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Vilazodone dropping pill and preparation method thereof

A vilazodone dripping pill and vilazodone technology, which is applied in pill delivery, pharmaceutical formulations, medical preparations containing active ingredients, etc., can solve the problems of slow onset of action, heavy taste, and large dosage. Achieve the effects of easier absorption, high drug stability, and uniform drug dispersion

Inactive Publication Date: 2015-04-22
TIANJIN KANGRUI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Most of the existing vilazodone drugs are tablets, which have the disadvantages of large dosage, heavy taste, difficult to swallow, slow onset of action, etc. Therefore, it is the need of current clinical treatment to seek new types of preparations for this type of drugs. The process suitable for the new drug dosage form has also become an important issue of current research

Method used

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Examples

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preparation example Construction

[0021] The invention provides a vilazodone dropping pill and a preparation method thereof. In the method, vilazodone is used as the main raw material, and polyethylene glycol and other substrates are added in a certain proportion, and prepared through specific processes and equipment. made. details as follows:

[0022] (1) Prescription: vilazodone + matrix

[0023] Base: Contains polyethylene glycol (1500, 2000, 4000, 6000, 8000, 10000, 20000), polyoxyl 40 stearate, beta cyclodextrin, poloxamer, sodium carboxymethyl starch, One or more components of stearic acid, sodium stearate, glycerin gelatin, glyceryl monostearate, shellac, polyoxyethylene monostearate, polyether.

[0024] The weight ratio of vilazodone to matrix is ​​1:(1-60).

[0025] (2) Preparation process: the specific implementation steps are as follows:

[0026] In the first step, vilazodone is mixed with the matrix according to a certain ratio.

[0027] The second step is to use water bath, oil bath or other ...

Embodiment 1

[0041] Prescription: Vilazodone 0.5g; PEG4000 5g;

[0042] PEG8000 25g; 1000 capsules in total.

[0043] Preparation method: After mixing vilazodone, PEG4000, and PEG8000 evenly, heat in a water bath to make it melt completely, pour the molten liquid into the material funnel of the dripping pill making machine, keep it warm at 80°C, select the drip nozzle, and drop it into the In simethicone oil at -5°C, after molding, filter, separate, and wipe clean to obtain.

Embodiment 2

[0045] Prescription: Vilazodone 1g; PEG1500 5g;

[0046] PEG6000 25g; 1000 capsules in total.

[0047] Preparation method: Mix vilazodone, PEG1500, and PEG6000 evenly, heat in a water bath to melt completely, pour the molten liquid into the material funnel of the dripping pill making machine, keep it warm at 80°C, select the drip nozzle, and drop it into the In simethicone oil at -5°C, after molding, filter, separate, and wipe clean to obtain.

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PUM

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Abstract

The invention discloses a vilazodone dropping pill for treating adult moderate and major depressive disorders and a preparation method of the vilazodone dropping pill. The preparation method comprises the steps of with vilazodone as a raw material, adding a matrix according to a prescription, and uniformly mixing to obtain a mixed material; heating the mixed material to be molten, and uniformly stirring to obtain a mixture; placing the mixture into a special pill dropping machine; and dropping pills into a condensing agent at a proper speed to condense to form the vilazodone dropping pill. The vilazodone dropping pill is high in bioavailability, capable of rapidly releasing drugs, high in effect taking speed and drug stability and convenient to take; in addition, the consumption of auxiliary materials is reduced, the production process is simple, the preparation method is easy to operate, the weight difference is small, and the production cost is reduced; and no dust is generated, and labor protection can be favorably realized.

Description

technical field [0001] The invention relates to a pharmaceutical preparation and a preparation method thereof, specifically a vilazodone dropping pill and a preparation method thereof. Background technique [0002] Vilazodone, developed by Trovis Pharmaceuticals LLC of the United States, is the first indolealkylamine drug for the treatment of severe depression in adults, and it is a selective serotonin reuptake inhibitor and 5-HT1A receptor partial agonist double effect. In January 2011, the U.S. Food and Drug Administration (FDA) approved vilazodone tablets for the treatment of major depressive disorder (MDD) in adults. [0003] Vilazodone (vilazodone) is a new type of antidepressant. Vilazodone binds to serotonin reuptake site with high affinity (Ki=0.1nM), but binds to norepinephrine (Ki=56nM) or dopamine (Ki=37nM) The reuptake site does not have high affinity. Vilazodone selectively inhibits serotonin reuptake (IC50=1.6nM). Vilazodone also binds to the 5-HT1A recepto...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/496A61P25/24
Inventor 黄四周李明亮王琦
Owner TIANJIN KANGRUI PHARMA
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