Use of a glucocorticoid composition for the treatment of severe and uncontrolled asthma

一种糖皮质激素、组合物的技术，应用在糖皮质激素组合物治疗重度和不受控哮喘领域，能够解决不良副作用、阻碍患者有效治疗等问题

Inactive Publication Date: 2015-01-28
VECTURA LTD
View PDF10 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, serious adverse side effects occur when such high doses of inhalable corticosteroids are administered, preventing effective treatment of these patients

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0126]This example describes the therapy of the invention using a fluticasone composition and an AKITA device adapted to practice the invention. The study was conducted at the Davos Pulmonary Clinic. More than 100 patients with severe asthma who have been chronically maintained on oral corticosteroids are now treated with once-daily inhaled high-dose fluticasone (2000 microgram fluticasone filler dose) using the AKITA system. Patients are selected based on their need for OCS and based on poor symptom control. All patients had been previously treated with an inhaled corticosteroid / beta agonist combination using a metered dose inhaler and a dry powder inhaler and oral steroids at a mean of 22.9 mg / day prednisolone or equivalent. None of the patients had adequately controlled asthma symptoms and adequate lung function as measured by FEV1.

[0127] The treatment period was approximately 1 to 9 weeks, with an average of 3 weeks, inhaled fluticasone 2000 micrograms once daily in a...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

A method for treatment of severe and uncontrollable asthma by providing means for delivery of high doses of a suitable inhalable corticosteroid directly to the small airways of the lower lungs with substantial decrease in need for simultaneous administration of oral corticosteroids and with a significant reduction in undesirable secondary side effects in an oropharyngeal area. The method utilizes devices allowing individualization of treatment parameters in asthmatic patients having compromised breathing pattern due to severe and uncontrollable asthma.

Description

[0001] This application is a divisional application of a Chinese patent application with an application date of February 3, 2010, an application number of 201080006616X, and an invention title of "Use of Glucocorticoid Composition for Treating Severe and Uncontrolled Asthma". technical field [0002] The present invention relates to the use of the glucocorticoid composition for treating severe and uncontrolled asthma. Background of the invention [0003] The present invention relates to methods, devices and compositions for the treatment of severe and uncontrolled asthma. It provides a means of delivering high doses of suitable inhalable corticosteroids to the small and central airways of the lower lungs without requiring or significantly reducing the need for such simultaneous administration of oral corticosteroids. This approach significantly increases the delivery of aerosolized inhalable corticosteroids to the bronchi, bronchioles and alveoli of the central and lower per...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/72A61K9/12A61K31/573A61K31/56A61K31/58A61P11/06
CPCA61K9/0078A61K31/573A61P11/00A61P11/06A61K9/0053A61K9/12
Inventor B.米林格G.索伊希T.霍夫曼P.克罗内贝格
Owner VECTURA LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap