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Ceftiofur hydrochloride powder injection and its preparation method and application

A technology of ceftiofur hydrochloride and ceftiofur, which is applied in powder transportation, freeze-drying transportation, digestive system, etc., can solve the problems of ceftiofur sodium, such as strong hygroscopicity, easy to be degraded by moisture, easy to be degraded by moisture, etc., to achieve no Effects of incompatibility, increased feed intake, and broad market prospects

Active Publication Date: 2017-07-21
广东省天宝生物制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, ceftiofur sodium has strong hygroscopicity, and is easily degraded by moisture, deteriorated and smelly, and its solubility decreases.
[0004] In view of the disadvantages of ceftiofur sodium due to its strong hygroscopicity and easy moisture degradation and deterioration, the existing veterinary ceftiofur sodium powder injections must be made into freeze-dried powder injections, and the raw materials and their preparations must be stored at a low temperature of 4-10 °C, etc. These problems of existence urgently need to develop a kind of veterinary ceftiofur hydrochloride powder injection that raw material and preparation thereof all can be stored at room temperature
And, at present, there is no report on the application of ceftiofur hydrochloride powder injection for veterinary use at home and abroad.

Method used

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  • Ceftiofur hydrochloride powder injection and its preparation method and application
  • Ceftiofur hydrochloride powder injection and its preparation method and application
  • Ceftiofur hydrochloride powder injection and its preparation method and application

Examples

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Comparison scheme
Effect test

Embodiment 1

[0027] A preparation method of ceftiofur hydrochloride powder injection, comprising the following steps: weighing ceftiofur hydrochloride and sodium carbonate at a weight ratio of 48 (calculated as the active ingredient ceftiofur):28, and putting it into SYH-100 three-dimensional motion In the mixer, after mixing for 15 minutes, transfer to the KGL-120 type antibiotic glass bottle screw dispensing machine for subpackaging to obtain ceftiofur hydrochloride powder injection. The volume of each bottle is 0.1g, 0.2g, 0.5g or 1.0g (both based on the active ingredient ceftiofur), of which, 0.1g and 0.2g specifications are packed in 5-7mL vials, and 0.5g specifications are used in 10-15mL Divided into vials, 1.0g in 20-25mL vials.

[0028] The particle size of ceftiofur hydrochloride is 60-100 mesh.

[0029] The particle size of sodium carbonate is 60-100 mesh.

[0030] The above operations are all carried out in the powder injection purification workshop, and the cleanliness requi...

Embodiment 2

[0032] A preparation method of ceftiofur hydrochloride powder injection, comprising the following steps: weighing ceftiofur hydrochloride and sodium carbonate at a weight ratio of 50:31 (calculated as the active ingredient ceftiofur), and putting them into a SYH-100 three-dimensional motion In the mixer, after mixing for 15 minutes, transfer to the KGL-120 type antibiotic glass bottle screw dispensing machine for subpackaging to obtain ceftiofur hydrochloride powder injection. The volume of each bottle is 0.1g, 0.2g, 0.5g or 1.0g (both based on the active ingredient ceftiofur), of which, 0.1g and 0.2g specifications are packed in 5-7mL vials, and 0.5g specifications are used in 10-15mL Divided into vials, 1.0g in 20-25mL vials.

[0033] The particle size of ceftiofur hydrochloride is 60-100 mesh.

[0034] The particle size of sodium carbonate is 60-100 mesh.

[0035] The above operations are all carried out in the powder injection purification workshop, and the cleanliness r...

Embodiment 3

[0037] A preparation method of ceftiofur hydrochloride powder injection, comprising the following steps: weighing ceftiofur hydrochloride and sodium carbonate at a weight ratio of 52:34 (calculated as the active ingredient ceftiofur), and putting them into a SYH-100 three-dimensional motion In the mixer, after mixing for 15 minutes, transfer to the KGL-120 type antibiotic glass bottle screw dispensing machine for subpackaging to obtain ceftiofur hydrochloride powder injection. The volume of each bottle is 0.1g, 0.2g, 0.5g or 1.0g (both based on the active ingredient ceftiofur), of which, 0.1g and 0.2g specifications are packed in 5-7mL vials, and 0.5g specifications are used in 10-15mL Divided into vials, 1.0g in 20-25mL vials.

[0038] The particle size of ceftiofur hydrochloride is 60-100 mesh.

[0039] The particle size of sodium carbonate is 60-100 mesh.

[0040] The above operations are all carried out in the powder injection purification workshop, and the cleanliness r...

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Abstract

The invention belongs to the technical field of veterinary medicines, and particularly relates to a ceftiofur hydrochloride powder injection as well as a preparation method and an application thereof. The ceftiofur hydrochloride powder injection is prepared from the following effective components ceftiofur hydrochloride and a cosolvent at the weight ratio of (48-52) to (28-34). Ceftiofur sodium is replaced with the ceftiofur hydrochloride; veterinary cefepime hydrochloride powder injection is prepared by weighing the effective components and the cosolvent at the weight ratio of (48-52) to (28-34), mixing evenly, and sub-packaging; and the veterinary cefepime hydrochloride powder injection can be produced and stored at a room temperature. According to the ceftiofur hydrochloride powder injection, the problems that an existing veterinary cefepime hydrochloride powder injection needs to be produced by a freeze-drying method, the raw materials and the preparation need to be stored at a low temperature of 4-10 DEG C, the placement time in a room-temperature or high-temperature season is overlong, and the medication effect is poor due to degradation are solved; the prepared powder injection has the same antibacterial effect as a ceftiofur sodium freeze-dried powder injection; and the ceftiofur hydrochloride powder injection is low in cost and wide in application prospect.

Description

technical field [0001] The invention belongs to the technical field of veterinary medicine, and in particular relates to a veterinary ceftiofur hydrochloride powder injection and a preparation method and application thereof. Background technique [0002] Ceftiofur is a bactericidal broad-spectrum antibiotic for veterinary medicine. It is a cephalosporin antibiotic in β-lactam antibiotics. It can kill a variety of Gram-positive and Gram-negative bacteria. It is one of the clinically widely used antibiotics. one. In veterinary medicine, ceftiofur sodium is generally used to make freeze-dried powder injections, and ceftiofur hydrochloride is used to make oily suspension injections, etc., which are used for bacterial respiratory tract infections in pigs and other livestock, as well as E. coli and salmonella in chickens and other poultry. infection. [0003] At present, ceftiofur sodium freeze-dried powder injection has the best application effect in veterinary medicine, and th...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/19A61K31/546A61P31/04A61P11/00A61P13/00A61P15/00A61P17/00A61P1/16A61P11/02A61P11/04A61P27/16
Inventor 李国清戴述诚
Owner 广东省天宝生物制药有限公司
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