Method for preparing antibacterial surface on medical high polymer material surface

A polymer material and surface modification technology, applied in the field of preparing antibacterial surfaces, can solve the problems affecting the surface antibacterial performance, antibacterial adhesion ability and sterilization ability, etc., to avoid mutual interference of performance, excellent biocompatibility, excellent The effect of long-lasting antibacterial properties

Active Publication Date: 2015-06-17
CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] The present invention aims to solve the problem that the anti-bacterial adhesion brush and the bactericidal brush introduced on the surface of medical materials in the prior art affect each other between the anti-bacterial adhesion ability and the bactericidal ability in the single-layer brush on the material surface, thereby affecting the antibacterial performance of the surface Technical problem, provide a method for preparing an antibacterial surface on the surface of a medical polymer material

Method used

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  • Method for preparing antibacterial surface on medical high polymer material surface
  • Method for preparing antibacterial surface on medical high polymer material surface
  • Method for preparing antibacterial surface on medical high polymer material surface

Examples

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Embodiment 1

[0038] Plasma pretreatment of medical polypropylene film, the working parameters are: power 90W, pressure 30Pa, gas flow rate 30cc / min, temperature 30°C, time 2min; then the sample was placed in 5.0wt% p-chloromethylbenzoyl chloride In an anhydrous solution, react at 25°C for 8h; then place the sample in an ethanol solution of 10.0wt% sodium diethyldithiocarbamate, and react at a reaction temperature of 30°C for 24h; then place the sample at 15.0wt% In the aqueous solution of monopolyethylene glycol acrylate, a 300W high-pressure mercury lamp was irradiated for 6 minutes; then the sample was washed with ethanol and deionized water for 25 minutes successively under the condition of oscillating in a water bath with a frequency of 120; then the sample was placed in 10.0wt% methacrylic acid In the aqueous solution of amide group quaternary ammonium salt, 300W high-pressure mercury lamp irradiates 4min, finally on the surface of medical polypropylene film, the antibacterial surface ...

Embodiment 2

[0045] Perform plasma pretreatment on the surface of medical polymer materials, and its working parameters are: power 20W, pressure 5Pa, gas flow rate 2cc / min, temperature 10°C, time 10min; then the sample is placed in 2.0wt% p-chloromethylphenyl In an anhydrous isocyanate solution, react at 10°C for 24h; then place the sample in an ethanol solution of 2.0wt% sodium dimethyldithiocarbamate, and react at a temperature of 20°C for 48h; then place the sample in 4.0wt% formaldehyde In the aqueous solution of acryloyloxyphosphorylcholine, a 500W high-pressure mercury lamp was irradiated for 3 minutes; then the sample was washed with ethanol and deionized water for 20 minutes in a water bath with a frequency of 120; then the sample was placed in 2.0wt% methyl In the aqueous solution of acrylamide-based quaternary ammonium salt, a 500W high-pressure mercury lamp is irradiated for 2 minutes, and finally an antibacterial surface co-modified by the bottom layer of the anti-bacterial adhe...

Embodiment 3

[0047] Perform plasma pretreatment on the surface of medical polymer materials, and its working parameters are: power 800W, pressure 120Pa, gas flow rate 500cc / min, temperature 45°C, time 1min; then the sample is placed in 20.0wt% o-chloromethylphenyl In an anhydrous trichlorosilane solution, react at 40°C for 2h; then place the sample in an ethanol solution of 20.0wt% sodium diisopropyldithiocarbamate, and react at a temperature of 50°C for 6h; then place the sample at 60.0 In an aqueous solution of wt% acryloyloxycarboxybetaine, irradiate with a 30W high-pressure mercury lamp for 120 minutes; then the sample was washed with ethanol and deionized water for 30 minutes in a water bath with a frequency of 120; then the sample was placed in a 30.0wt% In the aqueous solution of methacrylamide-based quaternary ammonium salt, 30W high-pressure mercury lamp is irradiated for 40 minutes, and finally an antibacterial surface co-modified by anti-bacterial adhesion brush bottom layer and ...

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Abstract

The invention relates to a method for preparing a surface, which is jointly modified by double layers of brushes comprising antibacterial adhesion brushes on the bottom layer and bactericidal brushes on the upper layer, on the surface of a medical high polymer material surface, and solves the technical problem that the antibacterial adhesion capacity and the bactericidal capacity influence each other, which is caused by the fact that antibacterial adhesion brushes and bactericidal brushes are introduced on a medical material surface, so that the surface antibacterial property is influenced in the prior art. The method comprises the following steps: a photo-initiation-transfer-termination polymerizer is introduced on the medical high polymer material surface, at first, the antibacterial adhesion brushes are grafted, then the bactericidal brushes are grafted, and a dual-layer dual-function antibacterial surface comprising the bottom layer provided with the antibacterial adhesion brushes and the upper layer provided with the bactericidal brushes is prepared on the material surface. Since the antibacterial adhesion brushes and the bactericidal brushes are positioned in different grafting layers, the mutual interference on performance is avoided, the synergistic effect of the antibacterial adhesion brushes and the bactericidal brushes endows the surface with superior long-acting antibacterial capability, the bad influence of a sterilizing layer on blood and body cells is relieved, and good biocompatibility can be obtained.

Description

technical field [0001] The invention relates to a method for preparing an antibacterial surface on the surface of a medical polymer material, in particular to a method for preparing a surface co-modified by a bottom layer of an anti-bacterial adhesion brush and an upper layer of a sterilizing brush on the surface of a medical polymer material. Background technique [0002] The commonly used methods for preparing antibacterial surfaces on the surface of medical materials include inactive antibacterial methods and active antibacterial methods. The inactive antibacterial method is to modify the surface of medical materials with anti-adhesive substances to inhibit the initial bacterial adhesion. The initial adhesion of live bacteria to the surface of a material is a necessary condition for biofilm formation. There are many factors that affect bacterial adhesion. In addition to bacterial surface characteristics and environmental factors, it is also related to the hydrophilicity ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J7/18C08J7/12
Inventor 栾世方殷敬华石恒冲闫顺杰袁帅帅
Owner CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
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