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Preparation and application of polyelectrolyte/silver halide nanocomposite antibacterial material

A technology of nanocomposites and polyelectrolytes, applied in applications, botany equipment and methods, animal repellants, etc., can solve the problems of long-acting antibacterial, easy loss, low rate, etc., and achieve great practical significance and Economic value, good alcohol solubility effect

Inactive Publication Date: 2015-04-29
QINGDAO INST OF BIOENERGY & BIOPROCESS TECH CHINESE ACADEMY OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, some polymer materials that have been reported to release bactericidal "silver" have shown good bactericidal effect, but the disadvantage of these materials is that the silver element contained in this type of polymer exists in simple form, so the release The rate of bactericidal silver ion is very low; Or realize bactericidal effect by releasing the mode of water-soluble silver salt, but because silver ion dissolves in water, it is easy to run off, and this makes it difficult to reach the effect of long-acting antibacterial, and this is exactly the present invention key issues to be addressed

Method used

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  • Preparation and application of polyelectrolyte/silver halide nanocomposite antibacterial material
  • Preparation and application of polyelectrolyte/silver halide nanocomposite antibacterial material
  • Preparation and application of polyelectrolyte/silver halide nanocomposite antibacterial material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Example 1: Preparation of 9,9-disubstituted-2,7-diboronate fluorene

[0025] Take the preparation of 9,9-dibromohexyl-2,7-diboronate fluorene as an example to illustrate (see attached image 3 ):

[0026] Weigh fluorene (6g, 36mmol) and dissolve it in chloroform (40ml), add iron powder (32.5mg, 0.58mmol), cool in an ice bath, slowly add a mixture of liquid bromine (5ml) and chloroform (5ml), dropwise After completion, keep the low temperature reaction for 3 hours. After the reaction, add sodium bisulfite aqueous solution to remove excess bromine, extract with dichloromethane, wash the organic phase with water, dry over night with anhydrous sodium sulfate, evaporate the solvent, and then recrystallize with chloroform to obtain white crystal product 2, 7-Dibromofluorene.

[0027] Put 2,7-dibromofluorene (3.24g, 10mmol), tetrabutylammonium bromide (0.64g, 2mmol), dimethyl sulfoxide (50ml), potassium hydroxide aqueous solution (50ml, 50%) in three ports of 250ml A s...

Embodiment 2

[0029] Example 2: Preparation of N-substituted-3,6-diboronate carbazole

[0030] Take the preparation of 3,6-diboronate-N-bromohexylcarbazole as an example to illustrate (see the attached Figure 4 ):

[0031] Carbazole (12.54g, 75mmol), carbon disulfide (375ml) and anhydrous pyridine (24ml) were put into a reaction flask, cooled in an ice bath, and liquid bromine (28.30g, 177mmol) was slowly added dropwise. After the dropwise addition, the ice bath device was removed, the temperature was gradually raised to 15°C, and the mixture was stirred at 15°C for 2.5 hours. After the reaction, the reaction solution was poured into dilute hydrochloric acid, a pale yellow precipitate formed, filtered, washed with dilute sodium hydroxide solution 3 times, then washed with distilled water until neutral, and dried. Recrystallize with absolute ethanol and dry to obtain white needle-like crystals, which is the target product 3,6-dibromocarbazole.

[0032]Weigh 3,6-dibromocarbazole (5g, 15...

Embodiment 3

[0034] Example 3: Preparation of N-substituted-2,6-diboronate bithienopyrrole

[0035] Take the preparation of 2,6-diboronate-N-bromohexylbithienopyrrole as an example to illustrate (see the attached Figure 5 ):

[0036] Weigh 3,3'-dibromo-2,2'-bithiophene (2g, 6.18mmol), sodium tert-butylate (1.42g, 14.8mmol), Pd 2 dba 3 (0.142g, 0.155mmol) was dissolved in toluene (12ml). After stirring for 20 minutes, n-hexylamine bromide (1.11 g, 6.18 mmol) was added. Under the protection of argon, it was heated to 110°C and reacted for 7 hours. After the reaction, it was cooled to room temperature, and the organic phase was separated, extracted with dichloromethane, washed with water, and dried overnight with anhydrous sodium sulfate. The solvent was removed and separated by column chromatography to obtain the product N-bromohexylbithienopyrrole.

[0037] Weigh N-bromohexylbithienopyrrole (0.51g, 1.5mmol) and dissolve it in chloroform (20ml), add NBS (0.831g, 4.67mmol), and reac...

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Abstract

A silver ion bactericide has a broad-spectrum antibacterial effect and avoids drug resistance as well as strain variation of microorganisms. Therefore, silver ions are currently an important research direction of the biomedical technology industry. According to the invention, an in-situ synthesis method is adopted for the first time to prepare a conductive conjugate polyelectrolyte / silver halide nanocomposite; and a long-acting broad-spectrum antibacterial effect is realized by adopting a silver halide nanocomposite taking the conductive conjugate polyelectrolyte as a carrier as a broad-spectrum antibacterial material and controlling the size of the silver halide nanoparticles complexed in the conductive conjugate polyelectrolyte to regulate the release rate of silver ions. In the invention, the application of the conductive conjugate polyelectrolyte in biomedicine and particularly the antibacterial field is exploited, and an antibacterial material which avoids toxic and side effects to a human body and is easy to spray and regulate and convenient to use is provided; and the antibacterial material has a broad application prospect in various conduits (catheters and air ducts), dressings and preparations as well as the long-acting mould and bacteria prevention of precise instruments.

Description

technical field [0001] The present invention relates to polyelectrolytes, including but not limited to quaternary ammonium salt cationic water-soluble or alcohol-soluble polyelectrolytes. [0002] The polyelectrolytes involved in the present invention include, but are not limited to, conductive conjugated polyelectrolytes. [0003] The invention also relates to the respective synthetic preparation of the polyelectrolytes. [0004] The invention also relates to the preparation of polyelectrolyte and silver halide respectively to form nanocomposite material. [0005] The invention also relates to the application of the composite material in the antibacterial field. Background technique [0006] An electrolyte is a compound that can conduct electricity in an aqueous solution or in a molten state. [0007] Polyelectrolytes, also known as polymer electrolytes, are a class of linear or branched synthetic and natural water-soluble polymers whose structural units contain ionizabl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08L65/00C08K3/16C08G61/12A01N25/10A01N59/16A01P1/00
Inventor 阳仁强郭静周远航
Owner QINGDAO INST OF BIOENERGY & BIOPROCESS TECH CHINESE ACADEMY OF SCI
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