Sustained-release microsphere preparation of goserelin composition
A technology of slow-release microsphere preparation and goserelin, which is applied in the direction of drug combination, medical preparations containing active ingredients, peptide/protein components, etc., to reduce toxic and side effects, improve immunity, and stabilize long-term effective concentration Effect
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Embodiment 1
[0017] Weigh 36g of goserelin, 48g of thymofasin, appropriate amount of gelatin, glycerin and dissolve in distilled water to obtain the inner water phase; weigh 400g of polyhydroxybutyric acid and dissolve in dichloromethane to obtain the oil phase. Prepare 500ml of polyvinyl alcohol solution with a concentration of 5% and 500ml of polyvinyl alcohol solution with a concentration of 0.5%. First transfer the goserelin and thymofasin solution into the dichloromethane solution dissolved in polyhydroxybutyric acid, place it on an emulsifying disperser at room temperature at a speed of 30,000 rpm for 30 seconds, and then mix the obtained W / O emulsion Transfer to 200ml of polyvinyl alcohol solution with a concentration of 5%, place it on an emulsification disperser at a speed of 5000rpm, and milk for 1 minute to obtain a W / O / W type double emulsion, and transfer it to 500ml of 0.5% polyvinyl alcohol solution , placed on a mechanical stirrer, stirred at a low speed of 500rpm for 2 hour...
Embodiment 2
[0024]Weigh 30 g of goserelin, 50 g of thymopentin, appropriate amount of gelatin, and glycerin and dissolve in distilled water to obtain an inner water phase; weigh 400 g of polyvalerate and dissolve in dichloromethane to obtain an oil phase. Prepare 500ml of polyvinyl alcohol solution with a concentration of 5% and 500ml of polyvinyl alcohol solution with a concentration of 0.5%. First move the goserelin and thymopentin solution into the dichloromethane solution dissolved in polyvaleric acid, place it on an emulsifying disperser at room temperature at a speed of 30,000 rpm for 30 seconds, and then mix the obtained W / O emulsion Transfer to 200ml of polyvinyl alcohol solution with a concentration of 5%, place it on an emulsification disperser at a speed of 5000rpm, and milk for 1 minute to obtain a W / O / W type double emulsion, and transfer it to 500ml of 0.5% polyvinyl alcohol solution , placed on a mechanical stirrer, stirred at a low speed of 500rpm for 2 hours, centrifuged, ...
Embodiment 3
[0031] Weigh 80g of goserelin, 120g of thymopentin, appropriate amount of gelatin, glycerin and dissolve in distilled water to obtain the inner water phase; weigh 400g of polyvalonic acid and dissolve in dichloromethane to obtain the oil phase. Prepare 500ml of polyvinyl alcohol solution with a concentration of 5% and 500ml of polyvinyl alcohol solution with a concentration of 0.5%. First move the goserelin and thymopentin solution into the dichloromethane solution dissolved in polyvaleric acid, place it on an emulsifying disperser at room temperature at a speed of 30,000 rpm for 30 seconds, and then mix the obtained W / O emulsion Transfer to 200ml of polyvinyl alcohol solution with a concentration of 5%, place it on an emulsification disperser at a speed of 5000rpm, and milk for 1 minute to obtain a W / O / W type double emulsion, and transfer it to 500ml of 0.5% polyvinyl alcohol solution , placed on a mechanical stirrer, stirred at a low speed of 500rpm for 2 hours, centrifuged ...
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