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Application of litchi rind polyphenol in preparation of medicine or health-care food for reducing low-density lipoprotein cholesterol of liver

A technology for low-density lipoprotein and health care products, which can be applied to drug combinations, medical preparations containing active ingredients, and pharmaceutical formulations, etc., and can solve problems such as failure to be effectively developed and utilized.

Active Publication Date: 2015-09-02
GUANGZHOU XIAOJING BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

During the deep processing of lychee, about 40% of the fresh fruit’s peel and stone waste are produced, and a large amount of lychee peel has not been effectively developed and utilized as a bulk agricultural product waste.

Method used

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  • Application of litchi rind polyphenol in preparation of medicine or health-care food for reducing low-density lipoprotein cholesterol of liver
  • Application of litchi rind polyphenol in preparation of medicine or health-care food for reducing low-density lipoprotein cholesterol of liver
  • Application of litchi rind polyphenol in preparation of medicine or health-care food for reducing low-density lipoprotein cholesterol of liver

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Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0019] 1. Experimental materials and methods

[0020] 1.1 Drugs and reagents

[0021] Fresh litchi peel: purchased in Yanshan District, Guilin City, Guangxi in July 2013, identified as the peel of Sapindaceae litchi (litchi chinensis); simvastatin tablets: Guangdong Bidi Pharmaceutical Co., Ltd., batch number 20141002; total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDLC), low-density lipoprotein cholesterol (LDLC) assay kit: Changchun Huili; superoxide dismutase (SOD), malondialdehyde (MDA ), alanine aminotransferase (ALT), aspartate aminotransferase (AST), blood glucose (FBG), insulin (INS) assay kits: Nanjing Jiancheng; the rest of the reagents are domestic analytical grade.

[0022] 1.2 Instruments

[0023] TGL-16R high-speed refrigerated centrifuge, Zhuhai Heima Company; RT-9100 semi-automatic biochemical analyzer, Shenzhen Leidu Life Science Co., Ltd.; MK3 automatic microplate reader, Thermo Fisher (Shanghai) Instrument Co., Ltd. ; Ele...

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Abstract

The invention discloses application of litchi rind polyphenol in preparation of a medicine or health-care food for reducing low-density lipoprotein cholesterol of the liver. Discovered by a large number of experiments, the litchi rind polyphenol obtained from litchi peels can reduce cholesterol, triglyceride and low-density lipoprotein cholesterol of the liver effectively, so that fat accumulation in the liver can be reduced effectively, and the litchi rind polyphenol can be applied to treatment of related liver diseases such as a non-alcoholic fatty liver disease.

Description

technical field [0001] The invention belongs to the technical field of medical applications of lychees, and in particular relates to the application of lychee skin polyphenols in the preparation of medicines or health care products for lowering liver low-density lipoprotein cholesterol. Background technique [0002] Non-alcoholic fatty liver disease refers to a hereditary-metabolic-pathological clinical syndrome characterized by diffuse hepatic bullous steatosis, which is caused by alcohol and other definite liver-damaging factors. , The characteristics of continuous progression of the disease. The pathogenesis of non-alcoholic fatty liver is extremely complex, and the second-hit theory is more recognized. The first hit is insulin resistance, and the second hit mainly refers to oxidative stress and lipid peroxidation damage caused by various reasons. The formation of fatty liver is closely related to lipid metabolism disorder: the unbalanced synthesis and excretion of trigl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/77A61P1/16A61K131/00
Inventor 杨子明李典鹏黄永林陈月圆王磊刘金磊卢凤来颜小捷张利
Owner GUANGZHOU XIAOJING BIOTECH CO LTD
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