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Composition for skin damage repair

A technology for skin damage and composition, which is applied in the field of external preparation composition, and can solve the problems of affecting appearance, easy loss, weak free radical ability, etc.

Active Publication Date: 2014-12-24
SUZHOU RUIPAIER BIOLOGICAL SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

More than two kinds of patented products have two weak points, one, B 12 The aqueous solution is red, and the curcumin aqueous solution is yellow. During the spraying process, it is easy to stain the patient's clothes and skin, which affects the appearance
Second, the above two aqueous solutions are easily lost when sprayed on the skin surface, and more importantly, B in the above two patents 12 (Mr=1355Da) and curcumin (Mr=368Da), although the molecular weights are also small, they are both larger than the molecular weight of syringaldehyde (182.17Da), that is, the permeability of the former two is lower than that of syringaldehyde, and a small amount of B 12 and curcumin have weak ability to scavenge free radicals in deep tissues, not to mention that their own ability to scavenge superoxide free radicals is lower than that of syringaldehyde, such as B 12 The ability to scavenge superoxide free radicals is only 9% of that of SOD (see the invention patent of medical radiation protection spray, ZL200510116829.9); and the deficiency of curcumin in scavenging superoxide free radicals is that it can effectively scavenge within a certain concentration range Superoxide free radicals, if the concentration exceeds a certain level, the ability to scavenge superoxide free radicals will no longer increase. Chen Hong et al. found in research on tumor cell cycle that 10μM curcumin has only 47.8% inhibition rate on free radicals, such as curcumin As the concentration of curcumin increases, the inhibition rate of free radicals remains unchanged (J.Modern Digestion&intervention1999, Vol.14No.2), that is to say, no matter how much concentration of curcumin is increased, there is always a certain amount of superoxide free radicals that cannot be removed

Method used

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  • Composition for skin damage repair
  • Composition for skin damage repair
  • Composition for skin damage repair

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] 1. Hp-β-CD aqueous solution:

[0029] Dissolve 2.0g of commercially available Hp-β-CD in 250ml of pure water and stir for 30 minutes to form an aqueous solution of Hp-β-CD.

[0030] 2. Syringaldehyde Hp-β-CD aqueous solution:

[0031] Add 0.05 g of commercially available syringaldehyde to 30 ml of absolute ethanol, stir to dissolve, and take another 200 ml of Hp-β-CD aqueous solution, add the syringaldehyde absolute ethanol solution and stir for 30 minutes.

[0032] 3. LNAC Hp-β-CD aqueous solution:

[0033] Dissolve 0.25g of commercially available N-acetyl-L-cysteine ​​(LNAC) in 5ml of pure water, take 45ml of Hp-β-CD aqueous solution, mix the two under stirring, and call it LNAC Hp-β-CD aqueous solution.

[0034] 4. Polymer film-forming fluid:

[0035] Commercially available PVA0.5g, PEG0.25g, D-Vc-Na0.05g were dissolved in 250ml pure water, heated and stirred for 30min.

[0036] 5. A composition for skin damage repair:

[0037] Take 50ml of LNAC Hp-β-CD aqueous so...

Embodiment 2

[0039] 1. Hp-β-CD aqueous solution:

[0040] Dissolve 5.0g of commercially available Hp-β-CD in 250ml of pure water and stir for 30 minutes to become an aqueous solution of Hp-β-CD.

[0041] 2. Syringaldehyde Hp-β-CD aqueous solution:

[0042] Add 0.45 g of commercially available syringaldehyde to 30 ml of absolute ethanol, stir to dissolve, and take another 200 ml of Hp-β-CD aqueous solution, add the syringaldehyde absolute ethanol solution and stir for 30 minutes.

[0043] 3. LNAC Hp-β-CD aqueous solution:

[0044] Dissolve 0.6g of commercially available N-acetyl-L-cysteine ​​(LNAC) in 5ml of pure water, take 45ml of Hp-β-CD aqueous solution, mix the two under stirring, and call it LNAC Hp-β-CD aqueous solution.

[0045] 4. Polymer film-forming fluid:

[0046] Commercially available PVA2.0g, PEG0.6g, D-Vc-Na0.08g were dissolved in 250ml pure water, heated and stirred for 30min.

[0047] 5. A composition for skin damage repair:

[0048] Take 50ml of LNAC Hp-β-CD aqueous ...

Embodiment 3

[0050] 1. Hp-β-CD aqueous solution:

[0051] Dissolve 8.0g of commercially available Hp-β-CD in 250ml of pure water and stir for 30min to become an aqueous solution of Hp-β-CD.

[0052] 2. Syringaldehyde Hp-β-CD aqueous solution:

[0053] Add 1.0 g of commercially available syringaldehyde to 30 ml of absolute ethanol, stir to dissolve, and take another 200 ml of Hp-β-CD aqueous solution, add the syringaldehyde absolute ethanol solution and stir for 30 minutes.

[0054] 3. LNAC Hp-β-CD aqueous solution:

[0055] Dissolve 1.0g of commercially available N-acetyl-L-cysteine ​​(LNAC) in 5ml of pure water, take 45ml of Hp-β-CD aqueous solution, mix the two under stirring, and call it LNAC Hp-β-CD aqueous solution.

[0056] 4. Polymer film-forming fluid:

[0057] Commercially available PVA4.0g, PEG1.0g, D-Vc-Na0.3g were dissolved in 250ml pure water, heated and stirred for 30min.

[0058] 5. A composition for skin damage repair:

[0059] Take 50ml of LNAC Hp-β-CD aqueous solutio...

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PUM

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Abstract

The invention relates to an external preparation composition, and particularly relates to a composition for skin damage repair. The composition for skin damage repair is prepared by mixing hydroxypropyl-beta-cyclodextrin (Hp-beta-CD) included syringaldehyde, N-acetyl-L-cysteine (LNAC), SOD, potassium sorbate for preventing the microbial growth and a water-soluble film forming agent consisting of high-modular compounds. The invention also relates to a preparation method of the composition for skin damage repair and an application of the composition for skin damage repair to the skin damage repair. The composition makes up the shortages of the current clinical burn medicines and is capable of accelerating the healing of the wound surfaces.

Description

technical field [0001] The invention relates to an external preparation composition, in particular to a water-soluble film-forming agent composed of syringaldehyde, LNAC, SOD, potassium sorbate for preventing microbial growth, and polymer compounds to form the composition of the invention. The present invention further relates to the preparation method of the composition for repairing skin damage and its application in repairing skin damage. Background technique [0002] Various physical and chemical factors (such as radiation, burns, mechanical damage, long-term ultraviolet radiation, etc.) can cause skin damage. Radiation can ionize the water molecules in the irradiated skin tissue and generate a large number of toxic free radicals (such as superoxide free radicals, hydrated electrons, hydroxyl free radicals, etc.), which in turn cause radiation damage to the irradiated skin tissue (Edited by Su Liaoyuan and Liu Fenju , Fundamentals of Medical Radiation Biology, 2013, 14 ...

Claims

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Application Information

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IPC IPC(8): A61K38/44A61K9/70A61K47/48A61K47/34A61P17/02A61K31/198A61K31/11
Inventor 李洪岩崔凤梅宁萍周平坤江家贵
Owner SUZHOU RUIPAIER BIOLOGICAL SCI & TECH
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