches, and 150g of Anemarrhena, add water and decoct twice, the first time for 2 hours, and the second time for 1.5 hours, combine the decoctions and let stand for precipitation, filter, and put the filtrate at 80°C Concentrate under reduced pressure to form a thick paste, dry below 80°C, pulverize, and sieve to obtain extract powder, add appropriate amount of auxiliary materials, and press into tablets.

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Abstract

The invention discloses a pharmaceutical composition for treating alzheimer disease. The pharmaceutical composition is prepared from the following raw materials in parts by weight: 1-5 parts of processed radix polygoni multiflori preparata, 1-5 parts of ganoderma lucidum, 1-2 parts of leech and 1-2 parts of rhizoma anemarrhenae. A prescription is formed by combining the traditional theory of the traditional Chinese medicine with the medical clinical characteristics of the alzheimer disease (AD) and the pharmacology research method. A pharmacological study proves that the pharmaceutical composition has multi-component, multi-target point and multi-way action characteristics on treatment of the AD. The pharmaceutical composition disclosed by the invention is capable of obviously improving learning and memory capabilities of a plurality of mice or rat models of AD, has an obvious anti-inflammatory effect, and is capable of relieving free radical injuries, improving self-energy metabolic disturbance in the brain, obviously inhibiting the apoptosis rate of hippocampal neurons of the AD rats, and playing roles in protecting nerves and resisting dementia by a central cholinergic system.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a traditional Chinese medicine composition and its application for treating Alzheimer's disease. Background technique [0002] Alzheimer's disease (AD) is a degenerative disease of the central nervous system clinically characterized by progressive memory loss and dementia. With the extension of human life span, the incidence of AD has risen sharply. Due to the lack of effective treatment, AD has become the No. 4 killer of human beings after heart disease, cerebrovascular disease and cancer. Therefore, finding and developing drugs for the prevention and treatment of AD has become an urgent task, and research on the prevention and treatment of AD has become the primary research topic in the global medical community. [0003] The pathological features of AD are mainly senile plaques (senile plaques, SP), neurofibrillary tangles (neurofibrillary tangles, NFT) and neuro...

Claims

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Application Information

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IPC IPC(8): A61K36/8964A61P25/28A61K35/62
Inventor 周爱玲蒋伟张弦朱燕茅家慧胡亚娥耿劲松
Owner 南通大学技术转移中心有限公司
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