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Preparation method of quickly-releasing compounded paracetamol and amantadine hydrochloride tablet

A compound paracetamol tablet and immediate-release technology, which can be applied to medical preparations containing active ingredients, pharmaceutical formulations, amine active ingredients, etc., can solve problems such as limited effects, and achieve good immediate-release effects and great clinical significance. Effect

Inactive Publication Date: 2015-03-18
哈药集团人民同泰医药股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The current methods to solve this problem mainly focus on changing the type, dosage and addition method of disintegrants, but the effect is very limited

Method used

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  • Preparation method of quickly-releasing compounded paracetamol and amantadine hydrochloride tablet
  • Preparation method of quickly-releasing compounded paracetamol and amantadine hydrochloride tablet
  • Preparation method of quickly-releasing compounded paracetamol and amantadine hydrochloride tablet

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0018] 1. Pulverize all the raw and auxiliary materials and pass through a 100-mesh sieve, in which silicon dioxide passes through a 50-mesh sieve;

[0019] 2. Mix 15 parts by weight of caffeine, 2 parts by weight of chlorpheniramine maleate and 10 parts by weight of artificial bezoar. During the mixing process, the materials need to pass through a 50-mesh sieve for 3 times;

[0020] 3. Put 100 parts by weight of acetaminophen, 250 parts by weight of amantadine hydrochloride, pre-mixed materials, 40 parts by weight of silicon dioxide and 20 parts by weight of sodium carboxymethyl starch into a wet mixer, and mix for 5 minutes , then add the binder, mix for 3 minutes, and then granulate.

[0021] 4. Move the granules into the boiling dryer, control the temperature of the material at 30-80°C, ventilate and dry for 20-60 minutes, cool the granules to room temperature, carry out sizing, and then move the granules into the mixing machine, add 3 parts by weight of carboxyl Sodium s...

example 2

[0026] 1. Crush all the raw and auxiliary materials and pass through a 120-mesh sieve, among which calcium phosphate passes through a 80-mesh sieve.

[0027] 2. Mix 15 parts by weight of caffeine, 2 parts by weight of chlorpheniramine maleate and 10 parts by weight of artificial bezoar. During the mixing process, the materials need to pass through an 80-mesh sieve for 3 times;

[0028] 3. Put 100 parts by weight of acetaminophen, 250 parts by weight of amantadine hydrochloride, pre-mixed materials, 40 parts by weight of calcium phosphate and 30 parts by weight of sodium carboxymethyl starch into a wet mixer, and mix for 5 minutes , then add the binder, mix for 3 minutes, and then granulate.

[0029] 4. Move the granules into the boiling dryer, control the temperature of the material at 30-80°C, ventilate and dry for 20-60 minutes, cool the granules to room temperature, carry out sizing, and then move the granules into the mixing machine, add 3 parts by weight of carboxyl Sodi...

example 3

[0035] 1. Pulverize all the raw and auxiliary materials and pass through a 120-mesh sieve, in which silicon dioxide passes through a 80-mesh sieve.

[0036] 2. Mix 15 parts by weight of caffeine, 2 parts by weight of chlorpheniramine maleate and 10 parts by weight of artificial bezoar. During the mixing process, the materials need to pass through a 100-mesh sieve for 3 times;

[0037] 3. Put 100 parts by weight of acetaminophen, 250 parts by weight of amantadine hydrochloride, pre-mixed materials and 50 parts by weight of silicon dioxide and 50 parts by weight of sodium carboxymethyl starch into a wet mixer, and mix for 5 Minutes, then add the binder, mix for 3 minutes, and then granulate.

[0038] 4. Move the granules into the boiling dryer, control the temperature of the material at 70°C, ventilate and dry for 20-60 minutes, cool the granules to room temperature, carry out granulation, and then move the granules into the mixing machine, add 7 parts by weight of carboxymethyl...

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Abstract

The invention provides a preparation method of a quickly-releasing compounded paracetamol and amantadine hydrochloride tablet. The preparation method mainly comprises following steps: pulverization, mixing, granulation, granule drying, granule shaping, totally blending and tablet pressing. In the steps of the pulverization, the mixing and the granulation, a preparation technology of a solid dispersing body is employed, wherein a carrier is an indissolvable hydrophilic material. After pulverizing the raw materials and the auxiliary materials into a certain degree, the raw materials and the auxiliary materials are dispersed with the carrier uniformly to prepare the solid dispersing body, and then the solid dispersing body is subjected to other processes and finally is subjected to the tablet pressing to obtain the tablet, which can achieve a good quickly-releasing effect with a dissolution rate being not less than 82% which is indicated. The invention has significant clinical significance in treatment of cold patients.

Description

technical field [0001] The invention relates to a preparation method of tablet medicine, in particular to a preparation method of quick-acting compound acetaminophen tablets. Background technique [0002] Solid preparations, especially tablets, have many advantages over other dosage forms. These advantages include stable physical and chemical properties of the drug, which can ensure the safety of medication for patients; small size, easy to carry, easy to take, etc., this dosage form is now the most widely used. With the continuous development of the pharmaceutical industry, people pay more and more attention to medication safety, and the demand for developing immediate-release tablets that can compete with risky injection preparations continues to increase. The current methods to solve this problem mainly focus on changing the type, dosage and addition method of disintegrants, but the effect is very limited. [0003] Solid dispersion is a dispersion system in which drugs ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/413A61K9/20A61P11/00A61K31/167A61K31/522A61K31/4402A61K31/13
Inventor 刘占滨刘春凤郑龙生
Owner 哈药集团人民同泰医药股份有限公司
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