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Method for analyzing basic data of Chinese herbal compound based on PK-PD (Pharmacokinetics-Pharmacodynamics)

A PK-PD, material-based technology, applied in the field of data processing, can solve problems such as data false positives, PK/PD data time asynchronous, large data volume differences, etc.

Active Publication Date: 2015-02-11
XIYUAN HOSPITAL OF CHINA ACAD OF CHINESE MEDICAL SCI
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Problems solved by technology

In addition, in the process of data processing, there will also be problems of large differences in experimental data volumes and time asynchronous PK / PD data, as well as problems of false positives in experimental data.

Method used

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  • Method for analyzing basic data of Chinese herbal compound based on PK-PD (Pharmacokinetics-Pharmacodynamics)
  • Method for analyzing basic data of Chinese herbal compound based on PK-PD (Pharmacokinetics-Pharmacodynamics)
  • Method for analyzing basic data of Chinese herbal compound based on PK-PD (Pharmacokinetics-Pharmacodynamics)

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Embodiment Construction

[0018] The first embodiment:

[0019] According to the first embodiment of the present invention. The method of the present invention aims at the pharmacokinetic PK data, by quantitatively describing and analyzing the relationship between the ingredients and the pharmacodynamics, searching and discovering which ingredients contribute to which PD indicators, and how much their contribution is, and then obtain the multi-index pharmacodynamics Kinetics produces correspondingly changing data. The method of the present invention includes the following steps:

[0020] 1. Calculate the empirical distribution function of the measured data at each time point based on the original PK and PD data obtained in the experiment, so as to perform a robust transformation of the measured data.

[0021] The original PK and PD data obtained in the experiment generally fluctuate greatly over time, extremely unstable, the trend item is not obvious, and the dimensions of the data are different. Therefore...

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Abstract

A method for analyzing the basic data of a Chinese herbal compound based on PK-PD (Pharmacokinetics-Pharmacodynamics) comprises the following steps: 1) conducting steady transformation on original PK and PD data obtained by experiments; 2) drawing a virtual observation sample at random based on the empirical distribution function of the PK or PD data of each time point by a re-sampling method based on the overall observation numerical value of the sample, forming a virtual sample orbit through the virtual observation of multiple time points, and simulating the PK or PD measurement process; 3) calculating the accumulative effect of each time point, respectively calculating the relationships between selected PK indexes and PD indexes, and analyzing differences among different groups; 4), calculating the variation rates of the PD indexes of each virtual sample orbit about each herbal ingredient at each time point, and obtaining the action effect of the PK indexes on the PD indexes through the density evolution process of the variation rates. The relationships between the ingredients and the PD indexes are found through the quantitative analysis of the variation relationships between the PK data and the PD data.

Description

Technical field [0001] The invention relates to the field of data processing, and more specifically, to a PK-PD-based material basis data analysis method of a traditional Chinese medicine compound. Background technique [0002] Traditional Chinese medicine compound is a complex system composed of multiple medicinal flavors. Because of its special therapeutic effect on diseases, the research on the material basis related to the efficacy has always been the interest of scholars around the world. [0003] Among the current discussions on the material basis of traditional Chinese medicine compound prescriptions, the PK-PD joint study is the most consistent method of Chinese medicine theory. [0004] PK, or pharmacokinetics, refers to the use of dynamic principles and mathematical models to quantitatively describe the dynamic changes of blood concentration over time during the absorption, distribution, metabolism and excretion of drugs into the body, and to clarify the body’s response to ...

Claims

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Application Information

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IPC IPC(8): G06F17/30G06F19/00
CPCG16H10/40G16H50/50
Inventor 刘建勋安金兵林力张颖林成仁李欣志李磊
Owner XIYUAN HOSPITAL OF CHINA ACAD OF CHINESE MEDICAL SCI
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