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Anatomical composite three-dimensional scaffold tissue engineering cartilage and preparation method thereof

A tissue engineering, three-dimensional scaffold technology, applied in medical science, prosthesis, etc., can solve the problems of poor stability, easy inactivation, limited effectiveness, etc., to achieve good biocompatibility and degradability, good biological Mechanical properties, the effect of completely healing cartilage damage

Inactive Publication Date: 2015-05-20
HANGZHOU CITY XIAOSHAN DISTRICT TRADITIONAL CHINESE MEDICAL HOSPITAL
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Problems solved by technology

However, exogenous IGF-I is expensive, poor in stability, short in vivo half-life, poor in biofilm permeability, and easily inactivated in a free state, thus limiting its effectiveness.

Method used

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  • Anatomical composite three-dimensional scaffold tissue engineering cartilage and preparation method thereof
  • Anatomical composite three-dimensional scaffold tissue engineering cartilage and preparation method thereof
  • Anatomical composite three-dimensional scaffold tissue engineering cartilage and preparation method thereof

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Experimental program
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Embodiment Construction

[0030] 1. Preparation method of finished composite scaffold

[0031] The present invention uses the anatomical shape composite three-dimensional bracket successfully developed by our research group in the early stage. Specific preparation process: Use CAD software to design and modify the three-dimensional rabbit femoral metaphysis and articular surface solid model (such as figure 2 , image 3 shown), the modified data is stored in STL format. Input the modified 3D data in STL format into a 3D printer, and use liquid PCL-HA composite material with a HA mass fraction of 20% as the raw material to print a 3D anatomical composite 3D scaffold layer by layer (such as Figure 4 , Figure 5 shown). The prepared scaffolds were washed three times with deionized water, 15 min each time; washed once with acetone (15 min); dried in vacuum at 45°C for 24 h, set at 105°C for 24 h, sterilized by ethylene oxide, and vacuum-packed. Refrigerate at -4°C for later use.

[0032] 2. Prep...

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Abstract

The invention relates to an anatomical composite three-dimensional scaffold tissue engineering cartilage and a preparation method thereof. According to the anatomical composite three-dimensional scaffold tissue engineering cartilage, a scaffold is made of polycaprolactone-hydroxyapatite composite material; IGF-1 PLGA microspheres are carried on the scaffold; and the adding amount of the IGF-1 PLGA microspheres is 0.1%-2% of the weigh of the scaffold. The novel three-dimensional porous scaffold prepared by the method has good biocompatibility and biodegradability and is free of cytotoxicity, can be gradually degraded along with regeneration of normal cartilage tissues after being implanted into a living body, and is finally replaced with regenerated cartilage, so that the target of thoroughly healing cartilage injuries is reached.

Description

technical field [0001] The invention relates to an anatomical composite three-dimensional scaffold tissue engineered cartilage and a preparation method thereof. Background technique [0002] As a basic pathological process, articular cartilage damage is involved in the early stages of pathological changes in almost all common clinical joint diseases, such as traumatic arthritis, osteoarthritis, rheumatoid arthritis, and femoral head necrosis. Although these joint diseases have completely different causes of disease and different pathological changes, they all show the same pathological process in the early stage of the disease, that is, the pathological changes of the articular cartilage. How to control the degree of cartilage damage in the early stage of joint disease, stop further cartilage damage or even complete wear as soon as possible, and intervene as early as possible to promote the repair of cartilage tissue is the key to the treatment of such joint diseases. Howev...

Claims

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Application Information

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IPC IPC(8): A61L27/46A61L27/54A61L27/56A61L27/58A61L27/50
Inventor 黄忠名李俊华汤样华胡文跃全仁夫
Owner HANGZHOU CITY XIAOSHAN DISTRICT TRADITIONAL CHINESE MEDICAL HOSPITAL
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