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Soft-capsule wall material formula

A technology of soft capsules and capsule materials, which can be used in capsule delivery, pharmaceutical formulations, and medical preparations of non-active ingredients. It can solve the problems of unstable soft capsules and easy cross-linking reactions of gelatin, and achieve good moisturizing effects. Stable in nature, the effect of promoting gallbladder contraction

Inactive Publication Date: 2015-02-04
ZHEJIANG CHUNBAO CAPSULES
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AI Technical Summary

Problems solved by technology

[0004] The problems of existing soft capsule materials include: (1) colloidal material: gelatin is prone to cross-linking reactions, causing instability of soft capsules. In addition, due to the hydrophilicity of gelatin, it is easy to absorb water and dehydrate, preventing absorption in soft capsules. Capsule deformation and leakage caused by moisture in the liquid medicine, and the filling capacity is unqualified

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0054] First put 40kg of purified water, 22kg of glycerin and 18kg of sorbitol into the sol tank, close the feeding port, stir, and raise the temperature of the mixture to 60°C, and ensure that the temperature of the interlayer water is between 60°C and 80°C during the entire sol process.

[0055] Then add polyvinyl alcohol (PVA) 50kg, sodium alginate 7kg, hypromellose 0.1kg and polyethylene oxide 3kg to the sol tank while stirring, control the input speed to prevent agglomeration, and carry out the sol under vacuum conditions, The dissolution time was 1 hour.

[0056] Then dissolve 0.3 kg of pigment with hot water and put it into the glue solution. The sunscreen agent titanium dioxide is made into a mother liquor and put into the glue solution, and stir evenly.

[0057] Sampling to detect the viscosity and moisture of the glue solution. When the viscosity value is 18000pa.s and the moisture is 36.8%, close the air outlet, lock the feeding port, feed compressed air into the so...

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Abstract

The invention discloses a soft capsule wall material formula including 20-40% by weight of polyvinyl alcohol (PVA), 10-40% by weight of a plasticizer, 40-50% by weight of water and 5-15% by weight of a thickening agent, a pigment is added according to color needed by a soft capsule glue ball. By replacement of main component gelatin of the traditional capsule wall material by the polymer polyvinyl alcohol (PVA), many shortcomings of the gelatin are overcome, safety is high, performance is relatively stable, and the crosslinking phenomenon is not easy to occur. No oxidation crosslinking problem occurs, the soft capsule wall material formula is in no need to add antioxidants; the soft capsule wall material formula is added with sorbitol which has excellent moisturizing effect and can effectively prevent drying and aging of soft capsules, when glycerol and sorbitol as a plasticizer are mixed for use, oxygen reaction and matter transport can be prevented, and by addition of thickener sodium alginate, hydroxypropyl methyl cellulose and poly ethylene oxide to improve the glue liquor viscosity, the prepared soft capsule can be sealed without heating.

Description

【Technical field】 [0001] The invention relates to the technical field of pharmaceutical industry production, in particular to the technical field of soft capsule capsule material formulation. 【Background technique】 [0002] Soft capsules refer to medicinal material extracts, liquid drugs or mixed with appropriate excipients and then sealed in hydrophilic soft capsules by drop method or compression method to make spherical, oval or other shapes of dosage forms. Soft capsules are suitable for unstable medicinal substances, such as light-sensitive, volatile, unstable and easily oxidized chemical components, and also suitable for medicinal substances with unpleasant taste and bad smell. After the soft capsule is taken orally, because the drug is wrapped by the hydrophilic gelatin skin and disintegrates quickly in the digestive tract, the drug is released quickly. [0003] Soft capsules are a common dosage form of nutritional supplements and western medicines. Soft capsules have...

Claims

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Application Information

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IPC IPC(8): A61K9/48A61K47/32A61K47/38A61K47/26
Inventor 潘苏枫
Owner ZHEJIANG CHUNBAO CAPSULES
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