Eureka AIR delivers breakthrough ideas for toughest innovation challenges, trusted by R&D personnel around the world.

Preparation method of high-purity pyrimethanil and equipment used for preparing high-purity pyrimethanil

A pyrimethamine, high-purity technology, applied in the field of pesticide preparation, can solve the problems that it is difficult to meet the requirements, the original drug product cannot meet the requirements, etc., and achieves the effects of reducing the solubility, reducing the generation of acetone, and reducing hydrolysis.

Active Publication Date: 2015-05-13
利民化学有限责任公司
View PDF6 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The original drug products made by traditional technology cannot meet the requirements, and even the refined method is difficult to meet the requirements once, so the pyrimethanil products produced by traditional technology will gradually be eliminated

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Preparation method of high-purity pyrimethanil and equipment used for preparing high-purity pyrimethanil
  • Preparation method of high-purity pyrimethanil and equipment used for preparing high-purity pyrimethanil
  • Preparation method of high-purity pyrimethanil and equipment used for preparing high-purity pyrimethanil

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] in each batch

[0038] Aniline: 16.4Kmol (99%)

[0039] Hydrochloric acid: 15.7Kmol (30%)

[0040] Cyanamide: 16.6Kmol (30%)

[0041] Sodium carbonate: 16.4Kmol (99%)

[0042] Acetylacetone: 19.7Kmol (99%)

[0043] Feed nitrogen into the reaction kettle, replace the oxygen in the reaction kettle (oxygen content ≤ 2%), add 16.4Kmol aniline to the reaction kettle, start stirring after the aniline is added, raise the temperature to 50°C, and drop Add 11.8Kmol of hydrochloric acid once, control the reaction temperature at 50-60°C, and finish the dropwise addition in 1 hour. After the dropwise addition, raise the temperature to 80°C, start dropping 8.3Kmol of cyanamide once, and control the temperature at 80-85°C. Cyanamide, control the temperature at 85-90°C. After the dropwise addition, raise the temperature to 100°C, and keep the temperature for 5 hours; after the heat preservation reaction, cool to 60°C, put the prepared saturated sodium carbonate solution (50°C) i...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a preparation method of high-purity pyrimethanil. The method comprises the following steps: by taking phenylamine, hydrochloric acid, hydrogen cyanamide, sodium carbonate and acetylacetone as raw materials, charging nitrogen to protect during the whole process, adding hydrochloric acid and hydrogen cyanamide twice respectively, and strictly controlling the molar amount of hydrochloric acid to synthesize phenylguanidine carbonate; carrying out cyclization dehydration on the obtained phenylguanidine carbonate and acetyl benzophenone to prepare pyrimethanil. The invention further discloses equipment for preparing high-purity pyrimethanil by using the preparation method of high-purity pyrimethanil.

Description

technical field [0001] The invention relates to the field of pesticide preparation, in particular to a preparation process and equipment for the fungicide pyrimethanil. Background technique [0002] Pyrimethanil is a pyrimidine amine fungicide developed by German Agford Company. Its chemical name is N-(4,6-dimethylpyrimidine-ethyl)aniline. It is mainly used to prevent gray mold and scab of various crops. It is an excellent broad-spectrum, high-efficiency, low-toxicity, systemic fungicide, and has achieved remarkable results in crop sterilization and yield increase. Therefore, pyrimethanil is the first choice of fungicides in countries all over the world. [0003] The original drug is colorless crystal or white crystal, soluble in organic solvents, slightly soluble in water, solubility in water at room temperature (25°C) is 0.12Kg / L, melting point at 25°C is 96.3°C (pure product), vapor pressure 2.2×10 -3 Pa (25°C), stable under weak acid and weak alkaline conditions, speci...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): C07D239/42
CPCC07D239/42
Inventor 孙敬权唐启举
Owner 利民化学有限责任公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com