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Loxoprofen sodium gel and preparation method thereof

A technology for loxoprofen sodium and gel is applied in the field of loxoprofen sodium gel and its preparation, which can solve the problems of discomfort, inconvenience, redness and swelling of the skin, and achieves quicker onset of effect, convenient use and manufacturing low cost effect

Inactive Publication Date: 2014-12-10
天津市聚星康华医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, loxoprofen sodium products on the domestic market are mainly oral preparations, and the external preparations are only cataplasms imported from Japan. Redness and other defects

Method used

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  • Loxoprofen sodium gel and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] The preparation process is as follows:

[0032] (1) Weigh 2g of loxoprofen sodium, 6g of carbomer 934, 20g of glycerin, 5g of sodium benzoate, and 1g of sodium bisulfite;

[0033] (2) Weigh 600g of purified water, add Carbomer 934 under high-speed stirring, continue to stir until it is completely dispersed in water, add sodium hydroxide to adjust the pH to 4.0 after swelling is complete, and prepare solution a;

[0034] (3) Loxoprofen sodium is crushed with a pulverizer, passed through a 200-mesh sieve, and then loxoprofen sodium, glycerin, sodium benzoate, and sodium bisulfite are dissolved in 50 g of ethanol, and then added to solution a. Supplement purified water to 1000g, fully stir, obtain transparent loxoprofen sodium gel.

[0035] Evaluation: The matrix has good uniformity, fineness, and no granular micelles; it is easy to apply on the back of the hand and has good skin adhesion (apply the forming gel on the back of the hand and shake it vigorously for 10 ti...

Embodiment 2

[0037] The preparation process is as follows:

[0038] (1) Weighing: Loxoprofen Sodium 2g, Carbomer 940 6g, Glycerin 30g, Potassium Sorbate 5g, Sodium Metabisulfite 2g;

[0039] (2) Weigh 600g of purified water, add Carbomer 940 under high-speed stirring, continue to stir until it is completely dispersed in water, add sodium hydroxide to adjust the pH to 4.5 after swelling is complete, and prepare solution a;

[0040] (3) Loxoprofen sodium is crushed with a pulverizer, passed through a 200-mesh sieve, and then loxoprofen sodium, glycerin, potassium sorbate, and sodium metabisulfite are dissolved in 50 g of ethanol, then added to solution a, and added Purified water to 1000g, fully stirred to obtain transparent loxoprofen sodium gel.

[0041] Evaluation: The matrix has good uniformity, fineness, and no granular micelles; it is easy to apply on the back of the hand and has good skin adhesion (apply the forming gel on the back of the hand and shake it vigorously for 10 times...

Embodiment 3

[0043] The preparation process is as follows:

[0044] (1) Weighing: Loxoprofen sodium 2g, Carbomer 941 6g, propylene glycol 30g, ethylparaben 5g, sodium thiosulfate 2g;

[0045](2) Weigh 600g of purified water, add Carbomer 941 under high-speed stirring, continue to stir until it is completely dispersed in water, add triethanolamine to adjust the pH to 4.5 after swelling is complete, and prepare solution a;

[0046] (3) Loxoprofen sodium is crushed with a pulverizer, passed through a 200-mesh sieve, and then loxoprofen sodium, propylene glycol, ethyl paraben, and sodium thiosulfate are dissolved in 30 g of ethanol, and then added to solution a , add purified water to 1000g, fully stir to obtain transparent loxoprofen sodium gel.

[0047] Evaluation: The matrix has good uniformity, fineness, and no granular micelles; it is easy to apply on the back of the hand and has good skin adhesion (apply the forming gel on the back of the hand and shake it vigorously for 10 times wi...

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Abstract

The invention belongs to the technical field of medicines, and relates to loxoprofen sodium gel and a preparation method thereof. The loxoprofen sodium gel is suitable for inflammation diminishing and pain stopping of arthritis deformans, courbature and wounds. Compared with an oral product in the market at present, the loxoprofen sodium gel disclosed by the invention has the characteristics that the preparation technology is simple and feasible, and the loxoprofen sodium gel directly acts on the wound, takes a quick effect and is convenient to use.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and relates to a loxoprofen sodium gel and a preparation method thereof. Background technique [0002] Loxoprofen sodium belongs to phenylpropionic acid non-steroidal anti-inflammatory drugs. It was first successfully developed by Daiichi Sankyo Co., Ltd. in Japan. It was listed in Japan in 1986. It is widely used and has been recorded in the Japanese Pharmacopoeia. Its raw materials and tablets have been imported into our country. Compared with similar clinical drugs, loxoprofen sodium has the following characteristics: stronger (better clinical effect), faster (rapid oral absorption), safer (less side effects). Another feature is that it has a wide range of indications, and it can be widely used clinically for anti-inflammatory and analgesic treatment of rheumatoid arthritis, low back pain, frozen shoulder, neck, shoulder and wrist syndrome, etc. Antipyretic and analgesic for acute...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K31/192A61P29/00
Inventor 赵伟康静李化淋王红霞
Owner 天津市聚星康华医药科技有限公司
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