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Dicarboxylic amino acid-chromium complex and preparation method thereof

A technology of dicarboxyl amino acid and chromium chelate compound is applied in the preparation of organic compounds, cyanide reaction preparation, food preparation and other directions, which can solve the problems of no biological activity, low absorption rate, harmful effects of inorganic chromium, etc., and achieve good biological The effect of compatibility, low toxicity, and superior performance

Inactive Publication Date: 2015-03-11
WUHU LAIBO BIOLOGICAL PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These products not only bring convenience to people’s chromium supplementation, but also have many problems that cannot be overcome: (1) low absorption rate, only 1-3%; (2) no biological activity, need to be converted into bioactive GTF chromium Chromium has the function of regulating metabolism, but the body of patients with diabetes and coronary heart disease basically does not have this transformation ability; (3) the harmful effect of inorganic chromium
Most of the current amino acid chromium is α-amino acid chromium (III) chelate, and the chelating position is on the α-carboxyl group. There are no reports of chelating compounds with chelating positions on the β-carboxyl and γ-carboxyl groups.

Method used

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  • Dicarboxylic amino acid-chromium complex and preparation method thereof
  • Dicarboxylic amino acid-chromium complex and preparation method thereof
  • Dicarboxylic amino acid-chromium complex and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Embodiment 1 prepares asparagus chromium

[0026] The preparation method is as follows:

[0027] (1) Take 2.5203g (0.03mol) of sodium bicarbonate, add 20ml of distilled water, heat slowly to dissolve, add 3.994g (0.03mol) of aspartic acid (add in several times), stir to completely dissolve aspartic acid in In sodium bicarbonate solution (aspartic acid and sodium bicarbonate react to generate aspartic acid monosodium), obtain aspartic acid monosodium solution;

[0028] (2) Take 3.1672g (0.01mol) of chromium trichloride, add 10.27ml of distilled water, shake to make it completely dissolve, and obtain chromium trichloride solution (dark green);

[0029] (3) Mix the above-mentioned chromium trichloride solution with monosodium aspartate solution, the molar ratio of chromium ion to monosodium aspartate is 1:3, stir and react for 10 hours, the color of the mixed solution is from dark green to dark blue → deep purple, finally get the solution of aspartic acid monosodium chel...

Embodiment 2

[0041] Embodiment 2 prepares chromium glutamate

[0042] The preparation method is as follows:

[0043] (1) Take monosodium glutamate 5.0733g, add distilled water 30ml to dissolve, obtain monosodium glutamate solution;

[0044] (2) Take 1.5836g of chromium trichloride, add 10ml of distilled water, shake to make it dissolve completely, and obtain chromium trichloride solution (dark green);

[0045] (3) above-mentioned chromium trichloride solution is mixed with monosodium glutamate solution, stirring reaction 10h, mixed solution color is by dark green→dark blue→dark purple, finally gets the solution of monosodium glutamate chelated chromium ( called chromium glutamate solution);

[0046] (4) The chromium glutamate solution is placed, and crystallization is formed after the water evaporates, which is chromium glutamate.

[0047] Carry out ultraviolet-visible light spectrum scanning to aspartame chromium, obtain ultraviolet-visible light spectrum scanning atlas, such as Figu...

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Abstract

The invention discloses a dicarboxylic amino acid-chromium complex and a preparation method of the dicarboxylic amino acid-chromium complex. The structural formula of the dicarboxylic amino acid-chromium complex is as shown in formula (1) or formula (2) in the description. The preparation method comprises the following steps: (1) taking sodium bicarbonate, adding water for dissolving, adding aspartic acid or glutamic acid, and stirring for dissolving to obtain a monosodium aspartate solution or a monosodium glutamate solution; (2) taking chromium trichloride, and adding water for dissolving to obtain a chromium trichloride solution; (3) mixing the chromium trichloride solution and the monosodium aspartate solution with a monosodium glutamate solution, reacting, placing, and crystallizing to obtain the dicarboxylic amino acid-chromium complex. The dicarboxylic amino acid-chromium complex disclosed by the invention has preferable performance as compared with alpha-carboxyl chelate complex, can be applied to feed, food and pharmaceutical industry as a supplementary product, and can serve as a raw material for preparing nutriments, health care products or medicines for supplementing chromium.

Description

technical field [0001] The invention relates to a dicarboxylic amino acid-chromium chelate and a preparation method thereof. Background technique [0002] As we all know, trivalent chromium Cr(III) is one of the trace elements necessary for human body and animals to maintain normal glucose metabolism and lipid metabolism. The main biological functions of trivalent Cr(III) include: participating in glucose metabolism and Lipid metabolism, maintain blood cholesterol balance (positive trivalent chromium ions on glucose metabolism is mainly to strengthen insulin function; in insulin-dependent tissues, even if there is only an increase of nano-quantity chromium, insulin function will be significantly improved; chromium intake Insufficient, the body's demand for insulin increases; Chromium deficiency can lead to abnormal glucose tolerance, increased blood insulin, decreased insulin affinity, decreased sensitivity of β cells, decreased insulin receptors, hyperglycemia or hypoglycem...

Claims

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Application Information

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IPC IPC(8): C07C229/76C07C229/24C07C227/18A23L1/305A61K31/198A61P3/02A23L33/175
Inventor 王志军马力于东防
Owner WUHU LAIBO BIOLOGICAL PHARMA
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