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Traditional Chinese medicine dry suspension and preparation method thereof

A dry suspension, traditional Chinese medicine technology, applied in the field of traditional Chinese medicine dry suspension and its preparation, can solve the problems of poor patient compliance, large drug particle size, increased drug particle size, etc., and achieves a wide range of applications and improved evaluation index results. Effect

Inactive Publication Date: 2015-05-27
TIANJIN UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to many technical difficulties in the development of dry suspensions of traditional Chinese medicines, there are few researches and reports on dry suspensions of traditional Chinese medicines: first, the drug particle size of Chinese medicine extracts is large, which is higher than the conventional particle size range for preparing dry suspensions; secondly , the taste of traditional Chinese medicine extracts is generally not good. If the taste masking treatment is not carried out, the patient's compliance will be poor. If the taste masking treatment is carried out, the particle size of the medicine will be further increased; Taste-masking excipients may interact with dry suspension excipients and affect the quality of the dry suspension

Method used

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  • Traditional Chinese medicine dry suspension and preparation method thereof
  • Traditional Chinese medicine dry suspension and preparation method thereof
  • Traditional Chinese medicine dry suspension and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0073] Embodiment 1: preparation of Chinese medicine extract

[0074] 1. Prescription:

[0075] Psoralen 100kg, Eucommia 200kg, Salvia miltiorrhiza 200kg, Anemarrhena 100kg

Embodiment 4

[0076] 2. Preparation method: (prepared according to the method in Example 4 of Chinese patent application 201310524167.3)

[0077] Add 2 times the amount of 70% ethanol to the prescribed amount of psoralen decoction pieces and soak for 12 hours, then use 70% ethanol for percolation extraction, control the flow rate at 8mL / min / Kg, and collect 15 times the volume of psoralen feeding volume percolation liquid. Recover ethanol from the percolation solution under reduced pressure, concentrate to 1:1.5 (weight of medicinal material: volume of concentrated solution, m:v), refrigerate and stand for stratification, pour off the upper layer (recover under reduced pressure to obtain dry ointment powder), and take the lower layer to obtain Psoralen thick extract.

[0078] The prescribed amount of Danshen decoction slices was soaked in 2 times the amount of 95% ethanol for 24 hours, and extracted by percolation with 95% ethanol at a flow rate of about 16ml / kg.min. Ethanol is recovered fr...

Embodiment 2

[0082] Embodiment 2: Preparation of taste-masking traditional Chinese medicine powder

[0083] 1. Prescription

[0084] Chinese herbal extract powder 320g, Eudragit EPO 40g

[0085] Two. Method

[0086] Disperse the taste-masking excipient Eudragit EPO with water to prepare a taste-masking coating liquid, slowly add the Chinese medicine extract powder obtained in Embodiment 1, stir for 30 minutes, spray dry, collect the powder, and pass it through a 65-mesh sieve to obtain a taste-masking Chinese medicine powder.

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Abstract

The invention discloses a traditional Chinese medicine dry suspension and a preparation method thereof, belonging to the field of pharmaceutical preparation. The traditional Chinese medicine dry suspension consists of bitter taste masking traditional Chinese medicine powder, xanthan gum, RC-A591NF. According to the invention, bitter taste masking treatment is performed on traditional Chinese medicine extract, the sedimentation ratio of the finally obtained traditional Chinese medicine dry suspension can reach 0.9-1.0, the medicine content uniformity is good, rheological property research shows that the traditional Chinese medicine dry suspension is pseudoplastic fluid, according to a taste evaluation test, the dry suspension has no bad taste, the palatability is good, and the dry suspension can be accepted by a patient easily.

Description

technical field [0001] The invention relates to a traditional Chinese medicine dry suspension and a preparation method thereof, belonging to the field of pharmaceutical preparations. Background technique [0002] Chinese patent application 201310524167.3 (publication number CN103550484A) discloses a pharmaceutical composition for regulating estrogen level, its preparation method and application. The medicinal composition comprises psoraleae extract and extracts of eucommia ulmoides, salvia miltiorrhiza and anemarrhena anemarrhena, and can be effectively used for preventing and treating diseases related to estrogen level imbalance in the body or improving the symptoms thereof. In the composition, Eucommia ulmoides, Salvia miltiorrhiza, and Anemarrhena three herbs are combined and extracted with water, and the extraction amount of various chemical components (medicinal components, such as mangiferin, pinoresinol diglycoside, salvianolic acid B, etc.) is the highest, and the am...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8964A61K9/14A61K47/32A61K47/38A61K47/36A61P5/24
Inventor 王亚静高秀梅胡利民任树龙王文津朱光媚
Owner TIANJIN UNIV OF TRADITIONAL CHINESE MEDICINE
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