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Method for preparing high-purity hydroxycitric acid with garcinia cambogia as raw material

A technology of hydroxycitric acid and calcium hydroxycitrate, which is applied in the field of preparing high-purity hydroxycitric acid, can solve problems such as difficult separation, non-biological activity, instability, etc., and achieves the stability of hydroxycitric acid, with simple and easy method and mild conditions Effect

Active Publication Date: 2015-08-19
义乌章舸生物工程有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Most foreign countries use chemical synthesis method: citric acid is dehydrated and oxidized with concentrated sulfuric acid to synthesize it. The hydroxycitric acid produced by this method has many by-products, is not easy to separate, and has great side effects.
However, the direct high temperature extraction of hydroxycitric acid from Garcinia cambogia is extremely unstable and can easily be converted into lactones with no biological activity during the extraction process.

Method used

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  • Method for preparing high-purity hydroxycitric acid with garcinia cambogia as raw material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] (1) Garcinia cambogia powder 1kg, add 30L CaCO with a mass concentration of 2% 3 Add 10 grams of activated carbon to the solution, the extraction temperature is 30°C, the high-shear extraction is 20 minutes, the high-shear motor speed is 5800 rpm, and the filter is filtered to obtain 30L of calcium hydroxycitrate filtrate.

[0034] (2) Filter the filtrate through a microfiltration-ultrafiltration combined equipment, the microfiltration membrane operating temperature is 30°C, the flow rate is an average of 10L / min, the inlet pressure is 0.25MPa, the outlet pressure is 1.1MPa, and the pore size of the microfiltration membrane is 0.2 microns; The ultrafiltration membrane temperature is 30°C, the flow rate is 4L / min, the operating pressure is 0.8MPa, and the molecular weight cut-off of the ultrafiltration membrane is 50000 Daltons; 28L of high-purity calcium hydroxycitrate filtrate is obtained.

[0035] (3) Add 1.5mol / L of H to the high-purity calcium hydroxycitrate filtrate 3 PO...

Embodiment 2

[0039] (1) Garcinia cambogia powder 1kg, add 20L CaCO with a mass concentration of 3% 3 The solution is added with 15 grams of activated carbon, the extraction temperature is 35°C, the high-shear extraction is 20 minutes, the high-shear motor speed is 7000 rpm, and it is filtered to obtain 20L of calcium hydroxycitrate filtrate.

[0040] (2) Filter the filtrate through a combined microfiltration-ultrafiltration device. The operating temperature of the microfiltration membrane is 30°C, the average flow rate is 15L / min, the inlet pressure is 0.25MPa, the outlet pressure is 1.1MPa, and the pore size of the microfiltration membrane is 0.8 microns; The ultrafiltration membrane temperature is 30°C, the flow rate is 5L / min, the operating pressure is 0.8MPa, and the molecular weight cut-off of the ultrafiltration membrane is 5000 Daltons; 19.8L of high-purity calcium hydroxycitrate filtrate is obtained.

[0041] (3) Add 1mol / L of H to the high-purity calcium hydroxycitrate filtrate 3 PO 4 2...

Embodiment 3

[0045] (1) Garcinia cambogia powder 1kg, add 40L CaCO with a mass concentration of 1.5% 3 The solution is added with 20 grams of activated carbon, the extraction temperature is 35°C, the high-shear extraction is 30 minutes, the high-shear motor speed is 8000 rpm, and filtered to obtain 20L of calcium hydroxycitrate filtrate.

[0046] (2) Filter the filtrate through a combined microfiltration-ultrafiltration device. The operating temperature of the microfiltration membrane is 40℃, the average flow rate is 15L / min, the inlet pressure is 0.25MPa, the outlet pressure is 1.1MPa, and the pore size of the microfiltration membrane is 0.45 microns; The ultrafiltration membrane temperature is 40°C, the flow rate is 5.4L / min, the operating pressure is 0.8MPa, and the molecular weight cut-off of the ultrafiltration membrane is 20,000 Daltons; 36.5L of high-purity calcium hydroxycitrate filtrate is obtained.

[0047] (3) Add 1mol / L of H to the high-purity calcium hydroxycitrate filtrate 3 PO 4 2...

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Abstract

The invention discloses a method for preparing high-purity hydroxycitric acid with garcinia cambogia as a raw material, wherein the method comprises the following steps: (1) crushing garcinia cambogia into a coarse powder, adding 20-40 L of a CaCO3 solution and 10-20 g of activated carbon into 1 kg of the garcinia cambogia coarse powder, carrying out low-temperature high-shear extraction, filtering, and thus obtaining a calcium hydroxycitrate solution A; (2) carrying out microfiltration and ultrafiltration on the calcium hydroxycitrate solution A, to obtain a calcium hydroxycitrate solution B; (3) adding a phosphoric acid solution into the calcium hydroxycitrate solution B, stirring evenly, and carrying out nanofiltration desalting, to obtain a hydroxycitric acid concentrated solution; and (4) carrying out cooling crystallization on the hydroxycitric acid concentrated solution, carrying out centrifugal separation, and thus obtaining a high-purity hydroxycitric acid crystal powder. The method is simple and feasible to implement, suitable for industrialized production and mild in conditions, the hydroxycitric acid is stable in the extraction process, and the hydroxycitric acid obtained from extraction is high in purity.

Description

Technical field [0001] The invention relates to the technical field of plant extraction, in particular to a method for preparing high-purity hydroxycitric acid using Garcinia cambogia as a raw material. Background technique [0002] Hydroxycitric acid, English name: Hydroxycitric.acid, synonym: 2-hydroxycitric acid; 1,2-dihydroxy-1,2,3-propane tricarboxylic acid, molecular formula: C 6 H 8 O 8 , The structural formula is as follows: [0003] [0004] Garcinia cambogia is native to Asia, South Africa and Polynesia. The active ingredient is hydroxycitric acid, an edible fruit peel extract. This substance plays a different role in metabolism than citrate, and has been proven to accelerate fat metabolism and inhibit The synthesis of fatty acids and cholesterol in humans or organisms. Commonly used hydroxy citrate, in human metabolism, it can replace citrate to competitively inhibit fatty acid synthesis. [0005] Modern medicine proves that hydroxycitric acid can effectively increase th...

Claims

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Application Information

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IPC IPC(8): C07C59/245C07C51/42
CPCC07C51/42C07C59/245
Inventor 丁舸
Owner 义乌章舸生物工程有限公司
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