Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Preparation method for taxus chinensis extractive and application of taxus chinensis extractive

A Taxus chinensis extract and Taxus chinensis technology are applied in the directions of drug combinations, medical raw materials derived from gymnosperm subphylum, metabolic diseases, etc., and can solve the problems such as the need to improve the dissolution rate, so as to accelerate the extraction speed, improve the dissolution rate, reduce the The effect of energy consumption

Active Publication Date: 2014-12-31
无锡紫杉药业股份有限公司
View PDF6 Cites 15 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, the extraction method of yew extract traditionally used in traditional Chinese medicine, the dissolution rate needs to be improved

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Preparation method for taxus chinensis extractive and application of taxus chinensis extractive

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] The preparation method of the yew extract of the present embodiment, comprises the steps:

[0031] (1) Prepare the raw material of yew, dry and crush the branches and leaves of yew, pass through an 80-mesh sieve, and the sieve is the raw material of yew, which is set aside.

[0032] (2) Ultrasonic wall breaking treatment, take the undersieve, that is, 10 kg of yew raw material, put it into an ultrasonic wall breaking extraction tank, add 15 times the weight of the yew raw material soaking agent—water, stir and soak at 50 ° C for 1 hour; Use an ultrasonic generator for ultrasonic wall breaking treatment, the power of the ultrasonic generator is 15-30KW, such as 20KW, the frequency is 20-25KHz, such as 23KHz, and the sound intensity is 2W / cm 2 , ultrasonic treatment for 30min to obtain feed liquid.

[0033] (3) enzymatic hydrolysis, the material liquid is transferred to the reaction vessel—that is, in the stirring extraction tank, and neutral protease accounting for 0.3%...

Embodiment 2

[0039] The preparation method of the yew extract of the present embodiment, comprises the steps:

[0040] (1) Prepare the raw material of yew, dry and crush the branches and leaves of yew, pass through an 80-mesh sieve, and the sieve is the raw material of yew, which is set aside.

[0041] (2) Ultrasonic wall breaking treatment, take the undersieve, that is, 10 kg of yew raw material, put it into an ultrasonic wall breaking extraction tank, add 15 times the weight of the yew raw material soaking agent—water, stir and soak at 50 ° C for 1 hour; Use an ultrasonic generator for ultrasonic wall breaking treatment. The power of the ultrasonic generator is 15-30KW, such as 15KW, the frequency is 20-25KHz, such as 20KHz, and the sound intensity is 2W / cm 2 , ultrasonic treatment for 40min to obtain feed liquid.

[0042] (3) enzymatic hydrolysis, the feed liquid is transferred to the reaction vessel—that is, in the stirring extraction tank, and neutral protease accounting for 0.5% of ...

Embodiment 3

[0048] The preparation method of the yew extract of the present embodiment, comprises the steps:

[0049] (1) Prepare the raw material of yew, dry and crush the branches and leaves of yew, pass through an 80-mesh sieve, and the sieve is the raw material of yew, which is set aside.

[0050] (2) Ultrasonic wall breaking treatment, take the undersieve, that is, 10 kg of yew raw material, put it into an ultrasonic wall breaking extraction tank, add 15 times the weight of the yew raw material soaking agent—water, stir and soak at 50 ° C for 1 hour; Use an ultrasonic generator for ultrasonic wall breaking treatment, the power of the ultrasonic generator is 15-30KW, such as 30KW, the frequency is 20-25KHz, such as 25KHz, and the sound intensity is 3W / cm 2 , ultrasonic treatment for 30min to obtain feed liquid.

[0051] (3) enzymatic hydrolysis, the feed liquid is transferred to the reaction vessel—that is, in the stirring extraction tank, and neutral protease accounting for 0.8% of ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a preparation method of taxus chinensis extractive. The preparation method comprises the following steps: (1) preparing a taxus chinensis raw material; (2) conducting ultrasonic wall-breaking treatment, soaking the taxus chinensis raw material in a soaking agent in a stirring manner to obtain a soak solution, and conducting the ultrasonic wall-breaking treatment on the soak solution to obtain a material liquid; (3) performing enzymolysis: transferring the material liquid to a reaction container, adding neutral protease which is 0.3-1.0% of the taxus chinensis raw material in weight to the reaction container, obtaining a mixed liquor, regulating the pH value of the mixed liquid to 6.8-7.0, conducting enzymolysis to hydrolyze free proteins in glycoprotein and glycan, deactivating enzyme, and obtaining a pulp liquid; (4) conducting reflux extraction on the pulp liquid to obtain an extracting solution, filtering and concentrating the extracting solution to obtain a concentrated solution, and filtering the concentrated solution to obtain a filter liquor; (5) conducting spray drying to obtain the taxus chinensis extractive. The preparation method increases the dissolution rate and accelerates the extraction rate.

Description

technical field [0001] The invention relates to a preparation method of a yew extract, and also relates to the application of the yew extract, which belongs to the field of medicinal plant development. Background technique [0002] Taxus is the general name of Taxus genus Taxus. The medicinal value of yew has been recorded in "Compendium of Materia Medica", and it is mainly used for the treatment of cholera, typhoid and for detoxification. It is recorded in "Modern Dictionary of Traditional Chinese Medicine" and "Materia Medica Tui Chen" that its nature and taste are bitter, flat, and slightly poisonous. Modern Chinese medicine also uses it to treat diabetes, kidney disease and gynecological diseases. More than 400 compounds have been isolated from yew plants, the main components are taxanes and non-taxanes. Taxanes are taxane diterpenoids, and non-taxanes are mainly triterpenes, steroids, homoterpenes, flavonoids, phenylpropanoids, and phenols. In my country's tradition...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K36/13A61P35/00A61P3/10A61P37/04A61P3/06A61P9/12A61P29/00A61P9/10
Inventor 田连忠刘雷葛月兰
Owner 无锡紫杉药业股份有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com