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Desvenlafaxine succinate sustained-release tablets and preparation method thereof

A technology for desvenlafaxine succinate and sustained-release tablets, which can be applied to pharmaceutical formulations, medical preparations with non-active ingredients, and medical preparations containing active ingredients, etc. Large and other problems, to achieve stable treatment effect, quick effect, and improve the effect of bioavailability

Inactive Publication Date: 2015-02-18
HARBIN SHENGJI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] At present, there are many drugs for the treatment of major depression on the market, but most of the drugs have relatively large effects and side effects, and cannot completely solve this disease

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] A desvenlafaxine succinate sustained-release tablet and a preparation method thereof, which are made of desvenlafaxine succinate, a sustained-release matrix material, and a lubricant, wherein, in parts by weight, desvenlafaxine succinate 50 parts of lafaxine, 150-240 parts of slow-release matrix material, and 10-100 parts of lubricant.

[0030] According to the optimal parts by weight, 50 parts of desvenlafaxine succinate, 195 parts of slow-release matrix material and 55 parts of lubricant.

[0031] The sustained-release matrix material is hypromellose.

[0032] The hypromellose is one or a mixture of 75hd100cr hypromellose, 75hd4000cr hypromellose, 75hd15000cr hypromellose, 100000cr hypromellose.

[0033] Described lubricant is magnesium stearate, talcum powder, silicon dioxide or a mixture of both.

Embodiment 2

[0035] A desvenlafaxine succinate sustained-release tablet and a preparation method thereof, the specific steps of the preparation method are:

[0036] Step 1, material preparation: crush desvenlafaxine succinate with a pulverizer, pass through a 100-mesh sieve, and set aside;

[0037] Step 2: Total mixing: weigh desvenlafaxine succinate and hypromellose in a three-dimensional mixer according to parts by weight and mix for 30 minutes, then take them out for later use;

[0038] Step 3: Granulation: Put the mixed fine powder of raw and auxiliary materials into the wet granulator, use pure water as the binder, put the binder into the liquid supply tank, turn on the machine, adjust the parameters, and start adding the moistening Wet agent, open the shearing flying knife at the same time, 2-5 minutes, discharge, use a swing granulator, granulate with a 20-mesh nylon screen, dry with a fluidized bed dryer, first dry with cool wind, wait After the skin is completely dry, tur...

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PUM

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Abstract

The invention relates to desvenlafaxine succinate sustained-release tablets. The desvenlafaxine succinate sustained-release tablets are prepared from the raw materials in parts by weight: 50 parts of desvenlafaxine succinate, 150-240 parts of sustained-release framework material and 10-100 parts of lubricant. A preparation method of the desvenlafaxine succinate sustained-release tablets comprises the steps of preparing materials, mixing, granulating, mixing, tabletting and carrying out aluminum-plastic packaging. The desvenlafaxine succinate sustained-release tablets disclosed by the invention can be used for effectively curing major depression and are high in effect taking speed, low in side effect, stable in drug release and good in controllability; compared with the tablets currently on the market, the technical advantages are obvious, the bioavailability is improved, novel sustained-release preparations are adopted, and sustained release means delaying the drug release rate of a drug from a dosage form, lowering the organism entering absorption rate of the drug and thus exerting a more stable treatment effect.

Description

technical field [0001] The invention belongs to the technical field of chemical drug sustained-release preparations, and in particular relates to a desvenlafaxine succinate sustained-release tablet and a preparation method thereof. Background technique [0002] Patients with depression often experience a strong sense of disappointment or even hopelessness. Symptoms of major depressive disorder can affect work, study, sleep, diet and social activities. This depression may occur only once, or it may recur many times. [0003] Who is at risk for major depression? [0004] More than 10% of Americans suffer from major depressive disorder, and 20-25% of people have been affected by major depressive disorder in their lifetime. Many people think that only adults suffer from major depressive disorder. In fact, children and the elderly can also suffer from major depression, but these two groups are often neglected and untreated. [0005] Women are twice as likely as men to develop...

Claims

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Application Information

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IPC IPC(8): A61K9/22A61K31/137A61K47/38A61P25/24A61J3/10
Inventor 马玉国
Owner HARBIN SHENGJI PHARMA
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