Application of isoflavonoids in preparation of medicine for treating multiple sclerosis diseases

A technology for multiple sclerosis, isoflavones, applied in the field of natural medicinal chemistry and medicine

Inactive Publication Date: 2015-04-29
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0013] But so far no irisin (1), irisxanthin (2), irisin-4'-O-β-D-glucoside (3), irisinin (4), irisin (5) Reports on the prevention or treatment of depression-like behaviors and learning and memory impairments caused by multiple sclerosis

Method used

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  • Application of isoflavonoids in preparation of medicine for treating multiple sclerosis diseases
  • Application of isoflavonoids in preparation of medicine for treating multiple sclerosis diseases
  • Application of isoflavonoids in preparation of medicine for treating multiple sclerosis diseases

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Embodiment 1

[0043] Embodiment 1: Application of irisaxanthin and irisin in the preparation of medicines for the treatment of multiple sclerosis

[0044] 1 Experimental drugs and animals

[0045] 1.1 Experimental drugs and preparation: irisxanthin and irisin were dissolved in DMSO to an initial concentration of 0.6 g / ml, and then diluted to 3 mg / ml with normal saline before intraperitoneal injection every day for intraperitoneal injection.

[0046] 1.2 Modeling drugs and preparation: dicyclohexanone oxalyldihydrazone (CPZ, referred to as copper hydrazone), purchased from Sigma Company, mixed with normal rat food at 0.2%, recompressed, and fed for 6-8 weeks;

[0047] 1.3 Experimental animals: C57 male mice, weighing 20-25 g, were purchased from the Experimental Animal Center of Second Military Medical University.

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PUM

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Abstract

The invention relates to the technical field of natural pharmaceutical chemistry and medicine, in particular to application of isoflavonoids, namely tectorigenin and tectoridin, in belamcanda chinensis for treating multiple sclerosis diseases. The scheme adopted by the invention is as follows: a model experiment is conducted that 2% of cuprizone is used to induce demyelination of a mouse, and the experimental result shows that tectorigenin and tectoridin can significantly improve the pathological alteration and ultrastructural changes of demyelination at the callosum part of the mouse in the cuprizone-induced demyelination model; both of tectorigenin and tectoridin can significantly reverse the performance of a decreased myelin-associated protein expression level of the demyelinated mouse induced by cuprizone; both of tectorigenin and tectoridin can significantly alleviate the depression-like behaviors and the spatial learning and memory impairments of the mouse in the demyelination model, and show a remarkable protective function. Therefore, the two isoflavonoids namely tectorigenin and tectoridin can be used to prepare medicine for treating multiple sclerosis related diseases.

Description

technical field [0001] The invention relates to the technical fields of natural medicine chemistry and medicine, in particular to the application of isoflavone compounds in the preparation of medicines for treating multiple sclerosis. Background technique [0002] Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system. It is a disease mainly caused by white matter damage of the brain and spinal cord caused by the joint participation of cellular immunity and humoral immunity. Pathological manifestations include inflammatory response, demyelination, and glial scar formation. The decompensation of demyelination and its repair is one of the pathological basis of CNS functional injury. The course of MS is repeated, and there is still a lack of completely effective treatment measures for MS. Multiple sclerosis can cause depression and impaired learning and memory (see literature: Franco-Pons N, Torrente M, Colomina MT, Vilella E, Behaviora...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/352A61K31/7048A61P25/00A61P25/24A61P25/28
CPCA61K31/352A61K31/7048
Inventor 倪鑫陈海生张琰敏金丽郑幽金永生
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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