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A kind of preparation method of drug preparation for female menopause depression

A technology of pharmaceutical preparations and depression, which is applied in the field of preparation of pharmaceutical preparations for female menopausal depression, can solve the problems of western medicines such as large toxic and side effects, easy repetition of drug withdrawal, and insignificant therapeutic effects, etc., achieves small toxic and side effects, relieves anxiety, and regulates reproduction endocrine effects

Active Publication Date: 2017-11-10
海门市创豪工业设计有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Its purpose is to solve the problem of treating female menopausal depression, overcoming the side effects of western medicine, easy to repeat drug withdrawal, and insignificant therapeutic effect, so as to achieve the goal of treating both symptoms and root causes

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] A preparation method for female climacteric depression preparation, which is prepared from the following raw materials in weight ratio:

[0032] 35 parts of medlar, 35 parts of rehmannia, 35 parts of angelica, 30 parts of dodder, 30 parts of Anemarrhena,

[0033] Polygala 25, Poria 25, Morinda officinalis 25, Epimedium 20, Cnidium 20,

[0034] 20 parts of Chuanxiong, 15 parts of paeonol, 15 parts of Corydalis, 15 parts of Uncaria, 10 parts of mulberry,

[0035] 10 parts of Rhizoma Cyperi, 10 parts of Coix Seed, 10 parts of Angelica dahurica, 10 parts of Citrus aurantium, 8 parts of Polygonum multiflorum,

[0036] 8 parts of turmeric, 8 parts of Albizia Julibrissin, 5 parts of jujube seed, 5 parts of licorice, and 5 parts of hawthorn.

[0037] Its preparation method is:

[0038] 1) take each raw material and set aside;

[0039] 2) Take medlar, angelica, dodder, polygala, morinda officinalis, epimedium, chuanxiong, uncaria, angelica, aurantium citrus, turmeric, and al...

Embodiment 2

[0044]Acute toxicity test: 40 mice, half male and half female, weighing 30-40g, were subjected to acute toxicity test. The mice were randomly divided into 2 groups, i.e. a control group and a drug administration group (medicine preparation prepared in Example 1), 20 in each group, fasted for 12 hours before the experiment, and the drug administration group was given the drug prepared in Example 1 of the present invention The preparation was dissolved in water and administered by intragastric administration (a single administration dose of intragastric administration was 50g of crude drug / kg), and the control group was given the same amount of normal saline, administered twice a day, with an interval of 6 hours between administrations, and observed continuously for 14 hours after administration. days, and recorded the number of toxic reactions and deaths of the mice. The results of the experiment showed that compared with the control group, there was no significant difference i...

Embodiment 3

[0049] clinical information

[0050] The clinical data selected 102 clinical patients from the gynecological outpatient department of the hospital, aged 45-60 years, and were randomly divided into two groups: the treatment group and the control group were 51 cases. Statistical processing, no significant difference (P> 0.05), comparable.

[0051] Inclusion criteria: (1) Meet the relevant criteria of endogenous depression in the diagnostic criteria for functional mental disorders research and depressive episodes in the revision of the Chinese Mental Illness Classification Scheme and Diagnostic Criteria (2nd Edition); (2) Hamilton Depression Scale (HAMD, 24 items) the total score of the first seven items is ≥18 points; (3) no various organ diseases, endocrine, nervous system diseases, and severe malnutrition, while excluding those who are pregnant, breast-feeding, and drug abusers; (4) at least 1 Have not taken hormone drugs, contraceptives, and nerve blockers within one month, ...

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PUM

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Abstract

The invention relates to a method for preparing a pharmaceutical preparation for women's menopausal depression. The pharmaceutical preparation is prepared from the following raw materials: medlar, rehmannia glutinosa, angelica, dodder, anemarrhena, polygala, poria cocos, morinda officinalis, epimedium Husband, Cnidium, Chuanxiong, Paeonol, Corydalis, Uncaria, Mulberry, Cyperus Cyperi, Coix Seed, Angelica, Citrus Aurantium, Polygonum Multiflori, Curcuma, Albizia Flower, Jujube Seed, Licorice, Hawthorn. Prepare dosage forms such as capsules, tablets, and granules according to conventional pharmaceutical methods. The pharmaceutical preparation prepared by the method of the invention can treat both symptoms and root causes of female menopausal depression, has no side effect, is low in price, is easy to prepare, and has broad application prospects.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine preparations, and in particular relates to a preparation method of a drug preparation for female menopausal depression. Background technique [0002] Menopausal depression is a syndrome caused by factors such as mental anxiety, tension, and depression. The first onset age of menopausal depression is between 45 and 55 years old. Disappointed, often crying, blaming oneself, making subjective assumptions, suspecting others, or suspecting that one has a certain disease, especially "fear of cancer", and even lead to self-injury, suicide and other behaviors. In addition, there may be irregular menstruation, loss of libido, or sweating, fear of cold, weight loss, fatigue and other symptoms. Depression is a major global mental health problem. Its etiology is complex and has not yet been fully elucidated. With the intensification of competition in modern society, people's psychologica...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/9066A61P25/24A61P15/12
Inventor 陈明友
Owner 海门市创豪工业设计有限公司
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