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Application of mixture containing four lactic acid bacteria strains in prevention and/or relieving of alcoholic liver diseases

Alcoholic liver disease, including technology, applied in the direction of medical preparations containing active ingredients, applications, food science, etc., can solve problems such as easy side effects and poor curative effect

Inactive Publication Date: 2015-03-18
HUNGKUANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] However, the above-mentioned treatment methods or drugs still have the problems of poor curative effect and easy side effects in clinical application.

Method used

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  • Application of mixture containing four lactic acid bacteria strains in prevention and/or relieving of alcoholic liver diseases
  • Application of mixture containing four lactic acid bacteria strains in prevention and/or relieving of alcoholic liver diseases
  • Application of mixture containing four lactic acid bacteria strains in prevention and/or relieving of alcoholic liver diseases

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Experimental program
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Effect test

preparation example Construction

[0043] 2. Feed preparation:

[0044] For preparation of normal diet and ethanol-containing diet, refer to C.S.Lieber and L.M.Decarli (1982), Alcoholism-Clinical and Experimental Research., 6:523-531 and C.S.Lieber and L.M. Decarli (1989), Alcohol and Alcoholism., 24:197-211 described in the method, with some modifications. And the formulations of the normal feed and the feed containing alcohol are shown in Table 1 below.

[0045] Table 1. Formulations of normal diet and diet containing alcohol

[0046]

[0047]

[0048] 3. Experimental animals:

Embodiment 1

[0053] Embodiment 1. the mixture that contains 4 strains of lactic acid bacteria strains of the present invention is for the assessment of the alleviating effect of mice with alcoholic liver disease (alcoholic liver disease)

[0054] In this experiment, the applicant used alcohol-containing feed to induce alcoholic liver disease in mice, and measured aspartate aminotransferase (AST) and alanine aminotransferase ( alanine aminotransferase, ALT) activity to examine the liver function of mice, and at the same time analyze the triglyceride (triglyceride, TG) contained in the mouse liver, and carry out histopathological examination (histopathological examination) to the liver, thereby evaluate the present invention Alleviating effect of a mixture containing 4 strains of lactic acid bacteria on alcoholic liver lesions.

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Abstract

The invention discloses an application of a mixture containing lactobacillus acidophilus LASW, enterococcus faecium TM39, lactobacillus fermentum LF33 and lactobacillus plantarum BCRC10069 in prevention and / or relieving of alcoholic liver diseases (ALD). The lactobacillus acidophilus LASW, the enterococcus faecium TM39 and the lactobacillus fermentum LF33 are collected in the China Center for Type Culture Collection (CCTCC) with the collection numbers of CCTCC NO:M204083, CCTCC NO:M2012547 and CCTCC NO:M2012548 respectively.

Description

【Technical field】 [0001] The present invention relates to the prevention and / or Relief of alcoholic liver disease (alcoholic liver disease, ALD), wherein the Lactobacillus acidophilus LASW, Enterococcus faecium TM39 and Lactobacillus fermentum LF33 are deposited in the China Center for Type Culture Collection (CCTCC). 【Background technique】 [0002] Alcoholic liver disease is a type of liver injury caused by alcohol overconsumption, which can be divided into the following three stages according to pathophysiology: [0003] (1) Fatty liver (also known as hepatic steatosis) : liver cells cannot efficiently metabolize triglycerides due to excess fatty acids synthesized by liver cells or transported from the blood to the liver Triglyceride (TG), which in turn causes a large amount of fat [including triglyceride, fatty acid (fatty acid) and cholesterol ester (cholesterol ester)] to accumulate in the liver and cause liver disease; [0004] (2) Alcoholic hepatitis (AH): Long-ter...

Claims

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Application Information

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IPC IPC(8): A61K35/747A61K35/744A61P1/16A23L1/30A23G4/12A23L33/135
CPCA61K35/747A23V2002/00A61K35/744
Inventor 曾浩洋刘倚孝蔡宇哲
Owner HUNGKUANG UNIV
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