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Preparation method of aminomethylbenzoic acid injection

A technology of aminomethylbenzoic acid and injection, which is applied in the field of preparation of aminomethylbenzoic acid injection, can solve the problems of bacteria in aminomethylbenzoic acid injection, and achieve the effect of ensuring the sterilization effect

Inactive Publication Date: 2014-12-24
SHANGHAI XINYI JINZHU PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
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AI Technical Summary

Problems solved by technology

Bacteria exist in the existing aminomethylbenzoic acid injection

Method used

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Embodiment Construction

[0014] The preparation method of aminomethylbenzoic acid injection of the present invention comprises the following steps:

[0015] Step 1, add freshly boiled water for injection with a preparation amount of 50% in the concentrated preparation tank, add aminomethylbenzoic acid, and stir to dissolve;

[0016] Step 2: Add medicinal charcoal and stir evenly; use Suzhou sand stick to back filter and decarbonize until it is clear, and then filter it into the dilute preparation tank;

[0017] Step 3, add water for injection to the full amount, stir for 15 minutes to make it uniform; adjust the pH value with concentrated hydrochloric acid;

[0018] Step 4, backfiltering with Suzhou sand stick and 0.33 μm polyethersulfone folded filter;

[0019] Step 5: Sampling for inspection of visible foreign matter, and at the same time taking samples and sending them to the testing center to measure the intermediate content and pH value. After all items are qualified, filter the medicinal liquid...

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Abstract

The invention discloses a preparation method of an aminomethylbenzoic acid injection. The method comprises the following steps: 1, adding 50% of newly boiled injection water to a thick mixing tank, adding aminomethylbenzoic acid, stirring and dissolving; 2, adding medicinal carbon and stirring evenly; 3, adding injection water to full dose, and stirring for 15 minutes; 4, filtering by a Suzhou sand rod and a polyether sulfone folding filter of 0.33 micron; 5 sampling and detecting visible foreign particles; 6 filtering a liquid medicine in a storage tank by a polyether sulfone folding filter of 0.41 micron, sampling and detecting the visible foreign particles to be qualified, and then inputting into a base bottle for encapsulating; 7 introducing nitrogen into the base bottle for encapsulating; and 8 sterilizing at the temperature of 121 DEG C for 15 minutes. According to the preparation method, dual sterile filtration is adopted, and the sterilization effect is ensured.

Description

technical field [0001] The present invention relates to a kind of preparation method, relate in particular to a kind of preparation method of aminomethylbenzoic acid injection. Background technique [0002] Aminomethylbenzoic acid injection is a procoagulant drug. There are various natural antagonists of plasmin (original) in the blood circulation, such as anti-plasmin and so on. Under normal circumstances, the activity of anti-fibrinolytic substances in the blood is many times higher than that of fibrinolytic substances, so fibrinolytic bleeding will not occur. However, these antagonists cannot block the activation of activators (such as urokinase, etc.) that have been adsorbed on the fibrin network to form plasmin. Plasmin is an endopeptidase that can cleave the arginine and lysine peptide chains of fibrin in a neutral environment to form fibrin degradation products and cause blood clots to dissolve and bleed. Bacteria exist in the existing aminomethylbenzoic acid inj...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K31/195
Inventor 田玉莲
Owner SHANGHAI XINYI JINZHU PHARMA
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