Separation and purification method of valine

Abstract

The invention discloses a separation and purification method of valine. The separation and purification method comprises the following steps: (1) performing frame filtering on valine fermentation liquid to obtain filtered solutions, and feeding the filtered solutions into a cation exchange resin column, which rotates from right to left, of a continuous moving bed; (2) sequentially dividing the cation exchange resin column of the continuous moving bed into a feeding area, a material washing area, a back-washing area, a product water ejection area, a first analyzing area, a second analyzing area, an analyzing solution recovery area, an acid regeneration area and a washing acid area from right to left, and collecting the analyzing solutions of the first analyzing area and the second analyzing area and applying the analyzing solutions to production of medicine-level valine products and food-level valine products. The yield of the valine obtained by using the method can reach about 98 percent.

Description

technical field [0001] The invention belongs to the technical field of fermentation amino acid separation, and in particular relates to a method for separation and purification of valine. Background technique [0002] Valine is one of the 20 kinds of amino acids that make up protein. Its chemical name is 2-amino-3-methylbutyric acid. It belongs to branched-chain amino acids and is also 8 kinds of amino acids necessary for human body. The human body cannot produce valine itself and must be supplemented through dietary sources. Its natural food sources include grains, dairy, shiitake, mushrooms, peanuts, soy protein, and meat. Valine plays a very important role in metabolism because of its special structure and function. It works together with two other high-concentration amino acids (isoleucine and leucine) to promote normal body growth, repair tissues, and regulate blood sugar , and provide the required energy. When participating in strenuous physical activity, valine can...

AI Technical Summary

Problems solved by technology

It is difficult to remove miscellaneous acids in production. Miscellaneous acids such as lysine and alanine can be removed through repeated concentration and crystallization, while leucine needs to be removed through the difference in the resolution speed of leucine and valine during the separation process. Removal, its separation properties are similar to chromatographic separation, the separation is difficult, and it is a key point in the production of pharmaceutical-grade valine products. The separation effect and valine yield of the existing technology are still not ideal

Images