Products of manufacture having tantalum coated nanostructures, and methods of making and using them

A technology of nanostructures and products, applied in the fields of medicine, nanotechnology, and cell biology, can solve expensive problems

Inactive Publication Date: 2014-12-10
RGT UNIV OF CALIFORNIA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Tantalum is also much ...

Method used

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  • Products of manufacture having tantalum coated nanostructures, and methods of making and using them
  • Products of manufacture having tantalum coated nanostructures, and methods of making and using them
  • Products of manufacture having tantalum coated nanostructures, and methods of making and using them

Examples

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Embodiment 1

[0222] Example 1: The composition of the present invention can effectively induce bone growth

[0223] The data presented herein demonstrates that compositions of the invention (e.g., comprising biomaterials with Ta or Ta oxide-type nanostructures) and methods of the invention are effective and may enable accelerated bone growth and Can be used in a variety of applications including fast and safe orthopedic implants, dental implants, periodontal implants, cell / organ implants, therapeutics and disease diagnostics. This example also describes the preparation of exemplary compositions of the invention.

[0224] In alternative embodiments, the surface of the substrate biomaterial comprises or consists of Ta or Ta oxide or an alloy containing Ta or Ta oxide. In alternative embodiments, other materials are used in the underlying substrate.

[0225] In alternative embodiments, the article of manufacture (article) of the present invention may be obtained by including tantalum or t...

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Abstract

In alternative embodiments, the invention provides products (articles) of manufacture comprising nanostructures such as nanotubes having a surface comprising tantalum. In alternative embodiments, products of manufacture of the invention include nanostructures, e.g., nanotubes, nanowire, nanopore, and the like comprising a surface layer of tantalum. In alternative embodiments, products or articles of manufacture of the invention are bioimplants, and the tantalum-surface-coated nanostructures of the invention provide increased bioactivity and bone forming ability. In alternative embodiments, products or articles of manufacture of the invention, e.g., bioimplants, comprising the tantalum-surface-coated nanostructures of the invention are used for in vitro, ex vivo and in vivo testing, implants, biomedical devices and therapeutics.

Description

[0001] related application [0002] This application claims the benefit of priority to US Provisional Application No. 61 / 596,143, filed February 07, 2012, under 35 U.S.C. § 119(e). The above application is expressly incorporated herein by reference in its entirety for all purposes. technical field [0003] The present invention relates generally to cell biology, medicine and nanotechnology. In an alternative embodiment, the present invention provides an article of manufacture (article) comprising nanostructures (eg, nanotubes) having a surface comprising tantalum. In alternative embodiments, the articles of manufacture of the present invention include nanostructures, eg, nanotubes, nanowires, nanopores, etc., comprising a tantalum surface layer. In an alternative embodiment, the inventive product or article of manufacture is a biological implant, and the inventive tantalum surface-coated nanostructures provide increased bioactivity and bone forming capacity. In alternative ...

Claims

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Application Information

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IPC IPC(8): A61L27/30A61L27/38A61F2/28B22F1/08B22F1/17
CPCA61L2430/02A61L2430/38A61L27/306A61L2400/12A61L27/047A61L31/088A61L2430/24A61L27/38B22F1/0025A61F2/30767B22F1/025B82Y30/00A61F2002/3084A61L31/022C12M25/00Y10T428/24909Y10T428/25Y10T428/12028Y10T428/26Y10T428/24893Y10T428/31678B22F1/0547B22F1/17B22F1/08
Inventor 陈星皓克里斯廷·弗兰德森
Owner RGT UNIV OF CALIFORNIA
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