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Titanium and tantalum composite microsphere bone filling medical material

A composite microsphere, titanium and tantalum technology, applied in the field of biomedical engineering, can solve the problems of low strength and stiffness, and achieve high strength, excellent biocompatibility, osteoconductivity, and high elastic modulus

Inactive Publication Date: 2015-07-22
SHANGHAI JIAO TONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to overcome the deficiency of low strength and rigidity of the existing human bone defect repair materials, and provide a titanium-tantalum composite microsphere bone filling medical material, which can significantly improve the strength and rigidity on the basis of maintaining excellent osteoconductivity, and Provide sufficient surface porous layer to facilitate subsequent functional improvements such as bioactive coatings, introduction of osteoinductive factors, loading of strontium elements, loading of antibacterial silver ions, loading of anti-inflammatory or anti-tumor drugs, etc., so that it has high Strength, long fatigue life in biological environment, sufficient stiffness and excellent bone conduction performance

Method used

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  • Titanium and tantalum composite microsphere bone filling medical material
  • Titanium and tantalum composite microsphere bone filling medical material
  • Titanium and tantalum composite microsphere bone filling medical material

Examples

Experimental program
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Effect test

Embodiment 1

[0026] Use 0.05mm tantalum wire to wind porous tantalum microspheres with a porosity of 10% and a diameter of 1mm, and then inject the titanium alloy melt into the porous tantalum microspheres to prepare titanium-tantalum composite microspheres with a diameter of 1mm. The volume ratio of the two phases is: titanium / tantalum=0.1:0.9, the surface thickness of the microsphere is about 0.2mm, the porosity is 10%, and the inner space is coated with surface bioactivity. The compressive strength of the microspheres reaches 150MPa; the elastic modulus reaches 30GPa.

Embodiment 2

[0028] Use 1mm tantalum wire to wind porous tantalum microspheres with a porosity of 50% and a diameter of 10mm, and then inject titanium melt into the porous tantalum microspheres to prepare titanium-tantalum composite microspheres with a diameter of 10mm, wherein the core of the microspheres is composed of two phases The volume ratio is: titanium / tantalum=0.5:0.5, the surface thickness of the microsphere is about 1.5mm, the porosity is 50%, and the inner space is loaded with growth-promoting strontium elements and antibacterial silver ions. The compressive strength of titanium-tantalum composite microspheres reaches 100MPa; the modulus of elasticity reaches 20GPa.

Embodiment 3

[0030] A 0.1mm tantalum alloy wire is used to wind a porous tantalum microsphere with a porosity of 90% and a diameter of 3mm, and then the molten titanium is injected into the porous tantalum microsphere to prepare a titanium-tantalum composite microsphere with a diameter of 3mm. The volume ratio of the phases is: titanium / tantalum=0.9:0.1, the surface thickness of the microsphere is about 0.5mm, the porosity is 90%, and the inner space is loaded with osteoinductive factors and anti-inflammatory drugs. The compressive strength of titanium-tantalum composite microspheres reaches 20MPa; the modulus of elasticity reaches 5GPa.

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Abstract

A titanium and tantalum composite microsphere bone filling medical material is characterized in that the bone filling medical material is a titanium and tantalum composite microsphere, the titanium and tantalum composite microsphere comprises a microsphere core made of a titanium / tantalum two-phase composite material and a microsphere surface formed by a winding tantalum porous layer, the titanium / tantalum two-phase composite material is formed through the steps of preparing a porous microsphere by braiding medical tantalum or tantalum alloy wires, injecting a liquid titanium or titanium alloy melt into the center of the porous microsphere, cooling and solidifying, and the microsphere surface includes a space for surface bioactive coating and medicine loading. The titanium and tantalum composite microsphere bone filling medical material substantially improves the strength and rigidity of the bone filling medical material, realizes high fatigue life in biological environment, maintains excellent biocompatibility and bone conduction, provides enough space and possibility for medicine loading and loading of bone inducement factors, and is suitable for various bone filling, restoration, reconstruction and other orthopedic clinic applications under minimal invasion conditions.

Description

technical field [0001] The invention relates to a medical bone filling material, in particular to a titanium-tantalum composite microsphere bone filling medical material, which belongs to the technical field of biomedical engineering. Background technique [0002] The Chinese patent with the publication number CN101584880 provides a material for the repair of human bone defects, which includes a fibrous porous titanium microsphere and a nano-strontium apatite layer; the fibrous porous titanium microsphere is made of pure titanium fibers, The composite effect of porous titanium microspheres composed of fibers and nano-strontium apatite layer to repair bone defects can promote the adhesion, proliferation and differentiation of osteoblasts on the basis of maintaining the original fibrous porous materials, and at the same time more effectively induce bone formation. [0003] However, due to the limitations of its material structure, the strength and stiffness of the above-menti...

Claims

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Application Information

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IPC IPC(8): A61L27/50A61L27/06A61L27/56A61L27/04A61L27/54
Inventor 何国
Owner SHANGHAI JIAO TONG UNIV
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