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Bone repair promoter

A bone repair and enhancer technology, applied in bone diseases, antibody medical components, anti-hormone immunoglobulin, etc., to achieve the effect of improving prognosis and reducing risk

Inactive Publication Date: 2015-02-25
DAIICHI SANKYO CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

As described above, bone repair-promoting drugs exhibiting sufficient actions and effects in bone repair have not been put into practical use, and it is expected to discover or develop a new drug

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0102] Example 1: Rat Femoral Fracture Model Test

[0103] [method]

[0104] The left femoral shaft of a 6-week-old female SD strain (Crl: CD) IGS rat was operated to prepare a fracture model. Barbituryl anesthetic (Somnopentyl®, Kyoritsu Seiyaku Corporation) was intraperitoneally administered to the animal to anesthetize the animal. Perform isoflurane (Escain, Mylan Inc.) inhalation anesthesia as an aid to anesthesia. Cut the skin on the upper side of the knee joint, and peel between the rectus femoris and lateral femoris muscles to expose the femur. At about 0.5 mm distal to the center of the femoral shaft, a bone cutter (Osada Equipment Co., Ltd.) was used to cut the shaft completely in cross section. Then, insert a 21G injection needle into the bone marrow between the left greater trochanter and femoral neck, and suture the muscle and skin with 2 to 3 sutures. In order to prevent postoperative suppuration, antibiotics penicillin G potassium for injection (Meiji Seika Kaisha...

Embodiment 2

[0118] Example 2: Research on the promotion of fracture healing of CNP derivative A in rat closed femoral fracture model

[0119] [method]

[0120] 10-week-old male Wistar rats (Charles River Laboratories Japan, Inc.) were anesthetized by inhalation of isoflurane (5% by inhalation, 2% maintained) and kept in a supine position. Shave the body surface of the left knee with scissors and disinfect with chlorhexidine. Cut the skin of the left knee on the upper side of the patella about 2 cm. Cut the joint capsule together with the outer edge of the patella about 5 mm, and then dislocate the patella inward from the trochlear groove. Insert the 22G injection needle into the medullary cavity in the center of the trochlear groove and pull it out. The Kirschner wire (MIZUHO Corporation), which was previously cut to 32 mm and has a diameter of 1 mm, was inserted into the hole and completely inserted into the femoral medullary cavity. The joint capsule and the incision of the skin were sut...

Embodiment 3

[0124] Example 3: The effect of CNP derivative A on the expression of cartilage-related marker genes in a rat closed femoral fracture model

[0125] [method]

[0126] According to the method of Example 2, a rat closed fracture model was prepared. For animals in the sham operation group, only the needle was inserted into the femur and no fracture was prepared. The administration solution of CNP derivative A was prepared to obtain a dose equivalent to 0.5 mg / kg / day, and then filled into an osmotic pump (Model 2001, Alzet). The osmotic pump was buried under the skin behind the animal's neck and administered subcutaneously for 1 week. The vehicle was continuously subcutaneously administered to the control group. Seven days after the preparation of the fracture, the animals were subjected to isoflurane inhalation anesthesia, maintained in a supine position to open the abdomen, and then euthanized by bleeding. The left femur was excised and immersed in RNAlater (Life Technologies Cor...

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PUM

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Abstract

The present invention provides a bone repair promoter containing as an active ingredient at least one type of B-type natriuretic peptide receptor agonist.

Description

Technical field [0001] The present invention relates to a bone repair promoter containing a natriuretic peptide receptor NPR-B agonist as an active ingredient, and the agonist is represented by a C-type natriuretic peptide (CNP) or a CNP derivative. Background technique [0002] The skeletal system is composed of bone tissue, cartilage and muscles, which play a role in the movement of various parts of the body. Moreover, part of the central nervous tissue and internal organs are located in the skull and spine, and the skeletal system plays a role in protecting the central nervous tissue and internal organs from physical stress caused by the outside world. In addition, the skeletal system is an important reservoir of calcium and phosphorus, and the inside of the bone acts as a place for the preparation of blood cells. The human skeletal system is formed by about 200 bones, classified into several types according to their shapes and properties. The bones called long bones or tubu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/00A61K38/00A61K39/395A61K47/34A61K47/48A61P19/00
CPCA61K38/2242A61K47/48215A61K47/593A61K47/60A61K47/643A61P19/00A61P19/08A61K39/3955C07K16/26C07K2319/30
Inventor 若林直美山木明杉山真佐子
Owner DAIICHI SANKYO CO LTD
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