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Delphinidin complex as an antiphlogistic or immunosuppressive active ingredient

A technology of delphinidin and immunosuppressant, applied in fields including, can solve problems such as heart rhythm disorder and high blood pressure

Active Publication Date: 2015-08-26
SAPIOTEC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

long-term high blood pressure
Hydrocortisone, on the other hand, can cause heart rhythm disturbances

Method used

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  • Delphinidin complex as an antiphlogistic or immunosuppressive active ingredient
  • Delphinidin complex as an antiphlogistic or immunosuppressive active ingredient
  • Delphinidin complex as an antiphlogistic or immunosuppressive active ingredient

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0088] Preparation of test solution:

[0089] To determine the delphinidin content of a solid prepared according to the invention (see below for the preparation method), approximately 50 mg of this composition was weighed into a 10 mL flask. Subsequent dissolution was performed using Diluent 2, and dilution was continued with the same Diluent 2 until a delphinidin concentration of approximately 0.1 mg / mL was reached.

[0090] The delphinidin content in the samples was calculated with the aid of Agilent ChemStation software and calibrated using the external standards mentioned above.

example 1

[0091] Example 1: Complexation of delphinidin with SBE-β-CD

[0092] This example investigates the complexation of delphinidin with different cyclodextrins and the solubility of said complexes in aqueous solutions.

[0093] Firstly, a neutral aqueous solution of each cyclodextrin with a weight percentage of 10% was prepared. For β-CD, due to its low solubility, the selected concentration is only 2% by weight.

[0094] 5 mL of each cyclodextrin aqueous solution was poured into a glass flask and pure water was added. An excess of delphinidin chloride was subsequently added. The required additional amount is 10 mg for α-, β- and γ-cyclodextrin solutions and 15 mg for HPBCD (2-hydroxypropyl-β-cyclodextrin) and SBE-β-CD solutions.

[0095] The suspension was stirred for 20 hours at 30°C in the dark. Filtration was then performed using a membrane filter with a pore size of 0.22 μm.

[0096] The achievable solubilities are listed in Table 1 below:

[0097] Cyclodextrin...

example 2

[0099] Example 2: Effect of pH

[0100] This example investigates the effect of pH on the solubility of delphinidin-SBE-β-CD. An aqueous solution of SBE-β-CD was prepared as described in Example 1, and the solution was adjusted to the acidic pH values ​​described in Table 2 using 1 M HCL. Subsequently, delphinidin chloride was added and the operation continued as described in Example 1, with the only difference being that the shift time was reduced to 2.5 hours. The test results are listed in Table 2 below:

[0101] pH

[0102] It can be seen from the above table that when the pH value is between 4 and 5, the meridian-chelated delphinidin chloride is increased by about 2 times compared with that at neutral pH value.

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PUM

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Abstract

The invention relates to a composition comprising a complex of delphinidin and a sulfoalkyl ether β-cyclodextrin for use as an antiphlogistic and / or immunosuppressive.

Description

technical field [0001] The present invention involves including [0002] - complexes of delphinidin and thioalkylether-β-cyclodextrin and / or [0003] - Delphinidin or its salts [0004] Use of the composition as an anti-inflammatory and / or immunosuppressant. Background technique [0005] Immune system responses are regulated by components of the innate and adaptive immune systems. The innate nonspecific immune system includes all macrophage-, monocyte-, and granulocyte-based responses to antigenic and allogeneic stimuli (bacteria, viruses, fungi, etc.), as well as responses including interferons, defensins, and acute-phase proteins Humoral defense mechanisms. The adaptive or adaptive immune system includes all lymphocyte-based specific defense responses, especially B lymphocytes (B cells) and T lymphocytes (T cells). Under certain conditions, the immune system response may itself be the cause of the disease or disease-related state. Such diseases or states are, for exa...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7042A61K47/40A61P29/00A61P37/06
CPCA61K31/724A61K31/353A61K45/06A61K9/146A61K47/48969A61K9/08A61K47/40A61K31/352A61K47/6951A61P1/04A61P11/00A61P19/02A61P25/00A61P25/16A61P25/24A61P25/28A61P29/00A61P31/00A61P31/04A61P33/06A61P35/00A61P37/06A61P9/00A61P9/10Y02A50/30A61K2300/00
Inventor 诺伯特·若维尔延斯·布若斯凯特
Owner SAPIOTEC
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