Endoscopic x-ray luminescence tomography device and method

Abstract

An endoscopic X-ray luminescence tomography device, comprising: an excitation source unit (1), used to excite a probe inside an object under inspection from an external excitation source; a signal acquisition unit (2), used to collect the probe of the object under inspection The X-ray image and the near-infrared light signal image emitted after the probe is excited; the calculation unit (4) is used to preprocess the collected X-ray image and infrared light signal image, and to preprocess the X-ray image Sparse reconstruction is performed to obtain the structural information of the inspected object and the position information of the endoscopic probe in the signal acquisition unit inside the inspected object, and the preprocessed near-infrared light signal image is processed by using the obtained structural information and position information Perform optical three-dimensional reconstruction to obtain the position information and distribution information of the target inside the object under inspection.

Description

technical field [0001] The present invention relates to the technical field of medical imaging, and further relates to an endoscopic X-ray luminescence tomography device and an endoscopic X-ray luminescence tomography method. Background technique [0002] Because it can three-dimensionally reconstruct the spatial position and concentration distribution of fluorescent probes in organisms, fluorescence diffusion tomography (FDOT) has become a molecular imaging technology with great application potential. Among its potential applications, FDOT has been widely used in imaging small animals or superficial organs, such as brain and mammary gland. In this case, the fluorescent signal can penetrate the imaged object and be picked up by an external detection component. However, for the internal organs of the subject deeply buried in such as a large animal body or human body, due to the severe attenuation of fluorescence in the body, the FDOT technique cannot provide accurate images,...

AI Technical Summary

Problems solved by technology

However, due to the limitation of the penetration depth of the emitted near-infrared light, XLCT technology can still only be used for imaging small animal bodies and superficial organs.

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