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A kind of tablet containing manidipine hydrochloride and azilsartan and preparation method thereof

A technology of manidipine hydrochloride and tablets, which is applied in the field of tablets containing manidipine hydrochloride and azilsartan and its preparation, can solve the problems of wide range of prescription composition ratios and poor practicability, and achieve good dissolution Accuracy and stability, simple process and low production cost

Active Publication Date: 2016-09-14
XUCHANG HENGSHENG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, its prescription composition ratio range is wide, and its practicability is not strong.

Method used

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  • A kind of tablet containing manidipine hydrochloride and azilsartan and preparation method thereof
  • A kind of tablet containing manidipine hydrochloride and azilsartan and preparation method thereof
  • A kind of tablet containing manidipine hydrochloride and azilsartan and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Embodiment 1: Preparation of a tablet containing manidipine hydrochloride and azilsartan

[0029] prescription:

[0030]

[0031]

[0032] Preparation:

[0033] In the first step, the manidipine hydrochloride and azilsartan are respectively passed through a 100-mesh sieve, and are ultrafinely pulverized, so that the particle diameters of the manidipine hydrochloride and azilsartan are both D90≤25 μm;

[0034] In the second step, weigh 64g of lactose, 43.4g of starch, 16g of low-substituted hydroxypropyl cellulose and 5g of high-substituted hydroxypropyl cellulose, and mix them evenly;

[0035] The 3rd step, take by weighing manidipine hydrochloride 5g and azilsartan 20g after the superfine powder, join in the above-mentioned mixed material that makes, mix homogeneously;

[0036] The fourth step is to weigh 5 g of high-substituted hydroxypropyl cellulose, dissolve it in 57.5 g of purified water, and obtain an aqueous solution of 8% high-substituted hydroxypropyl ...

Embodiment 2

[0039] Embodiment 2: Preparation of a tablet containing manidipine hydrochloride and azilsartan

[0040] prescription:

[0041]

[0042] Preparation:

[0043] In the first step, the manidipine hydrochloride and azilsartan are respectively passed through a 100-mesh sieve, and are ultrafinely pulverized, so that the particle diameters of the manidipine hydrochloride and azilsartan are both D90≤25 μm;

[0044] In the second step, weigh 64g of lactose, 43.4g of starch, 16g of low-substituted hydroxypropyl cellulose and 5g of high-substituted hydroxypropyl cellulose, and mix them evenly;

[0045] The 3rd step, take by weighing manidipine hydrochloride 10g and azilsartan 20g after the superfine powder, join in the above-mentioned mixed material that makes, mix homogeneously;

[0046] The fourth step is to weigh 5 g of high-substituted hydroxypropyl cellulose, dissolve it in 57.5 g of purified water, and obtain an aqueous solution of 8% high-substituted hydroxypropyl cellulose, ...

Embodiment 3

[0049] Embodiment 3: Preparation of a tablet containing manidipine hydrochloride and azilsartan

[0050] prescription:

[0051]

[0052] Preparation:

[0053]In the first step, the manidipine hydrochloride and azilsartan are respectively passed through a 100-mesh sieve, and are ultrafinely pulverized, so that the particle diameters of the manidipine hydrochloride and azilsartan are both D90≤25 μm;

[0054] In the second step, weigh 64g of lactose, 43.4g of starch, 16g of low-substituted hydroxypropyl cellulose and 5g of high-substituted hydroxypropyl cellulose, and mix them evenly;

[0055] The 3rd step, take by weighing manidipine hydrochloride 5g and azilsartan 40g after the superfine powder, join in the above-mentioned mixed material that makes, mix homogeneously;

[0056] The fourth step is to weigh 5 g of high-substituted hydroxypropyl cellulose, dissolve it in 57.5 g of purified water, and obtain an aqueous solution of 8% high-substituted hydroxypropyl cellulose, an...

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Abstract

The invention discloses a manidipine hydrochloride and azilsartan-containing tablet and a preparation method thereof, the manidipine hydrochloride and azilsartan-containing tablet comprises manidipine hydrochloride, azilsartan, lactose, starch, low substituted hydroxypropyl cellulose, high substituted hydroxypropyl cellulose and magnesium stearate, and is prepared by wet granulation process. The tablet is good in solubility and stability, simple in process, low in production cost, and suitable for large-scale industrial production.

Description

technical field [0001] The invention belongs to the technical field of medicines, in particular to a tablet containing manidipine hydrochloride and azilsartan and a preparation method thereof. Background technique [0002] Hypertension is a syndrome with elevated blood pressure as the main clinical manifestation. It is the most common cardiovascular disease and the most important risk factor leading to liver disease, cerebrovascular disease, kidney disease and death. Since hypertension is a multifactorial disease involving the combined effects of genetic and environmental factors, the renin vasodilator-aldosterone system, sympathetic nervous system, body fluid volume system, and cell particle transport system are involved in its occurrence and development. The efficacy of single antihypertensive drugs is often not good, especially for patients with moderate and severe hypertension, antihypertensive drugs should be combined for treatment. [0003] Currently commonly used ant...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/496A61K9/20A61P9/12A61P3/10A61P9/08A61K31/4245
Inventor 蚩晓娜谷志勇邹刚强吕亚军郭培杨豪杰徐安娜
Owner XUCHANG HENGSHENG PHARMA
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