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Use of acetylcholine or acetylcholinesterase inhibitor in preparing medicine for treating fetal hypotension

A technology of acetylcholine and hypotension, applied in the field of biomedicine, can solve the problems of less clinical medicinal use and affecting the effect of the drug

Inactive Publication Date: 2017-12-08
THE FIRST AFFILIATED HOSPITAL OF SOOCHOW UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Because acetylcholine is easily decomposed by acetylcholinesterase in the tissue and affects the effect, it is rarely used as a clinical medicine

Method used

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  • Use of acetylcholine or acetylcholinesterase inhibitor in preparing medicine for treating fetal hypotension

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0021] Intravenous ACh increases fetal blood pressure: a sheep model, 10 animals.

[0022] ACh preparation: Calculate according to the administration of 40 μg per kg of fetal sheep, weigh the required ACh mass, dissolve in 1 mL of sterile water for injection, filter and sterilize, and prepare and use immediately.

[0023] ACh administration: After operation was performed on the fetal sheep, the femoral artery was isolated and cannulated, 1 mL of ACh solution was administered through the catheter artery, and the catheter was sealed with 2.5 mL of heparinized saline.

[0024] The inventor applied the intrauterine detection technology in the awake and stress-free state to pregnant sheep, and dynamically detected the changes in fetal blood pressure before and after direct ACh injection through arterial catheterization. figure 1 As shown, the basic blood pressure of fetal sheep is 52 mmHg. After intravenous injection of 160 μg ACh (based on the injection of 40 μg ACh per kg body we...

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Abstract

The invention belongs to the field of biomedicine and discloses the medicinal application of acetylcholine or acetylcholinesterase inhibitor in treating fetal hypotension. The present invention monitors blood pressure changes through intravenous injection of ACh and finds that ACh can slightly increase fetal blood pressure and heart function. Therefore, this patent aims to propose a new application of ACh, that is, to apply ACh to treat fetal hypotension caused by adverse intrauterine environment so as to improve the anti-oxygen therapy of the fetus and reduce the damage of various organs caused by fetal hypoxia. According to the curative effect, the new drugs that directly modify ACh and indirectly increase the content of ACh in the body are expected to slow down the fetal distress and increase the birth rate of healthy newborns.

Description

technical field [0001] The invention belongs to the field of biomedicine and relates to the medicinal use of acetylcholine or acetylcholinesterase inhibitors, in particular to the medicinal use of acetylcholine or acetylcholinesterase inhibitors in treating fetal hypotension. Background technique [0002] Acetylcholine (ACh) is a common neurotransmitter synthesized by choline and acetyl-CoA under the catalysis of choline acetyltransferase, and participates in nerve conduction in the autonomic nervous system and body motor nervous system. On the other hand, ACh also has an important impact on the cardiovascular system. It activates and binds to cholinergic receptors, activates downstream pathways, and causes peripheral and central vasodilation; it can also act on the sinus node to slow down heart rate and myocardial contraction. Decreased force and shortened atrial refractory period. Because acetylcholine is easily decomposed by acetylcholinesterase in the tissue and affects...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/221A61K31/27A61K31/445A61K31/55A61K31/4748A61K31/473A61P9/02
Inventor 徐智策孙淼茅彩萍周秀文吕娟秀高芹芹李凌君李娜汤佳奇尹晓会陶建英
Owner THE FIRST AFFILIATED HOSPITAL OF SOOCHOW UNIV
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