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Moringa seed and novel use of moringa seed extract for medicine and health-care food capable of promoting learning memory

A technology of learning and memory, health food, applied in health food or food, Moringa seeds and their extracts can solve problems such as unclear improvement effect of learning and memory in the field of medicines for promoting learning and memory, and achieve the improvement of learning and memory loss, The effect of promoting learning and memory and reducing the number of mistakes

Inactive Publication Date: 2015-09-02
郑艳华 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the improvement effect of Moringa seed extract on learning and memory is not clear

Method used

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  • Moringa seed and novel use of moringa seed extract for medicine and health-care food capable of promoting learning memory
  • Moringa seed and novel use of moringa seed extract for medicine and health-care food capable of promoting learning memory
  • Moringa seed and novel use of moringa seed extract for medicine and health-care food capable of promoting learning memory

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Embodiment 1: the influence of Moringa oleifera seed ethanol extract on latency period, the number of times of mistakes in mouse avoidance test;

[0024] 1) 60 Kunming mice were randomly divided into 4 groups, each with 15 mice, respectively normal saline group, scopolamine 4 mg / kg group, Moringa seed ethanol extract 250 mg / kg+scopolamine 4 mg / kg group, spicy Wood seed ethanol extract 500 mg / kg + scopolamine 4 mg / kg group;

[0025] 2) Normal saline group and scopolamine 4 mg / kg group were given normal saline by intragastric administration at 15:00 every day for 3 days; Moringa seed 250 mg / kg+scopolamine 4 mg / kg group and Moringa seed ethanol extract 500 mg / kg+scopolamine 4mg / kg group was given ethanol extract of Moringa oleifera seed by intragastric administration at 15:00 every day for 3 days;

[0026] 3) On the 4th day, the drug was administered according to step 2, but except for the normal saline group, the other three groups were given scopolamine 4 mg / kg by intr...

Embodiment 2

[0028] Embodiment 2: Moringa oleifera seed ethanol extract is on the incubation period in the water maze test, the impact of platform crossing times and target quadrant dwell time;

[0029] 1) 60 Kunming male mice, 15-20g, were randomly divided into 4 groups, 15 in each group, respectively normal saline group, scopolamine 4 mg / kg group, Moringa seed ethanol extract 250 mg / kg+scopolamine 4 mg / kg group, Moringa seed ethanol extract 500 mg / kg+scopolamine 4 mg / kg group;

[0030] 2) The mice were first adapted to the environment for 2 days, and the administration began at 12 noon on the third day, and the administration was continued for 3 days (days 3, 4, and 5). The normal saline group and the scopolamine 4 mg / kg group were given physiological Saline, the latter two groups were given different doses of ethanol extracts of Moringa oleifera seeds by intragastric administration, and the dosage was 0.1ml / 10g;

[0031] 3) The water maze experiment was started on the 6th day, and the...

Embodiment 3

[0032] Embodiment 3: The effect of Moringa oleifera seed extract on scopolamine-induced mouse hippocampal acetylcholine content and acetylcholine transferase;

[0033] 1) 60 Kunming male mice, 15-20g, were randomly divided into 4 groups, 12 in each group, respectively normal saline group, scopolamine 4 mg / kg group, Moringa seed ethanol extract 250 mg / kg+scopolamine 4mg / kg kg group, Moringa seed ethanol extract 500 mg / kg+scopolamine 4 mg / kg group;

[0034] 2) The mice were first adapted to the environment for 2 days, and the administration began at 12 noon on the third day, and the administration was continued for 3 days (days 3, 4, and 5). The normal saline group and the scopolamine 4mg / kg group were given normal saline by intragastric administration , the latter two groups were given different doses of ethanol extracts of Moringa oleifera seeds by intragastric administration, and the dosage was 0.1 ml / 10g;

[0035]3) From the 6th day, continue to administer the drug accordin...

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Abstract

The invention discloses a moringa seed and novel use of a moringa seed extract for medicine, health-care food or food capable of promoting learning memory. Proved by a pharmacological experiment, when hyoscine is used for inducing learning amnesia hyoscine, the moringa seed extract is capable of improving an incubation period and reducing the amount of errors remarkably in an avoidance test, and improving an incubation period, increasing the amount of platform passing times and prolonging target quadrant stopping time of a mice remarkably in a water maze test; the moringa seed extract has an exact function of promoting learning memory and can be applied to improvement on learning memory amnesia caused by various reasons.

Description

technical field [0001] The present invention relates to the new medicinal application of plants, in particular to the application of Moringa oleifera seed and its extract as medicine, health food or food for promoting learning and memory. Background technique [0002] Learning and memory ability is one of the important brain functions that human beings depend on for survival. Learning is the process in which the nervous system acquires new behaviors and experiences by accepting changes in the external environment, and memory is the retention and reproduction of experiences after learning. Therefore, learning and memory are two interrelated processes that depend on the integration of whole brain functions. Memory is generally divided into three stages, namely acquisition, consolidation and reproduction. The internal psychological processes of humans and animals cannot be directly observed, and the processes occurring in the brain can only be speculated based on the observab...

Claims

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Application Information

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IPC IPC(8): A61K36/185A61P25/28A23L1/29
Inventor 金鑫杨立朝郑艳华庄信修
Owner 郑艳华
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