Application of radix bupleuri in preparation of medicines for preventing and treating ionizing radiation injuries

Abstract

The invention relates to the field of medicines, discloses an application of radix bupleuri in preparation of medicines for preventing and treating ionizing radiation injuries, and discloses an application of a total extract of honewort or bupleurum scorzonerifolium in preparation of medicines for preventing and treating the ionizing radiation injuries. A radix bupleuri extract disclosed by the invention plays a radiation protection role in cellular level and animal living level, and plays a protective role under wide dosage ranges of lethal dosage, sub-lethal dosage and low irradiation dosage; and the radix bupleuri extract is stable in quality, low in cost, and wide in source, and can be applied to preparation of medicines for treatment of related injuries caused by ionizing radiation and disease treatment.

Description

Involved areas The invention relates to the field of medicine, in particular to the application of active ingredients extracted from Bupleurum bupleuri or Bupleurum angustifolia in preparation for prevention and treatment of related injuries and diseases caused by ionizing radiation. Background technique With the vigorous development of the global nuclear industry, nuclear technology has been widely used in various fields such as nuclear power plants, aerospace industry, national defense, and biomedicine. The hidden dangers of nuclear war and nuclear terrorism, the protection and treatment of body damage caused by ionizing radiation (referred to as radiation damage) are receiving more and more attention. On the other hand, the incidence of malignant tumors and the number of patients have been on the rise in recent years. Radiation therapy, as one of the main treatment methods, plays an indispensable role, but high-dose radiation exposure will inevitably lead to normal Acu...

AI Technical Summary

Problems solved by technology

Drugs related to the treatment of radiation damage currently on the market mainly include: sulfur-containing compounds, hormones, cytokines, and Chinese herbal medicines, etc., which have their own inherent defects: for example, sulfur-containing compounds generally have relatively large side effects, and amifostine (also known as amifostine ) as the representative of this type of compound is currently recognized as the compound with the best protective effect, and is the first selective broad-spectrum cytoprotective agent passed by the international regulatory agency, but the half-life is extremely short (7 minutes) and expensive (domestic The medical market price is 400-500 yuan / branch) which limits its application; while the prevention and treatment of hormonal drugs to radiation damage is mainly to bone marrow nucleated cells, hematopoietic stem cells and progenitor cells, and the impact of such drugs on sexual organs and reproductive system It limits its wide use; cytokine drugs such as interleukins and colony-stimulating factor drugs can alleviate and treat the damage to the bone marrow hematopoietic function system caused by radiation, but its radiation protection effect is closely related to the time of administration (used for prevention and In the medical practice of rescue and treatment, such drugs require high levels of medical testing and attention), have obvious inflammatory effects, are expensive, and are difficult to store at room temperature; anti-radiation components of Chinese herbal medicines mainly include phenols, polysaccharides, natural Flavonoids have the characteristics of unclear active ingredients and low toxicity. After years of research, there are no similar drugs on the market or to be listed

But so far, the application of Radix Bupleurum in the preparation of prevention and treatment of ionizing radiation damage treatment and tumor radiotherapy adjuvant drug has not been reported.

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