Applications of expression vector carrying light-sensing ion channel protein encoding gene in preparation of respiratory rhythm regulating and controlling drug

Abstract

Embodiments of the invention provide applications of an expression vector carrying a light-sensing ion channel protein encoding gene in preparation of a respiratory rhythm regulating and controlling drug. According to the present invention, the respiratory rhythm regulating and controlling drug provides effects for gamma-GABAergic nerve fibers in thalamus anterior nucleus so as to effectively slow down the respiration rate and make breath be uniform; and tidal respiration, sighing respiration and other diseases related to unstable respiratory rhythm can be effectively improved, the body can be controlled to stably intake a proper amount of oxygen so as not to intake excessive oxygen and too little carbon dioxide, the always exciting of the respiratory center is ensured, the early prevention is provided so as to avoid the apnea phenomenon, and safety and reliability are provided.

Description

technical field [0001] The invention relates to the application of an expression vector carrying a gene encoding a light-sensitive ion channel protein in the preparation of drugs for regulating respiratory rhythm. Background technique [0002] Breathing is a kind of rhythmic movement. At present, the study believes that the breathing rhythm is produced by the respiratory nerve cell group in the respiratory center, participates in the regulation and improvement of the breathing rhythm, and realizes the normal breathing movement of the body together. Due to organ damage such as heart and lung failure, tracheal blockage, pneumothorax, high cerebral pressure and reduced sensitivity to carbon dioxide, etc., the respiratory rhythm is damaged, and shallow and fast breathing, deep and slow breathing, apnea, tidal breathing, Sighing breathing, etc., can lead to serious consequences such as respiratory acidosis, alkalosis, respiratory arrest and death. In traditional treatment method...

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Problems solved by technology

In addition, continuous stimulation of the phrenic nerve can lead to fatigue of the diaphragm. After a long period of time, the respiratory volume will decrease, which will still cause hypoventilation, which is not ideal for the improvement of the previous symptoms.

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