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Preparation process of azlocillin sodium for injection

A technology of azlocillin sodium and preparation process, which is applied in the field of preparation technology of azlocillin sodium for injection, can solve the problems of reducing the medicinal effect of azlocillin sodium for injection and the like, and achieve the effects of accelerating mixing speed and improving efficiency

Inactive Publication Date: 2015-07-15
SICHUAN PHARMA
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] The technical problem to be solved by this invention is to provide a kind of preparation technology of azlocillin sodium for injection, to overcome the reduction of the medicinal effect of azlocillin sodium for injection caused by the preparation technology of existing azlocillin sodium for injection question

Method used

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Embodiment

[0021] The preparation technology of azlocillin sodium for injection comprises the following steps:

[0022] (1) Synthesis of azlocillin sodium: Mix dichloromethane and ampicillin at a weight ratio of 1:0.065, adjust the pH of the solution to be alkaline, obtain a condensation reaction solution, and mix 1-chloroformyl-2 - Imidazolidinone and dichloromethane are put into the above condensation reaction solution, and the weight ratio of 1-chloroformyl-2-imidazolidinone, dichloromethane and condensation reaction solution is 1:4.6:28.5; the pH of the adjustment solution is weak Alkaline, continue to stir to get the condensation reaction material, use water to extract and separate the above condensation reaction material one by one, transfer the water layer to the crystallization tank, adjust the pH with acid, centrifuge the crystals after crystallization, wash and dry the crystals Azlocillin, the azlocillin is dissolved in the water in the tank under the condition that the cooling...

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Abstract

The invention relates to a preparation process of azlocillin sodium for injection. The preparation process comprises the following steps: synthesizing azlocillin sodium; and drying the synthesized azlocillin sodium, and preparing into powder, wherein the preparation process of the azlocillin sodium powder comprises the following steps: firstly, cleaning a reagent bottle for containing the azlocillin sodium powder, then quantitatively filling the azlocillin sodium powder into the cleaned reagent bottle according to a specification, filling nitrogen, then covering the bottle by using a pretreated rubber plug, then performing cover tying treatment by using an aluminum cover to ensure that the product is sealed, then sequentially performing inner label pasting, packaging and lamp inspection on the reagent bottle subjected to cover tying, then pasting an outer label on a packing box, and then performing inspection and packaging. The preparation process provided by the invention overcomes the problem that the existing preparation process of azlocillin sodium for injection reduces the medicinal effect of the azlocillin sodium for injection.

Description

technical field [0001] The invention relates to the field of preparation technology of medical drugs, in particular to a preparation technology of azlocillin sodium for injection. Background technique [0002] Azlocillin sodium, its chemical name is: (2S,5R,6R)-3,3-Dimethyl-6-[(R)-2-(2-oxo-1-imidazolidinecarboxamido)- 2-benzacetylamino]-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid sodium salt. [0003] Azlocillin sodium was first developed by Bayer Company of Germany. It went on the market in May 1977. Since the 1980s, it has been used in the United States, Britain and other countries. In 1983, it was included in the supplementary volume of the 20th edition of the US Pharmacopoeia. However, it is recorded that its bactericidal effect on Pseudomonas aeruginosa is about ten times greater than that of carbenicillin, and it also has the effect of ampicillin on Gram-positive bacteria, and it retains the activity of carbenicillin on intestinal bacteria, so from Sinc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/14A61K31/431A61P31/04A61J3/02C07D499/68C07D499/16
Inventor 刘萍王强张静文
Owner SICHUAN PHARMA
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