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Method for preparing absorbable suture

A technology of sutures and collagen fibers, applied in the field of sutures, can solve the problems of suture quality influence, material hydrolysis deterioration, mechanical strength decline, etc., to achieve the effects of accelerating wound healing, avoiding infection, and stabilizing the absorption period

Active Publication Date: 2015-04-08
SHANDONG BODA MEDICAL PROD CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, chemical line raw materials are less and are controlled by foreign companies, so it is extremely difficult to obtain, and the cost increases a lot
In addition, if the moisture content of the chemical thread is too high, the material will be hydrolyzed and deteriorated, the mechanical strength will be reduced, and the quality of the suture will be seriously affected.
Therefore, the raw materials of the chemical line rely heavily on imports, the procurement cycle is long, and the storage requirements are high

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] The present invention is used to prepare a kind of absorbable suture, and its preparation method comprises the following steps:

[0022] (1) Separation of protein chorion: select fresh goat casings, wash the inner wall of the casing, and scrape the intestinal chorion, mucous membrane, serosa, etc. in the casing to make them fall off;

[0023] (2) Purification of collagen fibers: clean the above sheep casings with clean water, soak them in 0.9% sodium chloride solution for 30 minutes, take them out and soak them in 30% sodium chloride solution for 10 minutes, then separate and cut them off Fat in collagen fibers, to obtain relatively pure collagen fibers;

[0024] (3) Degreasing and degreasing: Add the above-mentioned purified collagen fibers into a 0.5% sodium hydroxide solution at a temperature of 40 degrees Celsius and soak for 15 minutes. The solution also contains 1% dodecylsulfuric acid by weight Sodium, so that the grease between the collagen fibers is completely...

Embodiment 2

[0032] The present invention is used to prepare a kind of absorbable suture, and its preparation method comprises the following steps:

[0033] (1) Separation of protein chorion: select fresh goat casings, wash the inner wall of the casing, and scrape the intestinal chorion, mucous membrane, serosa, etc. in the casing to make them fall off;

[0034] (2) Purification of collagen fibers: clean the above sheep casings with clean water, soak them in 0.9% sodium chloride solution for 30 minutes, take them out and soak them in 30% sodium chloride solution for 10 minutes, then separate and cut them off Fat in collagen fibers, to obtain relatively pure collagen fibers;

[0035] (3) Degreasing and degreasing: Add the above-mentioned purified collagen fibers into a 2% sodium hydroxide solution at a temperature of 60 degrees Celsius and soak for 10 minutes. The solution also contains 0.5% dodecylbenzene by weight. Sodium sulfonate, so that the grease between the collagen fibers is compl...

Embodiment 3

[0043] The present invention is used to prepare a kind of absorbable suture, and its preparation method comprises the following steps:

[0044] (1) Separation of protein chorion: select fresh goat casings, wash the inner wall of the casing, and scrape the intestinal chorion, mucous membrane, serosa, etc. in the casing to make them fall off;

[0045] (2) Purification of collagen fibers: clean the above sheep casings with clean water, soak them in 0.9% sodium chloride solution for 30 minutes, take them out and soak them in 30% sodium chloride solution for 10 minutes, then separate and cut them off Fat in collagen fibers, to obtain relatively pure collagen fibers;

[0046] (3) Degreasing and degreasing: adding the above-mentioned purified collagen fibers to a 1.5% sodium hydroxide solution at a temperature of 55 degrees Celsius and soaking for 12 minutes, and adding 0.8% sodium stearate by weight fraction in the solution, The grease between the collagen fibers is completely sepa...

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PUM

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Abstract

The invention relates to sutures and in particular relates to a method for preparing an absorbable suture. The method for preparing the absorbable suture disclosed by the invention comprises the following steps: (1) separating protein chorion; (2) purifying collagen fibers; (3) deoiling and degreasing; (4) inactivating viruses; (5) performing chrome tanning; (6) performing crosslinking dehydration; (7) polishing; (8) performing chitosan atomization; and (9) packaging. The absorbable suture prepared by the method disclosed by the invention has the characteristics of high tensile strength, knotting firmness, high biocompatibility and small toxic and side effects, and the suture can be absorbed by the body. The suture is completely absorbed, an absorption reaction is avoided, the suture does not need to be taken out, the tissue compatibility is high, and an adverse reaction in the human body is avoided regardless of the time; and moreover, the surface is smooth, the suture is difficultly infected by germs, and infection can be avoided.

Description

(1) Technical field [0001] The invention relates to a suture, in particular to a preparation method of an absorbable suture. (2) Background technology [0002] Medical sutures belong to the category of medical devices. Sutures are divided into two categories in the same industry: one is non-absorbable sutures: silk threads, polypropylene threads, nylon threads, etc.; the other is absorbable sutures: respectively for chemical and biological lines. At present, PGA chemically absorbable sutures are widely used in my country. However, the chemical line raw materials are less and controlled by foreign companies, so it is extremely difficult to obtain, and the cost increases a lot. In addition, if the moisture content of the chemical thread is too high, the material will be hydrolyzed and deteriorated, the mechanical strength will be reduced, and the quality of the suture will be seriously affected. Therefore, the raw materials of the chemical line rely heavily on imports, the ...

Claims

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Application Information

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IPC IPC(8): A61L17/08
Inventor 张玉福高宏宇张硕黄绍青
Owner SHANDONG BODA MEDICAL PROD CO LTD
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