A kind of production method of high-purity metformin hydrochloride
A technology of metformin hydrochloride and its production method, which is applied in the field of synthesis of pharmaceutical chemicals, can solve problems such as difficult control of production operations, strict equipment material requirements, and large proportion of raw materials, and achieve shortened product refining cycle, fast drying speed, and raw material conversion rate-enhancing effect
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Embodiment 1
[0047] 1. Add solvent and solute to the synthesis kettle
[0048]The synthesis kettle used is a 1000L glass-lined kettle. The solvent N-methylpyrrolidone 600Kg is sucked into the synthesis kettle by vacuum, the stirring is started, and the solute dicyandiamide 250Kg and dimethylamine hydrochloride 250Kg are added.
[0049] 2. Stir
[0050] (1) Stirring for the first time
[0051] Open the steam valve, turn on the steam to raise the temperature, and use a frequency converter to adjust the stirring speed to 50-60 rpm.
[0052] (2) Second heating
[0053] Stir for 15-20 minutes to raise the temperature of the synthesis kettle to 62°C.
[0054] (3) Adjust the vacuum degree for the first time
[0055] Turn on the vacuum pump, adjust the vacuum degree in the synthesis kettle to 0.04MPa, and continue stirring for 10-20 minutes after the vacuum degree is stable.
[0056] (4) Three heating times
[0057] Open the large steam valve, continue to heat up, and stir for 15-20 minutes...
Embodiment 2
[0093] The preparation steps of Example 1 are adopted, and the solvent used is the mother liquor produced in the spin-drying step of Example 1, which is put into a centrifuge from the synthesis kettle and then reused to prepare metformin hydrochloride.
Embodiment 3
[0095] Using the preparation steps of Example 1, the solvent used is the mother liquor produced in the spin-drying step of Example 2, which is put into a centrifuge from the synthesis kettle and continued to be reused to prepare metformin hydrochloride.
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