Polysaccharide styptic powder, preparation method thereof and application

Abstract

The invention relates to polysaccharide styptic powder, a preparation method thereof and an application. The preparation method comprises the following steps of using plant native starch and etherified starch as raw materials; treating the plant native starch and the etherified starch by using a microwave oven and glycerol; performing emulsion dispersion on the plant native starch and the etherified starch by using span 80, tween 80 and vegetable oil under the conditions that the pH (potential of hydrogen) is 9-10 and the temperature is 45-70 DEG C; performing crosslinking on the plant native starch and the etherified starch by using sodium trimetaphosphate; performing extraction and skimming on the plant native starch and the etherified starch by using ethyl acetate; washing the plant native starch and the etherified starch by using absolute ethyl alcohol; and drying the plant native starch and the etherified starch by using an oven and performing sterilization so as to obtain the polysaccharide styptic powder. The polysaccharide styptic powder has high biocompatibility, can be directly used for stopping general bleeding, deep bleeding and bleeding of parts at which a surgical tool cannot reach, and is easy and convenient to use. The starch serves as the raw materials of the styptic powder and is non-toxic and non-irritant, the sources of the starch are extensive, the cost is low, a technology is simple and feasible, and the polysaccharide styptic powder has a wide clinical application prospect.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and in particular relates to a polysaccharide hemostatic powder and a preparation method and application thereof. Background technique [0002] Bleeding is one of the problems that need to be solved urgently in surgery. The normal human body has the function of hemostasis. Slow and small amount of bleeding can be stopped by its own function. The body cannot stop the bleeding by itself, nor can it only be stopped by ordinary hemostatic bandages. Excessive bleeding during the operation will prolong the operation time, and serious complications will occur, such as hemorrhagic shock, which may even endanger life and health. Currently, the commonly used effective hemostasis method is to use biocompatible absorbable materials to stop bleeding. It is particularly important to provide a safe, effective, easy-to-use, and low-cost hemostatic material in hemostasis such as surgery and first aid. [0003...

AI Technical Summary

Problems solved by technology

[0003] At present, the clinically used hemostatic materials mainly include fibrin glue, collagen, gelatin sponge and cellulose hemostatic materials. These materials have achieved good results in animal experiments and clinical applications, but there are also some shortcomings: The raw material is derived from animal tissue, which is a foreign protein, which is prone to rejection and has potential sensitization; gelatin absorbs slowly, generally more than 4 weeks, which will increase the risk of wound infection; cellulose, the human body lacks enzymes to degrade it , the degradation time is long, which may bring side effects such as infection to the patient

At present, the representative starch hemostatic material is Arista hemostatic powder produced in the United States. Although its hemostatic effect is good, it is cross-linked with epichlorohydrin, which is potentially toxic and expensive, which limits its application.