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Method for fermenting enramycin

A technology of enramycin and fermentation method, applied in the fermentation field of enramycin, can solve the problems of low enramycin fermentation yield and the like, achieve high practical value and significance, and improve the effect of fermentation yield

Inactive Publication Date: 2015-03-18
HENAN TOPFOND PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] In order to solve the technical problem of the low fermentation yield of enramycin in the prior art, the present invention proposes a method for improving the fermentation yield of enramycin

Method used

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  • Method for fermenting enramycin
  • Method for fermenting enramycin
  • Method for fermenting enramycin

Examples

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Embodiment 1

[0019] Example 1: Aseptically insert the cultivated seed liquid into 60L fermentation medium, inoculum size 6L, culture at 25°C for 180 hours, adjust the pH to 6.5 with ammonia water during the fermentation process; the components contained in the fermentation medium are expressed in mass percent corn flour 7%, maltodextrin 12%, gluten powder 4%, corn steep liquor 1.0%, soybean oil 1%, calcium carbonate 1.0%, ammonia water to adjust pH7.5.

Embodiment 2

[0020] Example 2: Aseptically insert the cultivated seed liquid into 50L fermentation medium, inoculum size 7L, culture at 25°C for 180 hours, adjust the pH to 6.5 with ammonia water during the fermentation process; the components contained in the fermentation medium are expressed in mass percent corn flour 10%, maltodextrin 8%, gluten powder 4%, corn steep liquor 1.5%, soybean oil 2%, calcium carbonate 1.0%, ammonia water to adjust pH7.2.

Embodiment 3

[0021] Example 3: Aseptically insert the cultivated seed solution into 50L of fermentation medium, inoculum size 4L, culture at 28°C for 200 hours, adjust the pH to 6.8 with ammonia water during the fermentation process; the components contained in the fermentation medium are expressed in mass percent corn flour 10%, maltodextrin 12%, gluten powder 6%, corn steep liquor 1.2%, soybean oil 3%, calcium carbonate 0.8%, ammonia water to adjust pH7.0.

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Abstract

The invention relates to a method for fermenting enramycin. According to the method, one or more amino acids, such as arginine, phenylalanine, aspartic acid, threonine and lysine, and salts of the amino acid(s) are added into an enramycin fermentation liquid. The method can be used for greatly increasing the yield of enramycin, and is applicable to industrial production.

Description

technical field [0001] The technical field of microbial fermentation of the present invention, in particular, relates to a fermentation method of enramycin. Background technique [0002] It has been nearly 60 years since antibiotics were first added to animal feed at low concentrations to promote growth. Many traditional antibiotics are limited in use due to drug residue and drug resistance issues. As a new type of peptide antibiotic, enramycin has the advantages of stability, broad spectrum, no residue, and no drug resistance; because of its public safety, it is used as a special antibiotic feed additive. is receiving increasing attention. [0003] Enramycin is obtained from the fermentation of Streptomyces fungicidicus, also known as anlamycin, duramycin, etc. It is composed of 17 amino acid molecules and fatty acid molecules of 13 different types. It is a polypeptide antibiotic synthesized by non-ribosomal peptide synthetase (NRPS) catalyzed by different amino acids as...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12P21/02C12R1/465
Inventor 刘俭国焦龙唐慧慧张翠勤王玉梅孔卫红刘新凯王勤波王鑫鲍金庆张锐张增辉李磊董易凡李翠平
Owner HENAN TOPFOND PHARMA
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