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A method for preparing magnolol and honokiol from magnolol leaves

A technology of honokiol and magnolol, applied in the direction of chemical instruments and methods, preparation of organic compounds, non-central analgesics, etc., can solve the problems that are not conducive to the implementation of industrialization, not conducive to the protection of laborers, and increase operational risks In order to achieve the effects of low cost, large sample loading and short production cycle

Active Publication Date: 2015-10-14
昆明梓橦宫全新生物制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These factors increase the risk of operation, which is not conducive to the protection of laborers, nor to the implementation of industrialization
The cost of petroleum ether is higher

Method used

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  • A method for preparing magnolol and honokiol from magnolol leaves
  • A method for preparing magnolol and honokiol from magnolol leaves
  • A method for preparing magnolol and honokiol from magnolol leaves

Examples

Experimental program
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Effect test

Embodiment 1

[0038] 1. Take 96g of Magnolia officinalis leaves and grind them to a particle size of 40 mesh;

[0039]2. Magnolia officinalis leaf powder is reflux extracted three times with ammonia water to adjust the pH value of 10 95% ethanol solution, the extraction temperature is 60 ° C, wherein the first 500ml solution is reflux extracted for 2 hours and then filtered, and the filter residue is reflux extracted for the second time with 500ml solution for 1 hour After filtering, the filter residue was refluxed for the third time with 500ml of solution and filtered for 0.5 hours, and the three extracts were combined; the pH value was adjusted to 6 with hydrochloric acid, and the solvent was recovered to obtain a crude extract (28.8g);

[0040] 3. Dissolve the crude extract in 300ml of water, extract 3 times with dichloromethane, 300ml each time, combine the dichloromethane solution, and evaporate to dryness to obtain extract (14.2g);

[0041] 4. Take 500g of small-pore separation resin ...

Embodiment 2

[0045] 1. Take 95g of Magnolia officinalis leaves and crush until the particle size is 40 mesh;

[0046] 2. Magnolia officinalis leaf powder is reflux extracted three times with ammonia water to adjust the pH value of 95% ethanol solution, the extraction temperature is 60 ° C, wherein the first 500ml solution is reflux extracted for 2 hours and then filtered, and the filter residue is reflux extracted for the second time with 500ml solution for 1 hour After filtering, the filter residue was refluxed for the third time with 500ml solution and filtered for 0.5 hours, and the three extracts were combined; the pH value was adjusted to 6 with hydrochloric acid, and the solvent was recovered to obtain a crude extract (28.2g);

[0047] 3. Dissolve the crude extract in 300ml of water, filter, dissolve the residue in 100ml of acetone, add 400ml of water to form a suspension, use 100g of alumina to absorb and enrich, collect the effluent, evaporate to dryness, and obtain an extract (13.3...

Embodiment 3

[0052] 1. Take 98g Magnolia officinalis leaves and grind them to a particle size of 40 mesh;

[0053] 2. Magnolia officinalis leaf powder is reflux extracted twice with ammonia water to adjust the pH value of 9 60% methanol solution, the extraction temperature is 70 ° C, wherein the first 500ml solution is reflux extracted for 3 hours and then filtered, and the filter residue is reflux extracted for the second time with 500ml solution 2 Filtrate after 1 hour, combine two extracts; Regulate pH value 7 with hydrochloric acid, reclaim solvent, obtain crude extract (29.4g);

[0054] 3. Dissolve the crude extract in 300ml of water, extract twice with dichloromethane, 300ml each time, combine the dichloromethane solution, evaporate to dryness, and obtain extract (15.2g);

[0055] 4. Take 500g of small pore size separation resin Chroma-R204 and pressurize the column, equilibrate the column with methanol aqueous solution with a concentration of 35% by volume, and then slowly add the s...

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Abstract

The invention relates to a method for preparing magnolol and honokiol from Mangnolia officinalis leaves, belonging to the field of modernization of traditional Chinese medicines. The method comprises the following steps: extracting with an organic solvent, separating and preparing with a small-pore-size resin, crystallizing with the organic solvent and the like to prepare the high-purity magnolol and honokiol components from the Mangnolia officinalis leaves. Compared with the existing process, the method has the advantages of simple technique, low cost of the crude extraction solvent, low cost of column chromatography, high separation precision and recyclability of the filler, low cost of the chromatography solvent, low environmental pollution, high purity of the magnolol and honokiol, and the like, and is suitable for industrial preparation.

Description

technical field [0001] The invention relates to a method for preparing magnolol (Magnolol) and honokiol (Honokiol) from magnolia leaves, belonging to the field of traditional Chinese medicine modernization. Background technique [0002] Magnolol and honokiol are isomers, and they are the antibacterial active components of Magnolia officinalis commonly used in traditional Chinese medicine, and they are also the main index components of the quality control of Magnolia officinalis. It has been reported in the literature that in addition to antibacterial effects, the two also have anti-inflammatory, anti-anxiety, anti-depressant, anti-tumor, anti-aging and cardioprotective effects; in addition, there are obvious and long-lasting central muscle relaxation and central nervous inhibition effects; recently Pharmacodynamic studies have confirmed that magnolol and honokiol also exhibit hypoglycemic activity. [0003] Magnolia officinalis is a commonly used traditional Chinese medicin...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C39/21C07C37/68A61K31/05A61P29/00A61P25/22A61P25/24A61P35/00A61P39/00A61P3/10A61P9/10A61P31/04
CPCA61K31/05C07C37/004C07C39/21
Inventor 杨竹雅谭文红马晓霞钱子刚卫莹芳杨树德张宝洪
Owner 昆明梓橦宫全新生物制药有限公司
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