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Veterinary enrofloxacin injection and preparation method thereof

A technology of enrofloxacin and injection, applied in the field of veterinary drug preparation, can solve the problems of poor stability, low cure rate, short duration of drug effect, etc. Effect

Inactive Publication Date: 2015-05-06
PIZHOU ZHENGKANG BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

And at present the enrofloxacin injection commercially available in the prior art has low cure rate, short drug effect period, poor stability and high cost

Method used

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  • Veterinary enrofloxacin injection and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] (1) Take 1% of polyvinylpyrrolidone, 1.5% of benzyl alcohol, 40% of propylene glycol and appropriate amount of water for injection according to the aforementioned weight percentages and add them to the concentrated mixing tank, and heat to 60°C with steam;

[0031] (2) Dissolve 0.1% of anhydrous sodium sulfite and 0.01% of EDTA-2Na with an appropriate amount of water for injection, and add them to the concentrated mixing tank under stirring;

[0032] (3), add enrofloxacin 2.5% of the aforementioned weight percentage, L-arginine base 10%, stir to dissolve;

[0033] (4), adjust the pH value to 9.5-10.5 with 10% sodium hydroxide aqueous solution, filter to dilute the tank, add water for injection to the full amount;

[0034] (5) The intermediate is qualified, finely filtered, filled with nitrogen and sealed, then steam sterilized at 115°C for 30 minutes, cooled to room temperature, packed, and put into storage for inspection.

Embodiment 2

[0036] (1) Take 1.5% of polyvinylpyrrolidone, 3% of benzyl alcohol, 35% of propylene glycol and appropriate amount of water for injection according to the aforementioned weight percentages and add them to the concentrated mixing tank, and heat to 60°C with steam;

[0037] (2) Dissolve 0.15% of anhydrous sodium sulfite and 0.015% of EDTA-2Na with an appropriate amount of water for injection, and add them to the concentrated preparation tank under stirring;

[0038] (3), add enrofloxacin 5%, L-arginine alkali 15% of aforementioned weight percentage, stir to dissolve;

[0039] (4), adjust the pH value to 9.5-10.5 with 15% sodium hydroxide aqueous solution, filter to dilute the tank, add water for injection to the full amount;

[0040] (5) The intermediate is qualified, finely filtered, filled with nitrogen and sealed, then steam sterilized at 115°C for 30 minutes, cooled to room temperature, packed, and put into storage for inspection.

Embodiment 3

[0042] (1) Take 1.8% of polyvinylpyrrolidone, 5% of benzyl alcohol, 30% of propylene glycol and appropriate amount of water for injection according to the aforementioned weight percentages and add them to the concentrated mixing tank, and heat to 60°C with steam;

[0043] (2) Dissolve 0.18% of anhydrous sodium sulfite and 0.018% of EDTA-2Na with an appropriate amount of water for injection, and add them to the concentrated preparation tank under stirring;

[0044] (3), add the enrofloxacin 10% of aforementioned weight percentage, L-arginine base 20%, stir to dissolve;

[0045] (4), adjust the pH value to 9.5-10.5 with 20% sodium hydroxide aqueous solution, filter to dilute the tank, add water for injection to the full amount;

[0046] (5) The intermediate is qualified, finely filtered, filled with nitrogen and sealed, then steam sterilized at 115°C for 30 minutes, cooled to room temperature, packed, and put into storage for inspection.

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Abstract

The invention discloses veterinary enrofloxacin injection and a preparation method thereof, belonging to the technical field of preparation of veterinary drugs. The veterinary enrofloxacin injection is prepared from the following raw materials in percentage by weight: 2-20 percent of enrofloxacin, 2-30 percent of L-arginine alkali, 10-30 percent of a pH value regulator, 0.1-0.2 percent of an antioxidant, 0.01-0.02 percent of a chelating agent, 10-50 percent of an organic solvent, 1-13 percent of a cosolvent, 1-5 percent of a controlled release formulation and the balance of water for injection. The veterinary enrofloxacin injection is high in stability, low in cost and safe and convenient to use and has the advantages of long-acting effect, high efficiency and low drug tolerance. Moreover, the veterinary enrofloxacin injection is compatible with L-arginine alkali to achieve a special effect of treating mixed infection caused by sensitive bacteria and mycoplasma of beasts and birds.

Description

technical field [0001] The invention relates to a veterinary enrofloxacin injection, in particular to a veterinary enrofloxacin injection and a preparation method thereof, belonging to the technical field of veterinary drug preparation. Background technique [0002] Enrofloxacin is a synthetic third-generation quinolone antibacterial drug, also known as ethyl ciprofloxacin. It is a special antibacterial drug for animals and has attracted much attention from the veterinary field. It was successfully developed in my country in 1993 and has been widely used in veterinary medicine. clinical. Enrofloxacin can accumulate in macrophages, which is 2 to 3 times the blood concentration, and it can be quickly released from the inflammatory site to play an anti-inflammatory and bactericidal effect. Enrofloxacin is mainly excreted through the kidneys, followed by the liver, and the main metabolites are the original form and ciprofloxacin. Enrofloxacin and its metabolite ciprofloxacin wo...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K31/496A61P31/04A61K31/198
Inventor 王书平田勇张家铭王真真李灿
Owner PIZHOU ZHENGKANG BIOTECH
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