Cabazitaxel lipid microsphere injection and preparation method thereof
A technology of cabazitaxel and lipid microspheres, which is applied in the field of medicine to achieve high dilution resistance, excellent market prospects, and good dilution resistance
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Embodiment 1
[0056] Preparation of cabazitaxel cholesterol complex
[0057] Place 0.1 g of cabazitaxel and 0.3 g of cholesterol in a round-bottomed flask, slowly add ether to immerse the cholesterol and drugs in the ether, and heat and reflux for 2 hours at 60°C to obtain a clear reaction solution, which is dried under reduced pressure to remove Solvent, namely cabazitaxel cholesterol complex.
Embodiment 2
[0059] Preparation of cabazitaxel cholesterol complex
[0060] Place 0.1 g of cabazitaxel and 0.2 g of cholesterol in a round-bottomed flask, slowly add ethyl acetate to immerse the cholesterol and the drug in the ethyl acetate, and heat and reflux at 50°C for 1 hour to obtain a clear reaction solution. Rotary evaporation is used to evaporate the dry solvent to obtain cabazitaxel cholesterol complex.
Embodiment 3
[0062] Preparation of cabazitaxel cholesterol complex
[0063] Place 0.1g of cabazitaxel and 0.25g of cholesterol in a round-bottomed flask, slowly add chloroform to immerse the cholesterol and the drug in the chloroform, heat and reflux for 1 hour at 60°C to obtain a clear reaction solution, and evaporate the dry solvent , That is, cabazitaxel cholesterol complex.
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