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Quantum dot immunochromatographic strip for synchronously quantifying multiple tumor markers and method of quantum dot immunochromatographic strip

A technology of tumor markers and immunochromatography, applied in the field of quantum dot immunochromatography test strips

Inactive Publication Date: 2015-01-07
CHENGDU LINGYU BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] The invention discloses a QD immunochromatographic test strip and its method for simultaneously quantifying multiple tumor markers, so as to solve the problem of synchronous and rapid quantification of multiple indicators of tumor markers in blood samples

Method used

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  • Quantum dot immunochromatographic strip for synchronously quantifying multiple tumor markers and method of quantum dot immunochromatographic strip
  • Quantum dot immunochromatographic strip for synchronously quantifying multiple tumor markers and method of quantum dot immunochromatographic strip
  • Quantum dot immunochromatographic strip for synchronously quantifying multiple tumor markers and method of quantum dot immunochromatographic strip

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Embodiment

[0045] Example: Quantum dot immunochromatography test strips for simultaneous quantification of multiple tumor markers are used for simultaneous quantitative detection of blood tumor markers AFP and CEA

[0046] 1. Strip structure

[0047] combine figure 1 be explained. figure 1 Among them, the quantum dot immunochromatography test strip for simultaneous quantification of multiple tumor markers includes a sample pad 1, a red blood cell filter membrane 2, a marker pad 3, and an analysis membrane 7 that are sequentially overlapped and fixed on the substrate 8 , Absorbent pad6.

[0048] The marking pad 3 of the test strip is a glass fiber membrane. The analysis membrane 7 is a nitrocellulose membrane, a nylon membrane, or a nitrocellulose / acetate mixed membrane, on which there are a detection zone (ie T zone) 4 and a quality control zone (ie C zone) 5 . Described backing 8 is polyester or plastic plate.

[0049] The marker pad 3 is coated with CdSe / ZnS QD 546 Labeled AFP ...

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Abstract

The invention belongs to the field of in-vitro diagnosis and particularly relates to a quantum dot immunochromatographic strip for synchronously quantifying multiple tumor markers and a method of the quantum dot immunochromatographic strip. The quantum dot immunochromatographic strip is characterized in that a marking pad (3) is coated with a mixture of various tumor marker antibodies marked corresponding to quantum dots with different wavelengths, a belt T (4) of an analyzing membrane (7) is coated with a mixture of various tumor marker antibodies, and a belt C (5) of the analyzing membrane (7) is coated with secondary antibodies; a standard curve of each tested object is stored in an electronic tag manner and the electronic tags are mounted on the immunochromatographic strip. According to the quantum dot immunochromatographic strip, a detection instrument having a signal detection function is utilized for reading standard curve data stored in the electronic tags and synchronously and quantitatively detecting concentrations of the various tumor markers in a to-be-detected sample by combining the corresponding fluorescence intensity of the to-be-detected sample measured by the detection instrument.

Description

technical field [0001] The invention belongs to the field of in vitro diagnosis, and in particular relates to a quantum dot immunochromatographic test strip and a method thereof for synchronously quantifying multiple tumor markers. Background technique [0002] Malignant tumor is one of the diseases with high mortality rate at present. It poses a serious threat to the life and health of patients. Early detection, early diagnosis and early treatment are the most important ways for malignant tumor patients to survive. Determining the presence or content of tumor markers is of great significance and practical value for assisting in the diagnosis of tumors, analyzing the course of disease, guiding treatment, monitoring recurrence or metastasis, and judging prognosis. [0003] At present, the serum detection of tumor markers mainly adopts the serum ELISA method. This method requires a centrifuge to separate the serum first, and medical equipment such as an incubator and a microp...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/574
CPCG01N33/588G01N33/574G01N2800/7028
Inventor 王春英马义才侯飞
Owner CHENGDU LINGYU BIOTECH
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