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Huperzine A tablet and preparation method thereof

A technology of huperzine A tablets and huperzine A, which is applied in the direction of pharmaceutical formula, medical preparations of non-active ingredients, pill delivery, etc. It can solve the problems of slowness, half an hour to reach, and unstable quality, etc. Achieve the effects of improving dissolution rate, accelerating disintegration speed, improving bioavailability and stability

Inactive Publication Date: 2015-02-18
CISEN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although this invention can significantly increase the solubility of the drug and improve the bioavailability, the release rate of huperzine A is still relatively slow, and it can reach more than 97% after half an hour, and its quality is not stable enough

Method used

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  • Huperzine A tablet and preparation method thereof

Examples

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Comparison scheme
Effect test

Embodiment 1

[0014] Composition: Huperzine A 0.5g, starch 320g, lactose 340g, crospovidone 50g, hypromellose 6g, magnesium stearate 3.5g, made into 10,000 tablets.

[0015] Preparation method: 1) Micronized Huperzine A, and all pass through a 120-mesh sieve; 2) Pass the remaining raw materials through a 100-mesh sieve for use; 3) Combine Huperzine A, starch, lactose, and 20g of crospovidone Mix well, then add the hypromellose solution, the solvent of the hypromellose solution is 100g ethanol and 170g water; 4) After being made into a soft material, it is granulated through a 20-mesh sieve, dried, and the inlet air temperature is controlled. Do not exceed 65°C and the water content of the granules is below 4%, then add magnesium stearate and the remaining crospovidone and mix well, then pass through an 18-mesh sieve to obtain mixed granules; 5) Determine the content of Huperzine A in the mixed granules , Determine the tablet weight according to the content, and place the mixed granules on a ta...

Embodiment 2

[0017] Composition: Huperzine A 0.5g, starch 380g, lactose 280g, crospovidone 50g, povidone K306g, magnesium stearate 3.5g, made into 10,000 tablets.

[0018] Preparation method: 1) Micronized Huperzine A, and all pass through a 120-mesh sieve; 2) Pass the filler, disintegrant, and lubricant through a 100-mesh sieve for use; 3) Put the prescription amount of Huperzine A, filled And 22g of disintegrant are mixed uniformly, and then add a prescription amount of binder solution, the solvent of the binder solution is 115g ethanol and 165g water; 4) After being made into soft material, it is granulated through a 20-mesh sieve and dried. Dry, control the inlet air temperature not to exceed 65°C, and the moisture content of the particles below 4%, then add the prescribed amount of lubricant and the remaining disintegrant, mix well, pass through an 18-mesh sieve to obtain mixed particles; 5) Determine the stone in the mixed particles The content of pyrotaxine A is determined according to...

Embodiment 3

[0020] Composition: Huperzine A 0.5g, starch 420g, lactose 240g, crospovidone 50g, povidone K306g, magnesium stearate 3.5g, and benzidine 0.5g, made into 10,000 tablets.

[0021] Preparation method: 1) Micronized Huperzine A, and all pass through a 120-mesh sieve; 2) Pass the remaining raw materials through a 100-mesh sieve for use; 3) Combine Huperzine A, starch, lactose, and 25g of crospovidone Mix well, then add the povidone K30 solution, the solvent of the povidone K30 solution is 120g ethanol and 150g water; 4) After making the soft material, pass through a 20-mesh sieve to granulate, dry, and control the inlet air temperature to not exceed At 65°C, the moisture of the granules is below 4%, then add magnesium stearate and the remaining crospovidone and benedirach to mix well, then pass through an 18-mesh sieve to obtain mixed granules; 5) Determine Huperzine A in the mixed granules According to the content, the tablet weight is determined, and the mixed granules are placed o...

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Abstract

The invention belongs to the technical field of drug preparation, and particularly relates to a huperzine A tablet and a preparation method thereof. The huperzine A tablet comprises the following components in parts by mass: 0.5 parts of huperzine A, 500-700 parts of a filler, 5-15 parts of an adhesive, 20-50 parts of a disintegrating agent, and 1-5 parts of a lubricant, wherein the average particle size of huperzine A is controlled at 110-120 mu m. Compared with the prior art, by carrying out micronization treatment on raw materials, the particle size of huperzine A is controlled at 110-120 mu m, so that the disintegrating speed of the tablet can be increased, and the dissolution of huperzine A can be improved, thereby improving the bioavailability and stability of the huperzine A tablet.

Description

Technical field [0001] The invention belongs to the technical field of medicine preparation, and specifically relates to a Huperzine A tablet and a preparation method thereof. Background technique [0002] Huperzine A is an alkaloid extracted from the unique Chinese plant Melaleuca. Studies have found that Huperzine A can significantly improve memory, improve memory impairment, increase the efficiency of mental activity, senile memory decline and Alzheimer's disease, and adolescents with learning disabilities and memory enhancement. Huperzine A is a potent reversible inhibitor of cholinesterase. It easily penetrates the blood-brain barrier and has a strong inhibitory effect on acetylcholinesterase in the brain. It significantly increases the level of acetylcholine in the brain and is absorbed from the gastrointestinal tract. Good, high safety index, good stability, and long duration of action. It is suitable for benign memory disorders, cerebrovascular diseases, brain trauma, o...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/4748A61K47/38A61K47/36A61K47/32A61P25/28A61P9/14A61P25/00A61P29/00A61P21/00
Inventor 王静姜瑞玲董江涛王守华
Owner CISEN PHARMA
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